Diabetic kidney disease: An overview of prevalence, risk factors, and biomarkers
Diabetic kidney disease (DKD) is a major public health problem characterized by elevated urine albumin excretion or reduced glomerular filtration rate or both. The pathophysiology of DKD involves various pathways like hemodynamic, metabolic, and inflammatory pathways. Increase in reactive oxygen spe...
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| Vydáno v: | Clinical epidemiology and global health Ročník 9; s. 2 - 6 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Elsevier B.V
01.01.2021
Elsevier |
| Témata: | |
| ISSN: | 2213-3984, 2213-3984 |
| On-line přístup: | Získat plný text |
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| Abstract | Diabetic kidney disease (DKD) is a major public health problem characterized by elevated urine albumin excretion or reduced glomerular filtration rate or both. The pathophysiology of DKD involves various pathways like hemodynamic, metabolic, and inflammatory pathways. Increase in reactive oxygen species formation induced by hyperglycemia through activation of electron transport chain considered as the initiators in the development of diabetes complications. Prevalence of DKD is raising continuously with disparate growth in low to middle-income countries and under-recognized as a global burden of disease. DKD imposes an enormous humanistic, economic, and societal burden. DKD in the initial stage is often undiagnosed until the manifestations of serious complications. The major hurdle in the early diagnosis is limited knowledge, unroutine screening. Timely diagnosis and appropriate interventions are the best approaches to deal with this catastrophic condition. Early diagnosis can have lifetime benefits by controlling the progression of the disease, increasing life expectancy, decreasing the humanistic and economic burden. Even after all these benefits; DKD cases are diagnosed when the condition worsens. Non-availability of potential diagnostic biomarkers is the main barrier to the early diagnosis of DKD. The present review highlights the worldwide prevalence, risk factors, and potential biomarkers for the early detection of DKD. |
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| AbstractList | Diabetic kidney disease (DKD) is a major public health problem characterized by elevated urine albumin excretion or reduced glomerular filtration rate or both. The pathophysiology of DKD involves various pathways like hemodynamic, metabolic, and inflammatory pathways. Increase in reactive oxygen species formation induced by hyperglycemia through activation of electron transport chain considered as the initiators in the development of diabetes complications. Prevalence of DKD is raising continuously with disparate growth in low to middle-income countries and under-recognized as a global burden of disease. DKD imposes an enormous humanistic, economic, and societal burden. DKD in the initial stage is often undiagnosed until the manifestations of serious complications. The major hurdle in the early diagnosis is limited knowledge, unroutine screening. Timely diagnosis and appropriate interventions are the best approaches to deal with this catastrophic condition. Early diagnosis can have lifetime benefits by controlling the progression of the disease, increasing life expectancy, decreasing the humanistic and economic burden. Even after all these benefits; DKD cases are diagnosed when the condition worsens. Non-availability of potential diagnostic biomarkers is the main barrier to the early diagnosis of DKD. The present review highlights the worldwide prevalence, risk factors, and potential biomarkers for the early detection of DKD. |
| Author | Habib, Anwar Najmi, Abul Kalam Chand Jamali, Mohammad Hussain, Salman Hussain, Md Sarfaraj Akhtar, Mohd |
| Author_xml | – sequence: 1 givenname: Salman surname: Hussain fullname: Hussain, Salman organization: Department of Pharmaceutical Medicine (Division of Pharmacology), School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India – sequence: 2 givenname: Mohammad surname: Chand Jamali fullname: Chand Jamali, Mohammad organization: Department of Health and Medical Sciences, Khawarizmi International College, Abu Dhabi, United Arab Emirates – sequence: 3 givenname: Anwar surname: Habib fullname: Habib, Anwar email: anwer_habib@rediffmail.com organization: Department of Medicine, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India – sequence: 4 givenname: Md Sarfaraj surname: Hussain fullname: Hussain, Md Sarfaraj organization: Department of Pharmacognosy & Phytochemistry, R.V Northland Institute of Pharmacy, U.P, India – sequence: 5 givenname: Mohd surname: Akhtar fullname: Akhtar, Mohd organization: Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India – sequence: 6 givenname: Abul Kalam surname: Najmi fullname: Najmi, Abul Kalam organization: Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India |
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| Keywords | Prevalence Biomarkers Diabetes kidney disease Diabetic nephropathy Chronic kidney disease Epidemiology India |
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