Comprehensive 4D robustness evaluation for pencil beam scanned proton plans

Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evalua...

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Bibliographic Details
Published in:Radiotherapy and oncology Vol. 136; pp. 185 - 189
Main Authors: Ribeiro, Cássia O., Meijers, Arturs, Korevaar, Erik W., Muijs, Christina T., Both, Stefan, Langendijk, Johannes A., Knopf, Antje
Format: Journal Article
Language:English
Published: Ireland Elsevier B.V 01.07.2019
Subjects:
4D robustness evaluation
Esophageal Neoplasms - diagnostic imaging
Esophageal Neoplasms - radiotherapy
Four-Dimensional Computed Tomography - methods
Humans
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - radiotherapy
Moving targets
Oesophagus cancer
Pencil beam scanned proton therapy
Proton Therapy - methods
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Voxel-wise worst-case dose
Moving targets
Pencil beam scanned proton therapy
4D robustness evaluation
Voxel-wise worst-case dose
Lung cancer
Oesophagus cancer
ISSN:0167-8140, 1879-0887, 1879-0887
Online Access:Get full text
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Summary:Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select and apply motion mitigation techniques.
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ISSN:0167-8140
1879-0887
1879-0887
DOI:10.1016/j.radonc.2019.03.037