Cerebral Energy Status and Altered Metabolism in Early Brain Injury After Aneurysmal Subarachnoid Hemorrhage: A Prospective 31P-MRS Pilot Study
Acute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall neurological outcome. However, direct detection of these alterations is limited. Phosphorous magnetic resonance spectroscopy (31P-MRS) is a mole...
Uloženo v:
| Vydáno v: | Frontiers in neurology Ročník 13; s. 831537 |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Switzerland
Frontiers Media S.A
28.02.2022
|
| Témata: | |
| ISSN: | 1664-2295, 1664-2295 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Acute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall neurological outcome. However, direct detection of these alterations is limited. Phosphorous magnetic resonance spectroscopy (31P-MRS) is a molecular-based advanced neuroimaging technique allowing measurements of pathophysiological processes and tissue metabolism based on various phosphorous compound metabolites. This method may provide objective assessment of both primary and secondary changes.
The aim of this pilot study was to evaluate the feasibility and the diagnostic potential of early 31P-MRS in aSAH.
Patients with aSAH treated for ruptured aneurysms between July 2016 and October 2017 were prospectively included in the study. 3-Tesla-MRI including 31P-MRS was performed within the first 72 h after hemorrhage. Data of the vascular territories of the anterior, middle, and posterior cerebral arteries (ACA, MCA, PCA) and the basal ganglia were separately analyzed and compared with data of a healthy age- and sex-matched control group. Phosphorous compound metabolites were quantified, and ratios of these metabolites were further evaluated. Influence of treatment modality, clinical conditions, and analgosedation were analyzed.
Data of 13 patients were analyzed. 31P-MRS showed significant changes in cerebral energy metabolism after aSAH in all cerebrovascular territories. Both PCr/ATP and PCr/Pi ratio were notably increased (
< 0.001). Also, Pi/ATP was significantly decreased in all cerebrovascular territories (
= 0.014). PME/PDE ratio was overall significant decreased (
< 0.001).
31P-MRS is a promising non-invasive imaging tool for the assessment of changes in energy metabolism after aSAH. It allows a detailed insight into EBI and seems to harbor a high potential for clinical practice. |
|---|---|
| AbstractList | Acute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall neurological outcome. However, direct detection of these alterations is limited. Phosphorous magnetic resonance spectroscopy (31P-MRS) is a molecular-based advanced neuroimaging technique allowing measurements of pathophysiological processes and tissue metabolism based on various phosphorous compound metabolites. This method may provide objective assessment of both primary and secondary changes.
The aim of this pilot study was to evaluate the feasibility and the diagnostic potential of early 31P-MRS in aSAH.
Patients with aSAH treated for ruptured aneurysms between July 2016 and October 2017 were prospectively included in the study. 3-Tesla-MRI including 31P-MRS was performed within the first 72 h after hemorrhage. Data of the vascular territories of the anterior, middle, and posterior cerebral arteries (ACA, MCA, PCA) and the basal ganglia were separately analyzed and compared with data of a healthy age- and sex-matched control group. Phosphorous compound metabolites were quantified, and ratios of these metabolites were further evaluated. Influence of treatment modality, clinical conditions, and analgosedation were analyzed.
Data of 13 patients were analyzed. 31P-MRS showed significant changes in cerebral energy metabolism after aSAH in all cerebrovascular territories. Both PCr/ATP and PCr/Pi ratio were notably increased (
< 0.001). Also, Pi/ATP was significantly decreased in all cerebrovascular territories (
= 0.014). PME/PDE ratio was overall significant decreased (
< 0.001).
