Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child

A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory investigations revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid. Genomic analysis strongly sugge...

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Vydáno v:Clinical infectious diseases Ročník 64; číslo 4; s. 513
Hlavní autoři: Sissoko, Daouda, Keïta, Mory, Diallo, Boubacar, Aliabadi, Negar, Fitter, David L, Dahl, Benjamin A, Akoi Bore, Joseph, Raymond Koundouno, Fara, Singethan, Katrin, Meisel, Sarah, Enkirch, Theresa, Mazzarelli, Antonio, Amburgey, Victoria, Faye, Ousmane, Alpha Sall, Amadou, Magassouba, N'Faly, Carroll, Miles W, Anglaret, Xavier, Malvy, Denis, Formenty, Pierre, Bruce Aylward, Raymond, Keïta, Sakoba, Harouna Djingarey, Mamoudou, Loman, Nicholas J, Günther, Stephan, Duraffour, Sophie
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 15.02.2017
Témata:
Adult
Cluster Analysis
Ebolavirus - isolation & purification
Female
Hemorrhagic Fever, Ebola - transmission
Humans
Infant
Infectious Disease Transmission, Vertical
Male
Milk, Human - virology
Phylogeny
RNA, Viral - genetics
RNA, Viral - isolation & purification
Semen - virology
Sequence Analysis, DNA
Sequence Homology
Young Adult
Ebola virus
real-time sequencing
breast milk
asymptomatic carriage
mother-to-child transmission
ISSN:1537-6591, 1537-6591
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Abstract A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory investigations revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid. Genomic analysis strongly suggests EBOV transmission to the child through breastfeeding.
AbstractList A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory investigations revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid. Genomic analysis strongly suggests EBOV transmission to the child through breastfeeding.A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory investigations revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid. Genomic analysis strongly suggests EBOV transmission to the child through breastfeeding.
A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory investigations revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid. Genomic analysis strongly suggests EBOV transmission to the child through breastfeeding.
Author Keïta, Mory
Anglaret, Xavier
Singethan, Katrin
Magassouba, N'Faly
Enkirch, Theresa
Aliabadi, Negar
Amburgey, Victoria
Duraffour, Sophie
Alpha Sall, Amadou
Raymond Koundouno, Fara
Günther, Stephan
Bruce Aylward, Raymond
Loman, Nicholas J
Mazzarelli, Antonio
Faye, Ousmane
Diallo, Boubacar
Harouna Djingarey, Mamoudou
Sissoko, Daouda
Akoi Bore, Joseph
Malvy, Denis
Keïta, Sakoba
Carroll, Miles W
Fitter, David L
Dahl, Benjamin A
Meisel, Sarah
Formenty, Pierre
Author_xml – sequence: 1
  givenname: Daouda
  surname: Sissoko
  fullname: Sissoko, Daouda
  organization: Bordeaux University Hospital, Bordeaux, France
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  givenname: Mory
  surname: Keïta
  fullname: Keïta, Mory
  organization: World Health Organization, Conakry, Guinea
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  givenname: Boubacar
  surname: Diallo
  fullname: Diallo, Boubacar
  organization: World Health Organization, Conakry, Guinea
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  givenname: Negar
  surname: Aliabadi
  fullname: Aliabadi, Negar
  organization: Centers for Disease Control and Prevention, Atlanta, Georgia
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  givenname: David L
  surname: Fitter
  fullname: Fitter, David L
  organization: Centers for Disease Control and Prevention, Atlanta, Georgia
– sequence: 6
  givenname: Benjamin A
  surname: Dahl
  fullname: Dahl, Benjamin A
  organization: Centers for Disease Control and Prevention, Atlanta, Georgia
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  organization: Ministry of Health, Conakry, Guinea
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  surname: Raymond Koundouno
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  organization: Ministry of Health, Conakry, Guinea
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  givenname: Katrin
  surname: Singethan
  fullname: Singethan, Katrin
  organization: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich
– sequence: 10
  givenname: Sarah
  surname: Meisel
  fullname: Meisel, Sarah
  organization: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
– sequence: 11
  givenname: Theresa
  surname: Enkirch
  fullname: Enkirch, Theresa
  organization: Paul-Ehrlich-Institut, Division of Veterinary Medicine, Langen, Germany
– sequence: 12
  givenname: Antonio
  surname: Mazzarelli
  fullname: Mazzarelli, Antonio
  organization: National Institute for Infectious Diseases "L. Spallanzani", Rome, Italy
– sequence: 13
  givenname: Victoria
  surname: Amburgey
  fullname: Amburgey, Victoria
  organization: Ratoma Ebola Diagnostic Center, Conakry, Guinea
– sequence: 14
  givenname: Ousmane
  surname: Faye
  fullname: Faye, Ousmane
  organization: Institut Pasteur, Dakar, Senegal
– sequence: 15
  givenname: Amadou
  surname: Alpha Sall
  fullname: Alpha Sall, Amadou
  organization: Institut Pasteur, Dakar, Senegal
– sequence: 16
  givenname: N'Faly
  surname: Magassouba
  fullname: Magassouba, N'Faly
  organization: Université Gamal Abdel Nasser de Conakry, Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, Guinea
– sequence: 17
  givenname: Miles W
  surname: Carroll
  fullname: Carroll, Miles W
  organization: University of Southampton, South General Hospital, Southampton, United Kingdom
– sequence: 18
  givenname: Xavier
  surname: Anglaret
  fullname: Anglaret, Xavier
  organization: PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire
– sequence: 19
  givenname: Denis
  surname: Malvy
  fullname: Malvy, Denis
  organization: Bordeaux University Hospital, Bordeaux, France
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  givenname: Pierre
  surname: Formenty
  fullname: Formenty, Pierre
  organization: World Health Organization, Geneva, Switzerland
– sequence: 21
  givenname: Raymond
  surname: Bruce Aylward
  fullname: Bruce Aylward, Raymond
  organization: World Health Organization, Geneva, Switzerland
– sequence: 22
  givenname: Sakoba
  surname: Keïta
  fullname: Keïta, Sakoba
  organization: Ministry of Health, Conakry, Guinea
– sequence: 23
  givenname: Mamoudou
  surname: Harouna Djingarey
  fullname: Harouna Djingarey, Mamoudou
  organization: World Health Organization, Conakry, Guinea
– sequence: 24
  givenname: Nicholas J
  surname: Loman
  fullname: Loman, Nicholas J
  organization: Institute of Microbiology and Infection, University of Birmingham, United Kingdom
– sequence: 25
  givenname: Stephan
  surname: Günther
  fullname: Günther, Stephan
  organization: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
– sequence: 26
  givenname: Sophie
  surname: Duraffour
  fullname: Duraffour, Sophie
  organization: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
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Keywords Ebola virus
real-time sequencing
breast milk
asymptomatic carriage
mother-to-child transmission
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Snippet A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory...
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SubjectTerms Adult
Cluster Analysis
Ebolavirus - isolation & purification
Female
Hemorrhagic Fever, Ebola - transmission
Humans
Infant
Infectious Disease Transmission, Vertical
Male
Milk, Human - virology
Phylogeny
RNA, Viral - genetics
RNA, Viral - isolation & purification
Semen - virology
Sequence Analysis, DNA
Sequence Homology
Young Adult
Title Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child
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