Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Anemia associated with PNH is caused by hemolysis. The C5 inhibitor eculizumab blocks intravascular hemolysis, but anemia often persists owing to extravascular hemolysis. Pegcetacoplan, an inhibitor of C3, prevents extravascular hemolysis. After 16 weeks of treatment, hemoglobin increased nearly 4 g...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 384; no. 11; pp. 1028 - 1037
Main Authors:	Hillmen, Peter, Szer, Jeff, Weitz, Ilene, Röth, Alexander, Höchsmann, Britta, Panse, Jens, Usuki, Kensuke, Griffin, Morag, Kiladjian, Jean-Jacques, de Castro, Carlos, Nishimori, Hisakazu, Tan, Lisa, Hamdani, Mohamed, Deschatelets, Pascal, Francois, Cedric, Grossi, Federico, Ajayi, Temitayo, Risitano, Antonio, de la Tour, Régis Peffault
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 18.03.2021
Subjects:	Adult Adverse events Aged Aged, 80 and over Anemia Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Blood diseases Chronic illnesses Complement C3 - antagonists & inhibitors Complement C5 - antagonists & inhibitors Complement component C3 Complement component C5 Complement Inactivating Agents - adverse effects Complement Inactivating Agents - therapeutic use Complement system Diarrhea Diarrhea - chemically induced Drug Therapy, Combination Erythrocyte Transfusion Fatigue Hemoglobin Hemoglobins - analysis Hemoglobinuria, Paroxysmal - blood Hemoglobinuria, Paroxysmal - drug therapy Hemoglobinuria, Paroxysmal - therapy Hemolysis Humans Injections, Subcutaneous - adverse effects Intravenous administration L-Lactate dehydrogenase Lactic acid Meningitis Middle Aged Monoclonal antibodies Paroxysmal nocturnal hemoglobinuria Patients Peptides - adverse effects Peptides - therapeutic use Peptides, Cyclic Thrombosis
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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