Gut Microbiota in Multiple Sclerosis: Possible Influence of Immunomodulators

Objectives Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in patients with multiple sclerosis and healthy controls and evaluated the influence of glatiramer acetate and vitamin D treatment on the microbiota....

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Veröffentlicht in:	Journal of investigative medicine Jg. 63; H. 5; S. 729 - 734
Hauptverfasser:	Cantarel, Brandi L., Waubant, Emmanuelle, Chehoud, Christel, Kuczynski, Justin, DeSantis, Todd Z., Warrington, Janet, Venkatesan, Arun, Fraser, Claire M., Mowry, Ellen M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Los Angeles, CA SAGE Publications 01.06.2015
Schlagworte:	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Adult Cholecalciferol - pharmacology Cholecalciferol - therapeutic use Dietary Supplements Female Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology Glatiramer Acetate - pharmacology Glatiramer Acetate - therapeutic use Humans Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Middle Aged Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - drug therapy Pilot Projects gut microbiome autoimmunity glatiramer acetate multiple sclerosis vitamin D
ISSN:	1081-5589, 1708-8267
Online-Zugang:	Volltext
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Abstract	Objectives Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in patients with multiple sclerosis and healthy controls and evaluated the influence of glatiramer acetate and vitamin D treatment on the microbiota. Methods Subjects were otherwise healthy white women with or without relapsing-remitting multiple sclerosis who were vitamin D insufficient. Patients with multiple sclerosis were untreated or were receiving glatiramer acetate. Subjects collected stool at baseline and after 90 days of vitamin D3 (5000 IU/d) supplementation. The abundance of operational taxonomic units was evaluated by hybridization of 16S rRNA to a DNA microarray. Results While there was overlap of gut bacterial communities, the abundance of some operational taxonomic units, including Faecalibacterium, was lower in patients with multiple sclerosis. Glatiramer acetate–treated patients with multiple sclerosis showed differences in community composition compared with untreated subjects, including Bacteroidaceae, Faecalibacterium, Ruminococcus, Lactobacillaceae, Clostridium, and other Clostridiales. Compared with the other groups, untreated patients with multiple sclerosis had an increase in the Akkermansia, Faecalibacterium, and Coprococcus genera after vitamin D supplementation. Conclusions While overall bacterial communities were similar, specific operational taxonomic units differed between healthy controls and patients with multiple sclerosis. Glatiramer acetate and vitamin D supplementation were associated with differences or changes in the microbiota. This study was exploratory, and larger studies are needed to confirm these preliminary results.
AbstractList	OBJECTIVESDifferences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in patients with multiple sclerosis and healthy controls and evaluated the influence of glatiramer acetate and vitamin D treatment on the microbiota.METHODSSubjects were otherwise healthy white women with or without relapsing-remitting multiple sclerosis who were vitamin D insufficient. Patients with multiple sclerosis were untreated or were receiving glatiramer acetate. Subjects collected stool at baseline and after 90 days of vitamin D3 (5000 IU/d) supplementation. The abundance of operational taxonomic units was evaluated by hybridization of 16S rRNA to a DNA microarray.RESULTSWhile there was overlap of gut bacterial communities, the abundance of some operational taxonomic units, including Faecalibacterium, was lower in patients with multiple sclerosis. Glatiramer acetate-treated patients with multiple sclerosis showed differences in community composition compared with untreated subjects, including Bacteroidaceae, Faecalibacterium, Ruminococcus, Lactobacillaceae, Clostridium, and other Clostridiales. Compared with the other groups, untreated patients with multiple sclerosis had an increase in the Akkermansia, Faecalibacterium, and Coprococcus genera after vitamin D supplementation.CONCLUSIONSWhile overall bacterial communities were similar, specific operational taxonomic units differed between healthy controls and patients with multiple sclerosis. Glatiramer acetate and vitamin D supplementation were associated with differences or changes in the microbiota. This study was exploratory, and larger studies are needed to confirm these preliminary results. Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in patients with multiple sclerosis and healthy controls and evaluated the influence of glatiramer acetate and vitamin D treatment on the microbiota. Subjects were otherwise healthy white women with or without relapsing-remitting multiple sclerosis who were vitamin D insufficient. Patients with multiple sclerosis were untreated or were receiving glatiramer acetate. Subjects collected stool at baseline and after 90 days of vitamin D3 (5000 IU/d) supplementation. The abundance of operational taxonomic units was evaluated by hybridization of 16S rRNA to a DNA microarray. While there was overlap of gut bacterial communities, the abundance of some operational taxonomic units, including Faecalibacterium, was lower in patients with multiple sclerosis. Glatiramer acetate-treated patients with multiple sclerosis showed differences in community composition compared with untreated subjects, including Bacteroidaceae, Faecalibacterium, Ruminococcus, Lactobacillaceae, Clostridium, and other Clostridiales. Compared with the other groups, untreated patients with multiple sclerosis had an increase in the Akkermansia, Faecalibacterium, and Coprococcus genera after vitamin D supplementation. While overall bacterial communities were similar, specific operational taxonomic units differed between healthy controls and patients with multiple sclerosis. Glatiramer acetate and vitamin D supplementation were associated with differences or changes in the microbiota. This study was exploratory, and larger studies are needed to confirm these preliminary results. Objectives Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in patients with multiple sclerosis and healthy controls and evaluated the influence of glatiramer acetate and vitamin D treatment on the microbiota. Methods Subjects were otherwise healthy white women with or without relapsing-remitting multiple sclerosis who were vitamin D insufficient. Patients with multiple sclerosis were untreated or were receiving glatiramer acetate. Subjects collected stool at baseline and after 90 days of vitamin D3 (5000 IU/d) supplementation. The abundance of operational taxonomic units was evaluated by hybridization of 16S rRNA to a DNA microarray. Results While there was overlap of gut bacterial communities, the abundance of some operational taxonomic units, including Faecalibacterium, was lower in patients with multiple sclerosis. Glatiramer acetate–treated patients with multiple sclerosis showed differences in community composition compared with untreated subjects, including Bacteroidaceae, Faecalibacterium, Ruminococcus, Lactobacillaceae, Clostridium, and other Clostridiales. Compared with the other groups, untreated patients with multiple sclerosis had an increase in the Akkermansia, Faecalibacterium, and Coprococcus genera after vitamin D supplementation. Conclusions While overall bacterial communities were similar, specific operational taxonomic units differed between healthy controls and patients with multiple sclerosis. Glatiramer acetate and vitamin D supplementation were associated with differences or changes in the microbiota. This study was exploratory, and larger studies are needed to confirm these preliminary results.
Author	Mowry, Ellen M. Waubant, Emmanuelle Fraser, Claire M. Kuczynski, Justin Warrington, Janet Cantarel, Brandi L. Venkatesan, Arun DeSantis, Todd Z. Chehoud, Christel
Author_xml	– sequence: 1 givenname: Brandi L. surname: Cantarel fullname: Cantarel, Brandi L. organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 2 givenname: Emmanuelle surname: Waubant fullname: Waubant, Emmanuelle organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 3 givenname: Christel surname: Chehoud fullname: Chehoud, Christel organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 4 givenname: Justin surname: Kuczynski fullname: Kuczynski, Justin organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 5 givenname: Todd Z. surname: DeSantis fullname: DeSantis, Todd Z. organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 6 givenname: Janet surname: Warrington fullname: Warrington, Janet organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 7 givenname: Arun surname: Venkatesan fullname: Venkatesan, Arun organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 8 givenname: Claire M. surname: Fraser fullname: Fraser, Claire M. organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD – sequence: 9 givenname: Ellen M. surname: Mowry fullname: Mowry, Ellen M. organization: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25775034$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1016/j.tim.2013.01.001 10.1186/1471-2180-11-7 10.1177/1535370214523890 10.3389/fmicb.2011.00166 10.1073/pnas.082099299 10.1212/WNL.55.6.842 10.1126/science.1195979 10.1002/ana.22344 10.3945/jn.113.180794 10.1007/s11739-010-0451-0 10.1038/nature10554 10.1111/apt.12404 10.1371/journal.pone.0025792 10.1128/AEM.03006-05 10.1073/pnas.0804812105 10.1002/eji.201242758 10.1111/j.1574-6968.2002.tb11467.x 10.1124/jpet.106.103192 10.1371/journal.pone.0076520
