Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p

MicroRNA-221-3p (miR-221-3p) is associated with both metabolic diseases and cancers. However, its role in terminal adipocyte differentiation and lipid metabolism are uncharacterized. miR-221-3p or its inhibitor was transfected into differentiating or mature human adipocytes. Triglyceride (TG) conten...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. Molecular and cell biology of lipids Vol. 1866; no. 1; p. 158841
Main Authors:	Ahonen, Maria A., Asghar, Muhammad Yasir, Parviainen, Suvi J., Liebisch, Gerhard, Höring, Marcus, Leidenius, Marjut, Fischer-Posovszky, Pamela, Wabitsch, Martin, Mikkola, Tomi S., Törnquist, Kid, Savolainen-Peltonen, Hanna, Haridas, P.A. Nidhina, Olkkonen, Vesa M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.01.2021
Subjects:	14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism adipocytes Adipocytes - metabolism Adipocytes - pathology Adipogenesis - genetics Adiponectin - genetics Adiponectin - metabolism Adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology Adult Aged ATP citrate synthase Breast cancer breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Case-Control Studies Cell Differentiation Cell Proliferation ceramides Ceramides - classification Ceramides - metabolism Diacylglycerol O-Acyltransferase - genetics Diacylglycerol O-Acyltransferase - metabolism diacylglycerols fas Receptor - genetics fas Receptor - metabolism Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Female Gene Expression Regulation, Neoplastic Humans Lipase - genetics Lipase - metabolism Lipid Droplets - metabolism Lipid storage Lipogenesis Mammary Glands, Human - metabolism Mammary Glands, Human - pathology MCF-7 Cells microRNA MicroRNAs - agonists MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Middle Aged neoplasm progression Signal Transduction Sphingolipid Sphingolipids - classification Sphingolipids - metabolism sphingomyelins Stearoyl-CoA Desaturase - genetics Stearoyl-CoA Desaturase - metabolism triacylglycerols Triglycerides - classification Triglycerides - metabolism Lipid storage Sphingolipid microRNA Breast cancer Adipose tissue Lipogenesis
ISSN:	1388-1981, 1879-2618, 1879-2618
Online Access:	Get full text
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