Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one‐stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups....
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| Vydáno v: | Journal of clinical periodontology Ročník 42; číslo 2; s. 160 - 168 |
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| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Blackwell Publishing Ltd
01.02.2015
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| ISSN: | 0303-6979, 1600-051X, 1600-051X |
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| Abstract | Aim
The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one‐stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP).
Materials and Methods
Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi‐nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria.
Results
Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group.
Conclusions
The results from this study suggest that moxifloxacin as and adjunct to one‐stage full‐mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. |
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| AbstractList | The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP).
Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically administered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria.
Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥ 6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group.
The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP).AIMThe aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP).Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically administered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria.MATERIALS AND METHODSForty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically administered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria.Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥ 6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group.RESULTSBoth groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥ 6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group.The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment.CONCLUSIONSThe results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one‐stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi‐nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one‐stage full‐mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. |
| Author | Ariza-Garcés, Astrid Adriana Guzmán, Isabel C. Martelo-Cadavid, Juan Felipe Ardila, Carlos Martín Boderth-Acosta, Gina |
| Author_xml | – sequence: 1 givenname: Carlos Martín surname: Ardila fullname: Ardila, Carlos Martín email: martinardila@gmail.commartin.ardila@udea.edu.co organization: Stomatology Biomedical Group, Universidad de Antioquia (U de A), Medellín, Colombia – sequence: 2 givenname: Juan Felipe surname: Martelo-Cadavid fullname: Martelo-Cadavid, Juan Felipe organization: Stomatology Biomedical Group, Universidad de Antioquia (U de A), Medellín, Colombia – sequence: 3 givenname: Gina surname: Boderth-Acosta fullname: Boderth-Acosta, Gina organization: Dentist, Universidad Cooperativa de Colombia, Medellín, Colombia – sequence: 4 givenname: Astrid Adriana surname: Ariza-Garcés fullname: Ariza-Garcés, Astrid Adriana organization: Stomatology Biomedical Group, Universidad de Antioquia (U de A), Medellín, Colombia – sequence: 5 givenname: Isabel C. surname: Guzmán fullname: Guzmán, Isabel C. organization: Stomatology Biomedical Group, Universidad de Antioquia (U de A), Medellín, Colombia |
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| Keywords | microbiology periodontitis/therapy, randomized-controlled clinical trial generalized aggressive periodontitis moxifloxacin |
