Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child

A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory investigations revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid. Genomic analysis strongly sugge...

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Vydáno v:Clinical infectious diseases Ročník 64; číslo 4; s. 513
Hlavní autoři: Sissoko, Daouda, Keïta, Mory, Diallo, Boubacar, Aliabadi, Negar, Fitter, David L, Dahl, Benjamin A, Akoi Bore, Joseph, Raymond Koundouno, Fara, Singethan, Katrin, Meisel, Sarah, Enkirch, Theresa, Mazzarelli, Antonio, Amburgey, Victoria, Faye, Ousmane, Alpha Sall, Amadou, Magassouba, N'Faly, Carroll, Miles W, Anglaret, Xavier, Malvy, Denis, Formenty, Pierre, Bruce Aylward, Raymond, Keïta, Sakoba, Harouna Djingarey, Mamoudou, Loman, Nicholas J, Günther, Stephan, Duraffour, Sophie
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 15.02.2017
Témata:
Adult
Cluster Analysis
Ebolavirus - isolation & purification
Female
Hemorrhagic Fever, Ebola - transmission
Humans
Infant
Infectious Disease Transmission, Vertical
Male
Milk, Human - virology
Phylogeny
RNA, Viral - genetics
RNA, Viral - isolation & purification
Semen - virology
Sequence Analysis, DNA
Sequence Homology
Young Adult
Ebola virus
real-time sequencing
breast milk
asymptomatic carriage
mother-to-child transmission
ISSN:1537-6591, 1537-6591
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Shrnutí:A 9-month-old infant died from Ebola virus (EBOV) disease with unknown epidemiological link. While her parents did not report previous illness, laboratory investigations revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid. Genomic analysis strongly suggests EBOV transmission to the child through breastfeeding.
Bibliografie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1537-6591
1537-6591
DOI:10.1093/cid/ciw793