Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180

In recent years, research into synthetic lethality and how it can be exploited in cancer treatments has emerged as major focus in cancer research. However, the lack of a simple to use, sensitive and standardised assay to test for synthetic interactions has been slowing the efforts. Here we present a...

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Bibliographic Details
Published in:	DNA repair Vol. 46; pp. 47 - 54
Main Authors:	Hopkins, Suzanna R., McGregor, Grant A., Murray, Johanne M., Downs, Jessica A., Savic, Velibor
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.10.2016
Subjects:	Cell Line, Tumor Cell Survival - radiation effects DNA-Binding Proteins Fluorescent Dyes - metabolism Gene Expression High-Throughput Screening Assays Histone Acetyltransferases - antagonists & inhibitors Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Humans Lysine Acetyltransferase 5 Micronucleus Tests Molecular Imaging Nuclear Proteins - deficiency Nuclear Proteins - genetics Osteoblasts - metabolism Osteoblasts - pathology Osteoblasts - radiation effects Radiation Tolerance RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Staining and Labeling - methods Synthetic Lethal Mutations Transcription Factors - deficiency Transcription Factors - genetics
ISSN:	1568-7864, 1568-7856
Online Access:	Get full text
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