Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations

Tim21, a subunit of a highly dynamic translocase of the inner mitochondrial membrane (TIM23) complex, translocates proteins by interacting with subunits in the translocase of the outer membrane (TOM) complex and Tim23 channel in the TIM23 complex. A loop segment in Tim21, which is in close proximity...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1864; no. 2; p. 129417
Main Authors:	Srivastava, Arpita, Bala, Siqin, Motomura, Hajime, Kohda, Daisuke, Tama, Florence, Miyashita, Osamu
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2020
Subjects:	binding sites computational methodology Crystal contact-free space crystal structure energy enzymes Gibbs free energy Loop modeling mitochondrial membrane Molecular dynamics multidimensional scaling nuclear magnetic resonance spectroscopy physiological transport proteins simulation models Tim21 X-radiation MD_NMR Tim21 L2 Molecular dynamics mdm1-mdm10 RMSF Loop modeling RMSD m1-m10 IMS clus1-clus10 Crystal contact-free space NMR CCFS MD_CCFS MD MD_Xray MBP Xray MDS
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!