Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

Iron is essential for many types of biological processes. However, excessive iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron-dependent regulated form of necrosis, was recently discovered, iron and iron-catalysed oxidative stress have attracted much interest b...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1863; no. 9; pp. 1398 - 1409
Main Authors:	Nakamura, Toshitaka, Naguro, Isao, Ichijo, Hidenori
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2019
Subjects:	Apoptosis Apoptosis signal-regulating kinase 1 (ASK1) Cancer catalytic activity Cell Death Cellular Senescence cytotoxicity Ferroptosis Homeostasis human diseases Humans Iron Iron - metabolism lipids mitogen-activated protein kinase necrosis neoplasms organelles Oxidative Stress reactive oxygen species Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Senescence Signal Transduction therapeutics Ferroptosis Senescence Iron Apoptosis signal-regulating kinase 1 (ASK1) Reactive oxygen species (ROS) Cancer
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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