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Keywords	gut microbiome autoimmunity glatiramer acetate multiple sclerosis vitamin D
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References	Sokol, Pigneur, Watterlot 2008; 105 Fortenberry 2013; 21 Yao, Han, Liang 2013; 43 Ooi, Li, Rogers 2013; 143 Pryde, Duncan, Hold 2002; 217 Hazen, Dubinsky, DeSantis 2010; 330 Thorkildsen, Nwosu, Avershina 2013 Cantorna, McDaniel, Bora 2014; 239 Ochoa-Reparaz, Mielcarz, Begum-Haque, Kasper 2011; 69 Brown, Davis-Richardson, Giongo 2011; 6 Granieri, Casetta, Govoni 2000; 55 Berer, Mues, Koutrolos 2011; 479 Walker, Sanderson, Churcher 2011; 11 Kang, Ban, Choi 2013; 8 Aharoni, Kayhan, Brenner 2006; 318 Tibshirani, Hastie, Narasimhan 2002; 99 Stanghellini, Barbara, Cremon 2010; 5 Siaw, Hart 2013; 38 Derrien, van Baarlen, Hooiveld 2011; 2 DeSantis, Hugenholtz, Larsen 2006; 72 bibr2-JIM.0000000000000192 bibr16-JIM.0000000000000192 bibr8-JIM.0000000000000192 Thorkildsen LT (bibr18-JIM.0000000000000192) 2013 bibr20-JIM.0000000000000192 bibr1-JIM.0000000000000192 bibr15-JIM.0000000000000192 bibr6-JIM.0000000000000192 bibr14-JIM.0000000000000192 bibr7-JIM.0000000000000192 bibr9-JIM.0000000000000192 bibr4-JIM.0000000000000192 bibr13-JIM.0000000000000192 bibr19-JIM.0000000000000192 bibr5-JIM.0000000000000192 bibr17-JIM.0000000000000192 bibr3-JIM.0000000000000192 bibr12-JIM.0000000000000192 bibr10-JIM.0000000000000192 bibr11-JIM.0000000000000192 10994006 - Neurology. 2000 Sep 26;55(6):842-8 24348539 - Gastroenterol Res Pract. 2013;2013:636785 23566633 - Trends Microbiol. 2013 Apr;21(4):165-6 24668555 - Exp Biol Med (Maywood). 2014 Nov;239(11):1524-30 16624971 - J Pharmacol Exp Ther. 2006 Jul;318(1):68-78 23937459 - Aliment Pharmacol Ther. 2013 Sep;38(5):551 20736401 - Science. 2010 Oct 8;330(6001):204-8 23966330 - J Nutr. 2013 Oct;143(10):1679-86 21387369 - Ann Neurol. 2011 Feb;69(2):240-7 16820507 - Appl Environ Microbiol. 2006 Jul;72(7):5069-72 18936492 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6 24204633 - PLoS One. 2013;8(10):e76520 20865476 - Intern Emerg Med. 2010 Oct;5 Suppl 1:S57-63 22043294 - PLoS One. 2011;6(10):e25792 12480096 - FEMS Microbiol Lett. 2002 Dec 17;217(2):133-9 12011421 - Proc Natl Acad Sci U S A. 2002 May 14;99(10):6567-72 21904534 - Front Microbiol. 2011 Aug 01;2:166 23002042 - Eur J Immunol. 2013 Jan;43(1):125-36 21219646 - BMC Microbiol. 2011;11:7 22031325 - Nature. 2011 Nov 24;479(7374):538-41
References_xml	– volume: 5 start-page: S57 year: 2010 end-page: S63 article-title: Gut microbiota and related diseases: clinical features publication-title: Intern Emerg Med – volume: 8 start-page: e76520 year: 2013 article-title: Extracellular vesicles derived from gut microbiota, especially , protect the progression of dextran sulfate sodium–induced colitis publication-title: PLoS One – volume: 239 start-page: 1524 year: 2014 end-page: 1530 article-title: Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease publication-title: Exp Biol Med – volume: 99 start-page: 6567 year: 2002 end-page: 6572 article-title: Diagnosis of multiple cancer types by shrunken centroids of gene expression publication-title: Proc Natl Acad Sci U S A – volume: 143 start-page: 1679 year: 2013 end-page: 1686 article-title: Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate–induced colitis publication-title: J Nutr – volume: 69 start-page: 240 year: 2011 end-page: 247 article-title: Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease publication-title: Ann Neurol – volume: 72 start-page: 5069 year: 2006 end-page: 5072 article-title: Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB publication-title: Appl Environ Microbiol – start-page: 636785 year: 2013 article-title: Dominant fecal microbiota in newly diagnosed untreated inflammatory bowel disease publication-title: Gastroenterol Res Pract – volume: 2 start-page: 166 year: 2011 article-title: Modulation of mucosal immune response, tolerance, and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila publication-title: Front Microbiol – volume: 318 start-page: 68 year: 2006 end-page: 78 article-title: Immunomodulatory therapeutic effect of glatiramer acetate on several murine models of inflammatory bowel disease publication-title: J Pharmacol Exp Ther – volume: 217 start-page: 133 year: 2002 end-page: 139 article-title: The microbiology of butyrate formation in the human colon publication-title: FEMS Microbiol Lett – volume: 11 start-page: 7 year: 2011 article-title: High throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease publication-title: BMC Microbiol – volume: 479 start-page: 538 year: 2011 end-page: 541 