Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial

Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one‐stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups....

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Vydané v:	Journal of clinical periodontology Ročník 42; číslo 2; s. 160 - 168
Hlavní autori:	Ardila, Carlos Martín, Martelo-Cadavid, Juan Felipe, Boderth-Acosta, Gina, Ariza-Garcés, Astrid Adriana, Guzmán, Isabel C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Blackwell Publishing Ltd 01.02.2015
Predmet:	Adult Aggregatibacter actinomycetemcomitans - drug effects Aggregatibacter actinomycetemcomitans - isolation & purification Aggressive Periodontitis - drug therapy Aggressive Periodontitis - microbiology Aggressive Periodontitis - therapy Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Bacterial Load - drug effects Bacteroides - drug effects Bacteroides - isolation & purification Clinical outcomes Combined Modality Therapy Dental Plaque - microbiology Dental Scaling - methods Dentistry Drug therapy Female Fluoroquinolones - administration & dosage Fluoroquinolones - therapeutic use Follow-Up Studies generalized aggressive periodontitis Gingival Hemorrhage - drug therapy Gingival Hemorrhage - therapy Gum disease Humans Male Microbiology moxifloxacin Periodontal Attachment Loss - drug therapy Periodontal Attachment Loss - therapy Periodontal Pocket - drug therapy Periodontal Pocket - microbiology Periodontal Pocket - therapy periodontitis/therapy periodontitis/therapy, randomized‐controlled clinical trial Placebos Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - isolation & purification randomized-controlled clinical trial Root Planing - methods Treatment Outcome Young Adult microbiology periodontitis/therapy, randomized-controlled clinical trial generalized aggressive periodontitis moxifloxacin
ISSN:	0303-6979, 1600-051X, 1600-051X
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Shrnutí:	Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one‐stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi‐nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one‐stage full‐mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment.
Bibliografia:	School of Dentistry of the Universidad de Antioquia, Medellín, Colombia - No. NCT02125812 ArticleID:JCPE12345 ark:/67375/WNG-RKWTRBZV-0 istex:5B95F2A19E2E96572A904DF7C57356D3522CC637 The authors declare that they have no conflict of interest in relation to this investigation. The School of Dentistry of the Universidad de Antioquia, Medellín, Colombia financed the study. Conflict of interest and source of funding statement ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0303-6979 1600-051X 1600-051X
DOI:	10.1111/jcpe.12345