31P-MRS is a promising non-invasive imaging tool for the assessment of changes in energy metabolism after aSAH. It allows a detailed insight into EBI and seems to harbor a high potential for clinical practice. BackgroundAcute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall neurological outcome. However, direct detection of these alterations is limited. Phosphorous magnetic resonance spectroscopy (31P-MRS) is a molecular-based advanced neuroimaging technique allowing measurements of pathophysiological processes and tissue metabolism based on various phosphorous compound metabolites. This method may provide objective assessment of both primary and secondary changes.ObjectiveThe aim of this pilot study was to evaluate the feasibility and the diagnostic potential of early 31P-MRS in aSAH.MethodsPatients with aSAH treated for ruptured aneurysms between July 2016 and October 2017 were prospectively included in the study. 3-Tesla-MRI including 31P-MRS was performed within the first 72 h after hemorrhage. Data of the vascular territories of the anterior, middle, and posterior cerebral arteries (ACA, MCA, PCA) and the basal ganglia were separately analyzed and compared with data of a healthy age- and sex-matched control group. Phosphorous compound metabolites were quantified, and ratios of these metabolites were further evaluated. Influence of treatment modality, clinical conditions, and analgosedation were analyzed.ResultsData of 13 patients were analyzed. 31P-MRS showed significant changes in cerebral energy metabolism after aSAH in all cerebrovascular territories. Both PCr/ATP and PCr/Pi ratio were notably increased (P < 0.001). Also, Pi/ATP was significantly decreased in all cerebrovascular territories (P = 0.014). PME/PDE ratio was overall significant decreased (P < 0.001).Conclusion31P-MRS is a promising non-invasive imaging tool for the assessment of changes in energy metabolism after aSAH. It allows a detailed insight into EBI and seems to harbor a high potential for clinical practice. Acute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall neurological outcome. However, direct detection of these alterations is limited. Phosphorous magnetic resonance spectroscopy (31P-MRS) is a molecular-based advanced neuroimaging technique allowing measurements of pathophysiological processes and tissue metabolism based on various phosphorous compound metabolites. This method may provide objective assessment of both primary and secondary changes.BackgroundAcute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall neurological outcome. However, direct detection of these alterations is limited. Phosphorous magnetic resonance spectroscopy (31P-MRS) is a molecular-based advanced neuroimaging technique allowing measurements of pathophysiological processes and tissue metabolism based on various phosphorous compound metabolites. This method may provide objective assessment of both primary and secondary changes.The aim of this pilot study was to evaluate the feasibility and the diagnostic potential of early 31P-MRS in aSAH.ObjectiveThe aim of this pilot study was to evaluate the feasibility and the diagnostic potential of early 31P-MRS in aSAH.Patients with aSAH treated for ruptured aneurysms between July 2016 and October 2017 were prospectively included in the study. 3-Tesla-MRI including 31P-MRS was performed within the first 72 h after hemorrhage. Data of the vascular territories of the anterior, middle, and posterior cerebral arteries (ACA, MCA, PCA) and the basal ganglia were separately analyzed and compared with data of a healthy age- and sex-matched control group. Phosphorous compound metabolites were quantified, and ratios of these metabolites were further evaluated. Influence of treatment modality, clinical conditions, and analgosedation were analyzed.MethodsPatients with aSAH treated for ruptured aneurysms between July 2016 and October 2017 were prospectively included in the study. 