Comprehensive 4D robustness evaluation for pencil beam scanned proton plans

Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evalua...

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Vydané v:	Radiotherapy and oncology Ročník 136; s. 185 - 189
Hlavní autori:	Ribeiro, Cássia O., Meijers, Arturs, Korevaar, Erik W., Muijs, Christina T., Both, Stefan, Langendijk, Johannes A., Knopf, Antje
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Ireland Elsevier B.V 01.07.2019
Predmet:	4D robustness evaluation Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - radiotherapy Four-Dimensional Computed Tomography - methods Humans Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - radiotherapy Moving targets Oesophagus cancer Pencil beam scanned proton therapy Proton Therapy - methods Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Voxel-wise worst-case dose Moving targets Pencil beam scanned proton therapy 4D robustness evaluation Voxel-wise worst-case dose Lung cancer Oesophagus cancer
ISSN:	0167-8140, 1879-0887, 1879-0887
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Abstract	Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select and apply motion mitigation techniques.
AbstractList	Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select and apply motion mitigation techniques. Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select and apply motion mitigation techniques.Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties caused by motion. We developed a method, the 4D robustness evaluation method (4DREM), to realistically and efficiently assess all possible events impacting PBS-PT treatments in the thorax. Using the 4DREM in large cohorts of lung and oesophageal cancer patients, it will become possible to illustrate, in clinical practice, how to trigger robustness settings for plan optimisation and to select and apply motion mitigation techniques.
Author	Korevaar, Erik W. Langendijk, Johannes A. Muijs, Christina T. Knopf, Antje Ribeiro, Cássia O. Both, Stefan Meijers, Arturs
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Keywords	Moving targets Pencil beam scanned proton therapy 4D robustness evaluation Voxel-wise worst-case dose Lung cancer Oesophagus cancer
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Snippet	Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they...
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SubjectTerms	4D robustness evaluation Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - radiotherapy Four-Dimensional Computed Tomography - methods Humans Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - radiotherapy Moving targets Oesophagus cancer Pencil beam scanned proton therapy Proton Therapy - methods Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Voxel-wise worst-case dose
Title	Comprehensive 4D robustness evaluation for pencil beam scanned proton plans
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