Downregulation of microRNA-27b-3p via aberrant DNA methylation contributes to malignant behavior of gastric cancer cells by targeting GSPT1

•MiR-27b-3p was downregulated in gastric cancer tissues and cells.•MiR-27b-3p can suppress gastric cancer cell proliferation, invasion, and migration.•MiR-27b-3p was downregulated by aberrant DNA methylation in gastric cancer.•GSPT1 was negatively regulated by miR-27b-3p via combining the 3′-untrans...

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Vydané v:	Biomedicine & pharmacotherapy Ročník 119; s. 109417
Hlavní autori:	Zhang, Cheng, Zou, Ying, Dai, Dong-Qiu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	France Elsevier Masson SAS 01.11.2019
Predmet:	Aberrant DNA methylation Base Sequence Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics DNA Methylation - genetics Down-Regulation - genetics Female Gastric cancer Gene Expression Regulation, Neoplastic GSPT1 Humans Male MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-27b-3p Neoplasm Invasiveness Neoplasm Staging Peptide Termination Factors - genetics Peptide Termination Factors - metabolism Promoter Regions, Genetic Stomach Neoplasms - genetics Stomach Neoplasms - pathology Survival Analysis miR-27b-3p Aberrant DNA methylation Gastric cancer GSPT1
ISSN:	0753-3322, 1950-6007, 1950-6007
On-line prístup:	Získať plný text
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