3-Tesla-MRI including 31P-MRS was performed within the first 72 h after hemorrhage. Data of the vascular territories of the anterior, middle, and posterior cerebral arteries (ACA, MCA, PCA) and the basal ganglia were separately analyzed and compared with data of a healthy age- and sex-matched control group. Phosphorous compound metabolites were quantified, and ratios of these metabolites were further evaluated. Influence of treatment modality, clinical conditions, and analgosedation were analyzed.Data of 13 patients were analyzed. 31P-MRS showed significant changes in cerebral energy metabolism after aSAH in all cerebrovascular territories. Both PCr/ATP and PCr/Pi ratio were notably increased (P < 0.001). Also, Pi/ATP was significantly decreased in all cerebrovascular territories (P = 0.014). PME/PDE ratio was overall significant decreased (P < 0.001).ResultsData of 13 patients were analyzed. 31P-MRS showed significant changes in cerebral energy metabolism after aSAH in all cerebrovascular territories. Both PCr/ATP and PCr/Pi ratio were notably increased (P < 0.001). Also, Pi/ATP was significantly decreased in all cerebrovascular territories (P = 0.014). PME/PDE ratio was overall significant decreased (P < 0.001).31P-MRS is a promising non-invasive imaging tool for the assessment of changes in energy metabolism after aSAH. It allows a detailed insight into EBI and seems to harbor a high potential for clinical practice.Conclusion31P-MRS is a promising non-invasive imaging tool for the assessment of changes in energy metabolism after aSAH. It allows a detailed insight into EBI and seems to harbor a high potential for clinical practice. |
| Author | Luger, Markus Steiger, Ruth Grams, Astrid Ellen Gizewski, Elke Ruth Rietzler, Andreas Ho, Wing Mann Treichl, Stephanie Alice Thomé, Claudius Petr, Ondra |
| AuthorAffiliation | 3 Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck , Innsbruck , Austria 1 Department of Neurosurgery, Medical University of Innsbruck , Innsbruck , Austria 4 Neuroimaging Research Core Facility, Medical University of Innsbruck , Innsbruck , Austria 2 Department of Neuroradiology, Medical University of Innsbruck , Innsbruck , Austria |
| AuthorAffiliation_xml | – name: 3 Department of Anesthesiology and Critical Care Medicine, Medical University of Innsbruck , Innsbruck , Austria – name: 2 Department of Neuroradiology, Medical University of Innsbruck , Innsbruck , Austria – name: 1 Department of Neurosurgery, Medical University of Innsbruck , Innsbruck , Austria – name: 4 Neuroimaging Research Core Facility, Medical University of Innsbruck , Innsbruck , Austria |
| Author_xml | – sequence: 1 givenname: Stephanie Alice surname: Treichl fullname: Treichl, Stephanie Alice – sequence: 2 givenname: Wing Mann surname: Ho fullname: Ho, Wing Mann – sequence: 3 givenname: Ruth surname: Steiger fullname: Steiger, Ruth – sequence: 4 givenname: Astrid Ellen surname: Grams fullname: Grams, Astrid Ellen – sequence: 5 givenname: Andreas surname: Rietzler fullname: Rietzler, Andreas – sequence: 6 givenname: Markus surname: Luger fullname: Luger, Markus – sequence: 7 givenname: Elke Ruth surname: Gizewski fullname: Gizewski, Elke Ruth – sequence: 8 givenname: Claudius surname: Thomé fullname: Thomé, Claudius – sequence: 9 givenname: Ondra surname: Petr fullname: Petr, Ondra |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35295831$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1v1DAQjVARLaU_gAvykUsWfyROzAFpWS10pVasWDhbdjzZ9SqxFzuplF_BX8bbLVXLAV88nnnvzWj8XmdnzjvIsrcEzxirxYfWwRhmFFM6qxkpWfUiuyCcFzmlojx7Ep9nVzHucTpMCMbZq-yclSmfWBfZ7wUE0EF1aOkgbCe0GdQwRqScQfNuSEWDbmFQ2nc29sg6tFShm9DnoFK8cvsxTGjeJiCaHweaYp-0NqNWQTU7561B19D7EHZqCx_RHK2DjwdoBnsHiJF1fvt9g9a280PqPJrpTfayVV2Eq4f7Mvv5ZfljcZ3ffPu6Wsxv8qbgZMhZC6WmRBsCFdZMKJ5eBrg2qqqVVjWYltYFVwpDaagpaUlwWyloaZVQjF1mq5Ou8WovD8H2KkzSKyvvEz5spQqDbTqQFeOlwQ1pcFEUmghthMA18JbUbVXRKml9OmkdRt2DacANaaHPRJ9XnN3Jrb-TtSBCCJIE3j8IBP9rhDjI3sYGuk458GOUlBeYUY7xsde7p70em_z90QQgJ0CTFh0DtI8QguXROPLeOPJoHHkyTuJU_3Aam2xg_XFc2_2H-QfRsctY |
