Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy

The use of plant secondary metabolites has gained considerable attention among clinicians in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the roots and rhizomes of Podophyllum species (Berberidaceae) is aryltetralin lignan - podophyllotoxin (PTOX). The purpose...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 158; p. 114145
Main Authors:	Motyka, Sara, Jafernik, Karolina, Ekiert, Halina, Sharifi-Rad, Javad, Calina, Daniela, Al-Omari, Basem, Szopa, Agnieszka, Cho, William C.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01.02.2023
Subjects:	Anticancer mechanisms Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antiviral Agents Humans Lignans - pharmacology Lignans - therapeutic use Neoplasms - drug therapy Pharmacology Phytochemistry Podophyllotoxin Podophyllotoxin - pharmacology Podophyllotoxin - therapeutic use Podophyllotoxin derivatives Tumor cells DPMA Podophyllotoxin derivatives α-SMA Bax-Bcl2 PI3K TUBB3 p-MPM2 CCK-8 CHOP TNBC Da-1 PtoxDpt Etopofos IAA IL-6 PAMAM LD50 Phytochemistry Weel BA ERK Vimentin FDA HCC877GR Podophyllotoxin CNS p-cdc2 Chk1 Chk2 Duplex P-cdc25c HPV CCNB1 IRE1 TGF-β HPLC NSCLC AKT Cdc2 EtopophosTM FasL Bcl2 Cdk1 HCC827 ATM FasR ATR DMSO JNK LC3-II MTT LC-MS/MS NF-κB Bcl-xl DW MRC5 Phospho-PERK PtoxPdp EMA mTOR 4DPG TOPO II 2,4-D MS HCC EMT ER MMP CRC ROS TOP2 ATRA Bcl-2 HLH VM-26 MCL-1 PTOX TLC E-cadherin p-eIF2α GADD153 NSAIDs MPTOX c-MET p-PREK γ-H2AX Tumor cells VEGF STAT3 Pharmacology DENA DPODO Anticancer mechanisms BAP PA PEG VP-16
ISSN:	0753-3322, 1950-6007, 1950-6007
Online Access:	Get full text
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