Regulatory T Cell Metabolism in Atherosclerosis

Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall...

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Veröffentlicht in:Metabolites Jg. 10; H. 7; S. 279
Hauptverfasser: Baardman, Jeroen, Lutgens, Esther
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 08.07.2020
MDPI
Schlagworte:
Acute coronary syndromes
Antigens
Apolipoproteins
Apoptosis
Arteriosclerosis
Atherosclerosis
Autoimmunity
Cardiovascular disease
Cardiovascular diseases
Cell growth
Cholesterol
Collagen
Cytokines
Foxp3
Homeostasis
immunometabolism
Immunoregulation
Inflammatory diseases
Lymphocytes
Lymphocytes T
Metabolism
Proteins
Review
T cells
Transcription factors
Tregs
ISSN:2218-1989, 2218-1989
Online-Zugang:Volltext
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Zusammenfassung:Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall and the leading cause of cardiovascular disease. Therefore, therapeutic strategies to improve Treg number or function could be beneficial to preventing atherosclerotic disease development. A growing body of evidence shows that intracellular metabolism of Tregs is a key regulator of their proliferation, suppressive function, and stability. Here we evaluate the role of Tregs in atherosclerosis, their metabolic regulation, and the links between their metabolism and atherosclerosis.
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ISSN:2218-1989
2218-1989
DOI:10.3390/metabo10070279