article-title: Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination publication-title: Nature – volume: 330 start-page: 204 year: 2010 end-page: 208 article-title: Deep-sea oil plume enriches indigenous oil-degrading bacteria publication-title: Science – volume: 55 start-page: 842 year: 2000 end-page: 848 article-title: The increasing incidence and prevalence of MS in a Sardinian province publication-title: Neurology – volume: 43 start-page: 125 year: 2013 end-page: 136 article-title: Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1–restricted CD8(+) regulatory cells publication-title: Eur J Immunol – volume: 105 start-page: 16731 year: 2008 end-page: 16736 article-title: Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients publication-title: Proc Natl Acad Sci U S A – volume: 38 start-page: 551 year: 2013 article-title: Commentary:is a potential treatment for maintaining remission in ulcerative colitis? publication-title: Aliment Pharmacol Ther – volume: 21 start-page: 165 year: 2013 end-page: 166 article-title: The uses of race and ethnicity in human microbiome research publication-title: Trends Microbiol – volume: 6 start-page: e25792 year: 2011 article-title: Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes publication-title: PLoS One – ident: bibr20-JIM.0000000000000192 doi: 10.1016/j.tim.2013.01.001 – ident: bibr17-JIM.0000000000000192 doi: 10.1186/1471-2180-11-7 – ident: bibr15-JIM.0000000000000192 doi: 10.1177/1535370214523890 – ident: bibr13-JIM.0000000000000192 doi: 10.3389/fmicb.2011.00166 – ident: bibr7-JIM.0000000000000192 doi: 10.1073/pnas.082099299 – ident: bibr1-JIM.0000000000000192 doi: 10.1212/WNL.55.6.842 – ident: bibr5-JIM.0000000000000192 doi: 10.1126/science.1195979 – start-page: 636785 year: 2013 ident: bibr18-JIM.0000000000000192 publication-title: Gastroenterol Res Pract – ident: bibr3-JIM.0000000000000192 doi: 10.1002/ana.22344 – ident: bibr16-JIM.0000000000000192 doi: 10.3945/jn.113.180794 – ident: bibr2-JIM.0000000000000192 doi: 10.1007/s11739-010-0451-0 – ident: bibr4-JIM.0000000000000192 doi: 10.1038/nature10554 – ident: bibr11-JIM.0000000000000192 doi: 10.1111/apt.12404 – ident: bibr19-JIM.0000000000000192 doi: 10.1371/journal.pone.0025792 – ident: bibr6-JIM.0000000000000192 doi: 10.1128/AEM.03006-05 – ident: bibr10-JIM.0000000000000192 doi: 10.1073/pnas.0804812105 – ident: bibr9-JIM.0000000000000192 doi: 10.1002/eji.201242758 – ident: bibr12-JIM.0000000000000192 doi: 10.1111/j.1574-6968.2002.tb11467.x – ident: bibr8-JIM.0000000000000192 doi: 10.1124/jpet.106.103192 – ident: bibr14-JIM.0000000000000192 doi: 10.1371/journal.pone.0076520 – reference: 22031325 - Nature. 2011 Nov 24;479(7374):538-41 – reference: 10994006 - Neurology. 2000 Sep 26;55(6):842-8 – reference: 16820507 - Appl Environ Microbiol. 2006 Jul;72(7):5069-72 – reference: 24204633 - PLoS One. 2013;8(10):e76520 – reference: 18936492 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6 – reference: 12480096 - FEMS Microbiol Lett. 2002 Dec 17;217(2):133-9 – reference: 24668555 - Exp Biol Med (Maywood). 2014 Nov;239(11):1524-30 – reference: 21219646 - BMC Microbiol. 2011;11:7 – reference: 23966330 - J Nutr. 2013 Oct;143(10):1679-86 – reference: 23566633 - Trends Microbiol. 2013 Apr;21(4):165-6 – reference: 24348539 - Gastroenterol Res Pract. 2013;2013:636785 – reference: 12011421 - Proc Natl Acad Sci U S A. 2002 May 14;99(10):6567-72 – reference: 21387369 - Ann Neurol. 2011 Feb;69(2):240-7 – reference: 23002042 - Eur J Immunol. 2013 Jan;43(1):125-36 – reference: 16624971 - J Pharmacol Exp Ther. 2006 Jul;318(1):68-78 – reference: 20736401 - Science. 2010 Oct 8;330(6001):204-8 – reference: 23937459 - Aliment Pharmacol Ther. 2013 Sep;38(5):551 – reference: 20865476 - Intern Emerg Med. 2010 Oct;5 Suppl 1:S57-63 – reference: 22043294 - PLoS One. 2011;6(10):e25792 – reference: 21904534 - Front Microbiol. 2011 Aug 01;2:166
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Snippet	Objectives Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in... Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in patients with... OBJECTIVESDifferences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in...
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SubjectTerms	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Adult Cholecalciferol - pharmacology Cholecalciferol - therapeutic use Dietary Supplements Female Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology Glatiramer Acetate - pharmacology Glatiramer Acetate - therapeutic use Humans Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Middle Aged Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - drug therapy Pilot Projects
Title	Gut Microbiota in Multiple Sclerosis: Possible Influence of Immunomodulators
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