Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities

Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and phytochemicals. However, with growing interest in the sustainable use of resources and the circular economy to reduce adverse impacts on the environment...

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Published in:	Biomedicine & pharmacotherapy Vol. 146; p. 112498
Main Authors:	Kumar, Manoj, Barbhai, Mrunal D., Hasan, Muzaffar, Punia, Sneh, Dhumal, Sangram, Radha, Rais, Nadeem, Chandran, Deepak, Pandiselvam, R., Kothakota, Anjineyulu, Tomar, Maharishi, Satankar, Varsha, Senapathy, Marisennayya, Anitha, T., Dey, Abhijit, Sayed, Ali A.S., Gadallah, Farouk M., Amarowicz, Ryszard, Mekhemar, Mohamed
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01.02.2022
Subjects:	Anti-Infective Agents - pharmacology Anti-Obesity Agents - pharmacology Antineoplastic Agents - pharmacology Antioxidants - pharmacology Bioactives Biofunctionalities Cardiotonic Agents - pharmacology Flavonoids - pharmacology Hypoglycemic Agents - pharmacology Neuroprotective Agents - pharmacology Onion peel/skin Onions - chemistry Phenols - pharmacology Phytochemicals Phytochemicals - pharmacology Plant Extracts - pharmacology Phytochemicals Onion peel/skin Biofunctionalities Bioactives
ISSN:	0753-3322, 1950-6007, 1950-6007
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Abstract	Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and phytochemicals. However, with growing interest in the sustainable use of resources and the circular economy to reduce adverse impacts on the environment, food processing wastes such as onion peel/skin can be extracted and employed as inputs in developing or reformulating nutrient supplements, and pharmacological drugs. This review highlights major bioactive components, especially total phenolics, total flavonoid, quercetin and its derivatives present in onion peel/skin and their therapeutic applications as cardioprotective, neuroprotective, antiobesity, antidiabetic, anticancer and antimicrobial agents. The present review emphasized that onion peel is one of the important agricultural by-products which is rich in bioactive compounds and can be utilized as health promoting ingredient especially in pharmacological and biomedical fields. Thus, with increasing burden of life style disorders/non-communicable diseases, finding suitable natural alternative for their treatment is one major concern of the researchers and onion peel and its extract can be exploited as a prime ingredient. •Exhaustive review considering extraction of onion peel bioactives and its characterization.•Bifunctionalities associated with onion peel extracts are discussed.•Bioactives exhibit antioxidant, antidiabetic, neuroprotective, and cardioprotective effects.•Onion peel have multifaceted application in fields of biomedicine and pharmaceuticals.
AbstractList	Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and phytochemicals. However, with growing interest in the sustainable use of resources and the circular economy to reduce adverse impacts on the environment, food processing wastes such as onion peel/skin can be extracted and employed as inputs in developing or reformulating nutrient supplements, and pharmacological drugs. This review highlights major bioactive components, especially total phenolics, total flavonoid, quercetin and its derivatives present in onion peel/skin and their therapeutic applications as cardioprotective, neuroprotective, antiobesity, antidiabetic, anticancer and antimicrobial agents. The present review emphasized that onion peel is one of the important agricultural by-products which is rich in bioactive compounds and can be utilized as health promoting ingredient especially in pharmacological and biomedical fields. Thus, with increasing burden of life style disorders/non-communicable diseases, finding suitable natural alternative for their treatment is one major concern of the researchers and onion peel and its extract can be exploited as a prime ingredient.Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and phytochemicals. However, with growing interest in the sustainable use of resources and the circular economy to reduce adverse impacts on the environment, food processing wastes such as onion peel/skin can be extracted and employed as inputs in developing or reformulating nutrient supplements, and pharmacological drugs. This review highlights major bioactive components, especially total phenolics, total flavonoid, quercetin and its derivatives present in onion peel/skin and their therapeutic applications as cardioprotective, neuroprotective, antiobesity, antidiabetic, anticancer and antimicrobial agents. The present review emphasized that onion peel is one of the important agricultural by-products which is rich in bioactive compounds and can be utilized as health promoting ingredient especially in pharmacological and biomedical fields. Thus, with increasing burden of life style disorders/non-communicable diseases, finding suitable natural alternative for their treatment is one major concern of the researchers and onion peel and its extract can be exploited as a prime ingredient. Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and phytochemicals. However, with growing interest in the sustainable use of resources and the circular economy to reduce adverse impacts on the environment, food processing wastes such as onion peel/skin can be extracted and employed as inputs in developing or reformulating nutrient supplements, and pharmacological drugs. This review highlights major bioactive components, especially total phenolics, total flavonoid, quercetin and its derivatives present in onion peel/skin and their therapeutic applications as cardioprotective, neuroprotective, antiobesity, antidiabetic, anticancer and antimicrobial agents. The present review emphasized that onion peel is one of the important agricultural by-products which is rich in bioactive compounds and can be utilized as health promoting ingredient especially in pharmacological and biomedical fields. Thus, with increasing burden of life style disorders/non-communicable diseases, finding suitable natural alternative for their treatment is one major concern of the researchers and onion peel and its extract can be exploited as a prime ingredient. •Exhaustive review considering extraction of onion peel bioactives and its characterization.•Bifunctionalities associated with onion peel extracts are discussed.•Bioactives exhibit antioxidant, antidiabetic, neuroprotective, and cardioprotective effects.•Onion peel have multifaceted application in fields of biomedicine and pharmaceuticals. Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and phytochemicals. However, with growing interest in the sustainable use of resources and the circular economy to reduce adverse impacts on the environment, food processing wastes such as onion peel/skin can be extracted and employed as inputs in developing or reformulating nutrient supplements, and pharmacological drugs. This review highlights major bioactive components, especially total phenolics, total flavonoid, quercetin and its derivatives present in onion peel/skin and their therapeutic applications as cardioprotective, neuroprotective, antiobesity, antidiabetic, anticancer and antimicrobial agents. The present review emphasized that onion peel is one of the important agricultural by-products which is rich in bioactive compounds and can be utilized as health promoting ingredient especially in pharmacological and biomedical fields. Thus, with increasing burden of life style disorders/non-communicable diseases, finding suitable natural alternative for their treatment is one major concern of the researchers and onion peel and its extract can be exploited as a prime ingredient.
