Osmolar gap with Minimal Acidosis in Combined Methanol and Methyl Ethyl Ketone Ingestion

Methyl ethyl ketone is a common solvent but data on overdose in humans are scarce. We report a case of co-ingestion of methyl ethyl ketone together with methanol associated with a hyperosmolar coma without anion gap metabolic acidosis. Blood levels of methyl ethyl ketone and its metabolite, 2-butano...

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Vydané v:	Journal of toxicology. Clinical toxicology Ročník 32; číslo 1; s. 79 - 84
Hlavní autori:	Price, E. A., D'alessandro, A., Kearney, T., Olson, K. R., Blanc, P. D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Monticello, NY Taylor & Francis 01.01.1994 Dekker
Predmet:	Acidosis - chemically induced Administration, Oral Adult Biological and medical sciences Butanones - blood Butanones - poisoning Chemical and industrial products toxicology. Toxic occupational diseases Drug Interactions human Humans Male Medical sciences methanol Methanol - blood Methanol - poisoning methyl ethyl ketone Osmolar Concentration poisoning Poisoning - physiopathology Solvents Toxicology Coma Human Nervous system diseases Toxicity Consciousness impairment Acid base balance disorder Ketone Toxic association Hyperosmolarity Organic solvent Metabolic disorder Poisoning Neurological disorder Methanol
ISSN:	0731-3810
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Shrnutí:	Methyl ethyl ketone is a common solvent but data on overdose in humans are scarce. We report a case of co-ingestion of methyl ethyl ketone together with methanol associated with a hyperosmolar coma without anion gap metabolic acidosis. Blood levels of methyl ethyl ketone and its metabolite, 2-butanol, indicated that this solvent did contribute approximately 20 mosm/L to an observed osmolar gap of 99 mosm/L. At the levels detected, methyl ethyl ketone may have inhibited methanol metabolism, contributing to the low serum formate (1.3 mmol/L) and normal anion gap despite a blood methanol of 67 mmol/L.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0731-3810
DOI:	10.3109/15563659409000434