Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration

Prostate cancer is a significant global health issue, and limitations to current patient management pathways often result in overtreatment or undertreatment. New ways to stratify patients are urgently needed. We conducted a feasibility study of such novel assessments, looking for associations betwee...

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Vydáno v:	The Journal of molecular diagnostics : JMD Ročník 22; číslo 5; s. 652
Hlavní autoři:	Rao, Srinivasa R, Alham, Nasullah K, Upton, Elysia, McIntyre, Stacey, Bryant, Richard J, Cerundolo, Lucia, Bowes, Emma, Jones, Stephanie, Browne, Molly, Mills, Ian, Lamb, Alastair, Tomlinson, Ian, Wedge, David, Browning, Lisa, Sirinukunwattana, Korsuk, Palles, Claire, Hamdy, Freddie C, Rittscher, Jens, Verrill, Clare
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.05.2020
Témata:	Biomarkers, Tumor Class Ia Phosphatidylinositol 3-Kinase - genetics DNA Helicases - genetics DNA Mismatch Repair DNA-Binding Proteins - genetics Gene Expression Profiling Gene Expression Regulation, Neoplastic High-Throughput Nucleotide Sequencing Humans Immunohistochemistry INDEL Mutation Lymphocytes - immunology Lymphocytes - metabolism Lymphocytes - pathology Male Oncogene Proteins, Fusion - genetics Polymorphism, Single Nucleotide Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Sequence Analysis, RNA Serine Endopeptidases - genetics Transcriptional Regulator ERG - genetics
ISSN:	1943-7811, 1943-7811
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