| CitedBy_id | crossref_primary_10_3389_fneur_2023_1173285 crossref_primary_10_3390_ijms23094910 crossref_primary_10_1007_s11910_024_01396_1 crossref_primary_10_3390_diagnostics14080841 crossref_primary_10_3390_ijms25126597 |
| Cites_doi | 10.1016/s0021-9258(19)35418-3 10.1007/s12975-013-0257-2 10.1089/neu.2009.0924 10.3171/2017.8.focus17450 10.1155/2018/7806395 10.1089/neu.2014.3505 10.21037/qims.2017.11.03 10.3389/fneur.2017.00426 10.1097/mcc.0b013e32835132a5 10.1176/jnp.10.2.133 10.1006/jmre.1997.1244 10.1007/s12028-013-9884-4 10.3171/jns.1993.78.1.0112 10.1002/1099-1492(200005)13:3<154::aid-nbm620>3.0.co;2-w 10.1007/s12028-020-01042-x 10.1002/mrm.20312 10.1007/s10143-017-0827-y 10.1042/bj2810021 10.1016/0006-8993(91)90755-k 10.1179/016164106x115008 10.3171/jns.1988.68.1.0129 10.1177/0271678x18799176 10.1016/s0735-1097(02)02160-5 10.1016/j.pscychresns.2013.06.011 10.1089/neu.1988.5.315 10.1159/000017471 10.1097/00004647-199701000-00007 10.1016/0741-8329(94)00072-7 10.1038/s41598-018-29255-3 10.1186/cc11513 10.1089/08977150151070838 10.3389/fneur.2020.00219 10.1089/neu.2021.0143 10.1111/bdi.12339 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Treichl, Ho, Steiger, Grams, Rietzler, Luger, Gizewski, Thomé and Petr. Copyright © 2022 Treichl, Ho, Steiger, Grams, Rietzler, Luger, Gizewski, Thomé and Petr. 2022 Treichl, Ho, Steiger, Grams, Rietzler, Luger, Gizewski, Thomé and Petr |
| Copyright_xml | – notice: Copyright © 2022 Treichl, Ho, Steiger, Grams, Rietzler, Luger, Gizewski, Thomé and Petr. – notice: Copyright © 2022 Treichl, Ho, Steiger, Grams, Rietzler, Luger, Gizewski, Thomé and Petr. 2022 Treichl, Ho, Steiger, Grams, Rietzler, Luger, Gizewski, Thomé and Petr |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fneur.2022.831537 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1664-2295 |
| ExternalDocumentID | oai_doaj_org_article_7365d0c1c0444b19bd9908e6f18f7727 PMC8919991 35295831 10_3389_fneur_2022_831537 |
| Genre | Journal Article |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK E3Z EMOBN F5P GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 P2P PGMZT RNS RPM ACXDI IAO IEA IHR IHW IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c461t-3fe5b21bd1e70b39a6b21de6bda78aba8edf2846aa0e5d2d52510f7aef27e6b33 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 5 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000771933600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1664-2295 |
| IngestDate | Fri Oct 03 12:46:56 EDT 2025 Thu Aug 21 18:16:45 EDT 2025 Fri Sep 05 06:21:08 EDT 2025 Thu Jan 02 22:55:11 EST 2025 Sat Nov 29 06:39:34 EST 2025 Tue Nov 18 21:00:42 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | brain metabolism energy status 31-P-MR-spectroscopy subarachnoid hemorrhage early brain injury |
| Language | English |
| License | Copyright © 2022 Treichl, Ho, Steiger, Grams, Rietzler, Luger, Gizewski, Thomé and Petr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c461t-3fe5b21bd1e70b39a6b21de6bda78aba8edf2846aa0e5d2d52510f7aef27e6b33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Deqiang Qiu, Emory University, United States Reviewed by: Eric Peter Thelin, Karolinska Institutet (KI), Sweden; Eugene Golanov, Houston Methodist Hospital, United States This article was submitted to Applied Neuroimaging, a section of the journal Frontiers in Neurology |
| OpenAccessLink | https://doaj.org/article/7365d0c1c0444b19bd9908e6f18f7727 |
| PMID | 35295831 |