ArticleNumber	112498
Author	Anitha, T. Dhumal, Sangram Tomar, Maharishi Dey, Abhijit Sayed, Ali A.S. Senapathy, Marisennayya Kumar, Manoj Rais, Nadeem Gadallah, Farouk M. Mekhemar, Mohamed Kothakota, Anjineyulu Punia, Sneh Pandiselvam, R. Chandran, Deepak Satankar, Varsha Barbhai, Mrunal D. Hasan, Muzaffar Amarowicz, Ryszard Radha
Author_xml	– sequence: 1 givenname: Manoj surname: Kumar fullname: Kumar, Manoj email: manoj.kumar13@icar.gov.in, manojkumarpuniya114@gmail.com organization: Chemical and Biochemical Processing Division, ICAR – Central institute for Research on Cotton Technology, Mumbai 400019, India – sequence: 2 givenname: Mrunal D. surname: Barbhai fullname: Barbhai, Mrunal D. organization: Chemical and Biochemical Processing Division, ICAR – Central institute for Research on Cotton Technology, Mumbai 400019, India – sequence: 3 givenname: Muzaffar surname: Hasan fullname: Hasan, Muzaffar organization: Agro Produce Processing Division, ICAR—Central Institute of Agricultural Engineering, Bhopal 462038, India – sequence: 4 givenname: Sneh surname: Punia fullname: Punia, Sneh organization: Department of Food, Nutrition and Packaging Sciences, Clemson University, Clemson, SC 29634, USA – sequence: 5 givenname: Sangram surname: Dhumal fullname: Dhumal, Sangram organization: Division of Horticulture, RCSM College of Agriculture, Kolhapur 416004, India – sequence: 6 surname: Radha fullname: Radha organization: School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India – sequence: 7 givenname: Nadeem surname: Rais fullname: Rais, Nadeem organization: Department of Pharmacy, Bhagwant University, Ajmer, Rajasthan 305004, India – sequence: 8 givenname: Deepak surname: Chandran fullname: Chandran, Deepak organization: Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, Tamil Nadu, India – sequence: 9 givenname: R. surname: Pandiselvam fullname: Pandiselvam, R. organization: Division of Physiology, Biochemistry and Post-Harvest Technology, ICAR – Central Plantation Crops Research Institute (CPCRI), Kasaragod, 671 124 Kerala, India – sequence: 10 givenname: Anjineyulu surname: Kothakota fullname: Kothakota, Anjineyulu organization: Agro-Processing & Technology Division, CSIR – National Institute for Interdisciplinary Science and Technology (NIIST), Trivandrum - 695091, Kerala, India – sequence: 11 givenname: Maharishi surname: Tomar fullname: Tomar, Maharishi organization: Seed Technology Division, ICAR – Indian Grassland and Fodder Research Institute, Jhansi, India – sequence: 12 givenname: Varsha surname: Satankar fullname: Satankar, Varsha organization: Ginning Training Centre, ICAR – Central Institute for Research on Cotton Technology, Nagpur, Maharashtra, India – sequence: 13 givenname: Marisennayya surname: Senapathy fullname: Senapathy, Marisennayya email: drsenapathy@wsu.edu.et organization: Department of Rural Development and Agricultural Extension, College of Agriculture, Wolaita Sodo University, SNNPR, Wolaita Sodo, Ethiopia – sequence: 14 givenname: T. surname: Anitha fullname: Anitha, T. organization: Department of Postharvest Technology, Horticultural College and Research Institute, Periyakulam 625604, India – sequence: 15 givenname: Abhijit surname: Dey fullname: Dey, Abhijit organization: Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, India – sequence: 16 givenname: Ali A.S. surname: Sayed fullname: Sayed, Ali A.S. organization: Botany Department, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt – sequence: 17 givenname: Farouk M. surname: Gadallah fullname: Gadallah, Farouk M. organization: Botany Department, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt – sequence: 18 givenname: Ryszard surname: Amarowicz fullname: Amarowicz, Ryszard organization: Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland – sequence: 19 givenname: Mohamed surname: Mekhemar fullname: Mekhemar, Mohamed email: mekhemar@konspar.uni-kiel.de organization: Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrecht’s University, 24105 Kiel, Germany
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Keywords	Phytochemicals Onion peel/skin Biofunctionalities Bioactives
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Snippet	Huge quantities of byproducts/wastes generated in onion processing are usually discarded, but they are excellent sources of bioactive compounds and...
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SubjectTerms	Anti-Infective Agents - pharmacology Anti-Obesity Agents - pharmacology Antineoplastic Agents - pharmacology Antioxidants - pharmacology Bioactives Biofunctionalities Cardiotonic Agents - pharmacology Flavonoids - pharmacology Hypoglycemic Agents - pharmacology Neuroprotective Agents - pharmacology Onion peel/skin Onions - chemistry Phenols - pharmacology Phytochemicals Phytochemicals - pharmacology Plant Extracts - pharmacology
Title	Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities
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