Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts

Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years:...

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Veröffentlicht in:Metabolites Jg. 11; H. 9; S. 614
Hauptverfasser: Quek, Debra Q. Y., He, Feng, Sultana, Rehena, Banu, Riswana, Chee, Miao Li, Nusinovici, Simon, Thakur, Sahil, Qian, Chaoxu, Cheng, Ching-Yu, Wong, Tien Y., Sabanayagam, Charumathi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 09.09.2021
MDPI
Schlagworte:
Amino acids
Blood pressure
Cholesterol
Citric acid
Creatinine
Cross-sectional studies
cross-sectional study
Diabetes
Diabetes mellitus
Diabetic retinopathy
Esters
Ethanolamine
Glycolysis
Hypoxanthine
Lipid metabolism
Lipids
Lipoproteins
Mass spectrometry
Metabolic disorders
Metabolism
Metabolites
Microvasculature
Minority & ethnic groups
NMR
Nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
Plasma
Population studies
Regression analysis
Retinopathy
Risk factors
Scientific imaging
serum/plasma metabolites
Spectroscopy
Tyrosine
urinary metabolites
Urine
Singapore
ISSN:2218-1989, 2218-1989
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Zusammenfassung:Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years: Chinese, 592; Malays, 1052; Indians, 1320) was performed. A panel of 228 serum/plasma metabolites and 54 urinary metabolites were quantified using nuclear magnetic resonance (NMR) spectroscopy. Main outcomes were defined as any DR, moderate/above DR, and vision-threatening DR assessed from retinal photographs. The relationship between metabolites and DR outcomes was assessed using multivariate logistic regression models, and metabolites significant after Bonferroni correction were meta-analyzed. Among serum/plasma metabolites, lower levels of tyrosine and cholesterol esters to total lipids ratio in IDL and higher levels of creatinine were positively associated with all three outcomes of DR (all p < 0.005). Among urinary metabolites, lower levels of citrate, ethanolamine, formate, and hypoxanthine were positively associated with all three DR outcomes (all p < 0.005). Higher levels of serum/plasma 3-hydroxybutyrate and lower levels of urinary 3-hydroxyisobutyrate were associated with VTDR. Comprehensive metabolic profiling in three large Asian cohorts with DR demonstrated alterations in serum/plasma and urinary metabolites mostly related to amino acids, lipoprotein subclasses, kidney function, and glycolysis.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2218-1989
2218-1989
DOI:10.3390/metabo11090614