| PQID | 2640326007 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7365d0c1c0444b19bd9908e6f18f7727 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8919991 proquest_miscellaneous_2640326007 pubmed_primary_35295831 crossref_primary_10_3389_fneur_2022_831537 crossref_citationtrail_10_3389_fneur_2022_831537 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-02-28 |
| PublicationDateYYYYMMDD | 2022-02-28 |
| PublicationDate_xml | – month: 02 year: 2022 text: 2022-02-28 day: 28 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in neurology |
| PublicationTitleAlternate | Front Neurol |
| PublicationYear | 2022 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Stocchetti (B4) 2013; 17 Domingo (B10) 2000; 13 Beer (B15) 2002; 40 Yoshino (B22) 1991; 561 Altura (B9) 1995; 12 Pinggera (B20) 2021; 38 Vanhamme (B13) 1997; 129 Garnett (B18) 2001; 18 Stovell (B21) 2018; 8 Kato (B28) 1998; 10 VINK (B29) 1988; 5 Stovell (B34) 2017; 8 Oddo (B5) 2012; 18 Pinggera (B19) 2020; 34 de Lima Oliveira (B6) 2014; 21 Vink (B11) 1988; 263 Shi (B27) 2015; 17 Ishige (B31) 1988; 68 Ostrowski (B3) 2013; 28 Weber-Fahr (B26) 2013; 214 Pinggera (B23) 2020; 11 Tavakoli (B7) 2017; 43 Stovell (B33) 2020; 40 Schubert (B24) 2009; 26 Handa (B12) 1993; 78 Maudsley (B32) 2015; 32 Steiger (B25) 2018; 2018 Vink (B30) 1997; 17 Liu (B14) 2017; 7 van Lieshout (B1) 2018; 41 Kemp (B8) 2000; 22 Wallimann (B17) 1992; 281 Fujii (B2) 2013; 4 Albers (B16) 2005; 53 |
| References_xml | – volume: 263 start-page: 757 year: 1988 ident: B11 article-title: Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma publication-title: J Biol Chem. doi: 10.1016/s0021-9258(19)35418-3 – volume: 4 start-page: 432 year: 2013 ident: B2 article-title: Early brain injury, an evolving frontier in subarachnoid hemorrhage research publication-title: Transl Stroke Res. doi: 10.1007/s12975-013-0257-2 – volume: 26 start-page: 2225 year: 2009 ident: B24 article-title: Acute hypoperfusion immediately after subarachnoid hemorrhage: a xenon contrast-enhanced CT study publication-title: J Neurotraum. doi: 10.1089/neu.2009.0924 – volume: 43 start-page: E6 year: 2017 ident: B7 article-title: Complications of invasive intracranial pressure monitoring devices in neurocritical care publication-title: Neurosurg Focus. doi: 10.3171/2017.8.focus17450 – volume: 2018 start-page: 7806395 year: 2018 ident: B25 article-title: Cerebral phosphorus magnetic resonance spectroscopy in a patient with giant cell arteritis and endovascular therapy publication-title: Case Rep Radiol. doi: 10.1155/2018/7806395 – volume: 32 start-page: 1056 year: 2015 ident: B32 article-title: Distributions of magnetic resonance diffusion and spectroscopy measures with traumatic brain injury publication-title: J Neurotraum. doi: 10.1089/neu.2014.3505 – volume: 7 start-page: 707 year: 2017 ident: B14 article-title: Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review publication-title: Quant Imaging Med Surg. doi: 10.21037/qims.2017.11.03 – volume: 8 start-page: 426 year: 2017 ident: B34 article-title: Assessing metabolism and injury in acute human traumatic brain injury with magnetic resonance spectroscopy: current and future applications publication-title: Front Neurol. doi: 10.3389/fneur.2017.00426 – volume: 18 start-page: 111 year: 2012 ident: B5 article-title: Brain multimodality monitoring publication-title: Curr Opin Crit Care. doi: 10.1097/mcc.0b013e32835132a5 – volume: 10 start-page: 133 year: 1998 ident: B28 article-title: Magnetic resonance spectroscopy in affective disorders publication-title: J Neuropsychiatry Clin Neurosci. doi: 10.1176/jnp.10.2.133 – volume: 129 start-page: 35 year: 1997 ident: B13 article-title: Improved method for accurate and efficient quantification of MRS data with use of prior knowledge publication-title: J Magn Reson. doi: 10.1006/jmre.1997.1244 – volume: 21 start-page: 152 year: 2014 ident: B6 article-title: Cerebral microdialysis in traumatic brain injury and