Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development

Mutations in the transcription factor TBX20 are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by E9.5. As Tbx20 is expressed in multiple cell lineages required for myocardial development, including pharyngeal endode...

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Veröffentlicht in:	Circulation research Jg. 123; H. 4; S. 428
Hauptverfasser:	Boogerd, Cornelis J, Zhu, Xiaoming, Aneas, Ivy, Sakabe, Noboru J, Zhang, Lunfeng, Sobreira, Debora R, Montefiori, Lindsey E, Bogomolovas, Julius, Joslin, Amelia C, Zhou, Bin, Chen, Ju, Nobrega, Marcelo, Evans, Sylvia M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.08.2018
Schlagworte:	cardiomyocyte differentiation congenital heart disease heart development transcriptional regulation chamber specification
ISSN:	1524-4571, 1524-4571
Online-Zugang:	Weitere Angaben
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