subarachnoid hemorrhage: state of the art publication-title: Neurocrit Care. doi: 10.1007/s12028-013-9884-4 – volume: 78 start-page: 112 year: 1993 ident: B12 article-title: Effect of systemic hypotension on cerebral energy metabolism during chronic cerebral vasospasm in primates publication-title: J Neurosurg. doi: 10.3171/jns.1993.78.1.0112 – volume: 13 start-page: 154 year: 2000 ident: B10 article-title: Diffusion weighted imaging and magnetic resonance spectroscopy in a low flow ischaemia model due to endothelin induced vasospasm publication-title: NMR Biomed. doi: 10.1002/1099-1492(200005)13:3<154::aid-nbm620>3.0.co;2-w – volume: 34 start-page: 432 year: 2020 ident: B19 article-title: Cerebral energy status and altered metabolism in early severe TBI: first results of a prospective 31P-MRS feasibility study publication-title: Neurocrit Care. doi: 10.1007/s12028-020-01042-x – volume: 53 start-page: 22 year: 2005 ident: B16 article-title: Proton-decoupled 31P MRS in untreated pediatric brain tumors publication-title: Magnet Reson Med. doi: 10.1002/mrm.20312 – volume: 41 start-page: 917 year: 2018 ident: B1 article-title: An introduction to the pathophysiology of aneurysmal subarachnoid hemorrhage publication-title: Neurosurg Rev. doi: 10.1007/s10143-017-0827-y – volume: 281 start-page: 21 year: 1992 ident: B17 article-title: Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasis publication-title: Biochem J. doi: 10.1042/bj2810021 – volume: 561 start-page: 106 year: 1991 ident: B22 article-title: Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state publication-title: Brain Res. doi: 10.1016/0006-8993(91)90755-k – volume: 28 start-page: 399 year: 2013 ident: B3 article-title: Molecular mechanisms of early brain injury after subarachnoid hemorrhage publication-title: Neurol Res. doi: 10.1179/016164106x115008 – volume: 68 start-page: 129 year: 1988 ident: B31 article-title: The effects of hypovolemic hypotension on high-energy phosphate metabolism of traumatized brain in rats publication-title: J Neurosurg. doi: 10.3171/jns.1988.68.1.0129 – volume: 40 start-page: 67 year: 2020 ident: B33 article-title: Phosphorus spectroscopy in acute TBI demonstrates metabolic changes that relate to outcome in the presence of normal structural MRI publication-title: J Cereb Blood Flow Metab. doi: 10.1177/0271678x18799176 – volume: 40 start-page: 1267 year: 2002 ident: B15 article-title: Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy publication-title: J Am Coll Cardiol. doi: 10.1016/s0735-1097(02)02160-5 – volume: 214 start-page: 365 year: 2013 ident: B26 article-title: Altered phospholipid metabolism in schizophrenia: a phosphorus 31 nuclear magnetic resonance spectroscopy study publication-title: Psychiatry Res Neuroimaging. doi: 10.1016/j.pscychresns.2013.06.011 – volume: 5 start-page: 315 year: 1988 ident: B29 article-title: Changes in cellular bioenergetic state following graded traumatic brain injury in rats: determination by phosphorus 31 magnetic resonance spectroscopy publication-title: J Neurotraum. doi: 10.1089/neu.1988.5.315 – volume: 22 start-page: 418 year: 2000 ident: B8 article-title: Non-invasive methods for studying brain energy metabolism: what they show and what it means publication-title: Dev Neurosci Basel. doi: 10.1159/000017471 – volume: 17 start-page: 50 year: 1997 ident: B30 article-title: McIntosh* TK. Blood glucose concentration does not affect outcome in brain trauma publication-title: J Cereb Blood Flow Metabolism. doi: 10.1097/00004647-199701000-00007 – volume: 12 start-page: 131 year: 1995 ident: B9 article-title: Role of brain [Mg2+]i in alcohol-induced hemorrhagic stroke in a rat model: a 31P-NMR in vivo study publication-title: Alcohol. doi: 10.1016/0741-8329(94)00072-7 – volume: 8 start-page: 11140 year: 2018 ident: B21 article-title: The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury publication-title: Sci Rep. doi: 10.1038/s41598-018-29255-3 – volume: 17 start-page: 201 year: 2013 ident: B4 article-title: Clinical review: neuromonitoring - an update publication-title: Crit Care. doi: 10.1186/cc11513 – volume: 18 start-page: 231 year: 2001 ident: B18 article-title: Altered cellular metabolism following traumatic brain injury: a magnetic resonance spectroscopy study publication-title: J Neurotraum. doi: 10.1089/08977150151070838 – volume: 11 start-page: 219 year: 2020 ident: B23 article-title: Safety of early MRI examinations in severe TBI: a test battery for proper patient selection publication-title: Front Neurol. doi: 10.3389/fneur.2020.00219 – volume: 38 start-page: 2822 year: 2021 ident: B20 article-title: Repeated 31P-magnetic resonance spectroscopy in severe traumatic brain injury: insights into cerebral energy status and altered metabolism publication-title: J Neurotraum. doi: 10.1089/neu.2021.0143 – volume: 17 start-page: 743 year: 2015 ident: B27 article-title: Decreased brain PME/PDE ratio in bipolar disorder: a preliminary 31P magnetic resonance spectroscopy study publication-title: Bipolar Disord. doi: 10.1111/bdi.12339 |
| SSID | ssj0000399363 |
| Score | 2.289498 |
| Snippet | Acute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for overall... BackgroundAcute changes of cerebral energy metabolism in early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) may play a crucial role for... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 831537 |
| SubjectTerms | 31-P-MR-spectroscopy brain metabolism early brain injury energy status Neurology subarachnoid hemorrhage |
| Title | Cerebral Energy Status and Altered Metabolism in Early Brain Injury After Aneurysmal Subarachnoid Hemorrhage: A Prospective 31P-MRS Pilot Study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35295831 https://www.proquest.com/docview/2640326007 https://pubmed.ncbi.nlm.nih.gov/PMC8919991 https://doaj.org/article/7365d0c1c0444b19bd9908e6f18f7727 |
| Volume | 13 |
| WOSCitedRecordID | wos000771933600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1664-2295 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000399363 issn: 1664-2295 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1664-2295 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000399363 issn: 1664-2295 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Li5xAEG6SJYRcQt4xj6UDOQXMqj3ampu7zLKBzDLkxdyk265mXGY1qLOwl_0L-cupap1hJoTkkougttpWVdeD6vqKsbcAErSMMDrJNGCAooWvbDTxtUgE2CDNtKtK-_5Jnp-ni0U232n1RXvCBnjggXBHUiSxCcqwJGAzjW80qD9TSGyYWvQMXR15ILOdYMrpYLK7iRjSmBiFZUeW8CExHoyi96nAZS73DJHD6_-Tk_n7Xskd43P6gN0fvUaeD7N9yG5B_YjdnY158cfs5wm0lAFe8amr5ePkQ647rmrDc8qHg-Ez6JHhq6q75FXNHbAxP6YGEfxjfYGU5Tm1C-c5_cF1d4nvQqVCaM7LuqkMP6Mtue0S1c8HnvN522xqNLkI5_7s8xc-r1ZNz2lj4vUT9u10-vXkzB9bLfjlJAl7X1iIdRRqE4JEfmUqwTMDiTZKpkqrFIxFQ5YoFUBsIhOjWxRYqcBGEkcJ8ZQd1E0NzxlXsQ3KANA6GgzerFGBTTLkemTQHMMEPBZs6F6UIw45tcNYFRiPEKsKx6qCWFUMrPLYu-0jPwYQjr8NPiZmbgcSfra7gFJVjFJV_EuqPPZmIwoFrjdKoqgamnVXoAMZCIfq77Fng2hsPyUoa4qz8JjcE5q9uezfqaulw_ROM8KDCF_8j8m_ZPeIHkPh_St20LdreM3ulFd91bWH7LZcpIduueBxdjP9BSQ0HOk |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cerebral+Energy+Status+and+Altered+Metabolism+in+Early+Brain+Injury+After+Aneurysmal+Subarachnoid+Hemorrhage%3A+A+Prospective+31P-MRS+Pilot+Study&rft.jtitle=Frontiers+in+neurology&rft.au=Treichl%2C+Stephanie+Alice&rft.au=Ho%2C+Wing+Mann&rft.au=Steiger%2C+Ruth&rft.au=Grams%2C+Astrid+Ellen&rft.date=2022-02-28&rft.pub=Frontiers+Media+S.A&rft.eissn=1664-2295&rft.volume=13&rft_id=info:doi/10.3389%2Ffneur.2022.831537&rft_id=info%3Apmid%2F35295831&rft.externalDocID=PMC8919991 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2295&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2295&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2295&client=summon |