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(2005) Periodontal pathogens: a quantitative comparison of anaerobic culture and real-time PCR. FEMS Immunol Med Microbiol 45, 191-199. Teughels, W., Dhondt, R., Dekeyser, C. & Quirynen, M. (2014) Treatment of aggressive periodontitis. Periodontology 2000 65, 107-133. Armitage, G. C. (1999) Development of a classification and conditions. Annals of Periodontology 4, 166. Frothingham, R. (2001) Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin. Pharmacotherapy 21, 1468-1472. Herrera, D., Contreras, A., Gamonal, J., Oteo, A., Jaramillo, A., Silva, N., Sanz, M., Botero, J. E. & León, R. (2008b) Subgingival microbial profiles in chronic periodontitis patients from Chile, Colombia and Spain. Journal of Clinical Periodontology 35, 106-113. Aimetti, M., Romano, F., Guzzi, N. & Carnevale, G. (2012) Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo- controlled trial. Journal of Clinical Periodontology 39, 284-294. Cachovan, G., Nergiz, I., Thuss, U., Siefert, H. M., Sobottka, I., Oral, O., Platzer, U. & Dogan-Onur, O. (2009) Penetration of moxifloxacin into rat mandibular bone and soft tissue. Acta Odontologica Scandinavica 67, 182-186. Fujise, O., Hamachi, T., Inoue, K., Miura, M. & Maeda, K. (2002) Microbiological markers for prediction and assessment of treatment outcome following non-surgical periodontal therapy. Journal of Periodontology 73, 1253-1259. Müller, H. P., Holderrieth, S., Burkhardt, U. & Höffler, U. (2002) In vitro antimicrobial susceptibility of oral strains of Actinobacillus actinomycetemcomitans to seven antibiotics. Journal of Clinical Periodontology 29, 736-742. Rams, T. E., Degener, J. E. & van Winkelhoff, A. J. (2013) Prevalence of β-lactamase-producing bacteria in human periodontitis. Journal of Periodontal Research 48, 493-499. Slots, J. & Reynolds, H. S. (1982) Long-wave UV light fluorescence for identification of black-pigmented Bacteroides spp. Journal of Clinical Microbiology 16, 1148-1151. Bozkurt, B., Karakaya, G. & Kalyoncu, A. F. (2005) Tolerability of moxifloxacin in patients with antibiotic hypersensitivity. Allergolia et Immunopathologia (Madr) 33, 38-41. 2009; 67 2008a; 35 2012; 83 2013; 48 1982; 16 2002; 73 2013; 23 2011; 82 2004; 48 2000; 71 2014; 24 2008; 79 2008b; 35 2013; 92 1999; 4 2012; 39 2008; 31 2012; 58 2014; 85 2014; 63 2010; 81 2007; 34 2005; 45 2014; 65 2001; 21 2010a; 81 1986; 1 2002; 29 2001 2003; 8 2008; 23 2005; 32 2010b; 45 2007; 23 2005; 33 1998; 33 2007; 26 2014; 53 2001; 32 Armitage G. C. (e_1_2_5_7_1) 1999; 4 e_1_2_5_28_1 e_1_2_5_25_1 e_1_2_5_26_1 e_1_2_5_47_1 e_1_2_5_23_1 e_1_2_5_46_1 e_1_2_5_24_1 e_1_2_5_45_1 e_1_2_5_21_1 e_1_2_5_44_1 e_1_2_5_22_1 e_1_2_5_43_1 Doña I. (e_1_2_5_14_1) 2014; 24 e_1_2_5_29_1 Killoy W. J. (e_1_2_5_27_1) 2002; 29 e_1_2_5_20_1 e_1_2_5_41_1 e_1_2_5_15_1 Moreno Villagrana A. P. (e_1_2_5_30_1) 2012; 58 e_1_2_5_38_1 e_1_2_5_39_1 e_1_2_5_17_1 e_1_2_5_36_1 e_1_2_5_9_1 e_1_2_5_16_1 e_1_2_5_37_1 e_1_2_5_8_1 e_1_2_5_11_1 D'Ercole S. (e_1_2_5_13_1) 2008; 31 e_1_2_5_34_1 e_1_2_5_10_1 e_1_2_5_35_1 e_1_2_5_6_1 e_1_2_5_32_1 e_1_2_5_5_1 e_1_2_5_12_1 e_1_2_5_33_1 e_1_2_5_4_1 Slots J. (e_1_2_5_40_1) 1982; 16 e_1_2_5_3_1 e_1_2_5_2_1 e_1_2_5_19_1 e_1_2_5_18_1 e_1_2_5_31_1 The American Academy of Periodontology (e_1_2_5_42_1) 2001 |
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The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one‐stage scaling and root planing (SRP) in... The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in... Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in... |
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| SubjectTerms | Adult Aggregatibacter actinomycetemcomitans - drug effects Aggregatibacter actinomycetemcomitans - isolation & purification Aggressive Periodontitis - drug therapy Aggressive Periodontitis - microbiology Aggressive Periodontitis - therapy Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Bacterial Load - drug effects Bacteroides - drug effects Bacteroides - isolation & purification Clinical outcomes Combined Modality Therapy Dental Plaque - microbiology Dental Scaling - methods Dentistry Drug therapy Female Fluoroquinolones - administration & dosage Fluoroquinolones - therapeutic use Follow-Up Studies generalized aggressive periodontitis Gingival Hemorrhage - drug therapy Gingival Hemorrhage - therapy Gum disease Humans Male Microbiology moxifloxacin Periodontal Attachment Loss - drug therapy Periodontal Attachment Loss - therapy Periodontal Pocket - drug therapy Periodontal Pocket - microbiology Periodontal Pocket - therapy periodontitis/therapy periodontitis/therapy, randomized‐controlled clinical trial Placebos Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - isolation & purification randomized-controlled clinical trial Root Planing - methods Treatment Outcome Young Adult |
| Title | Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
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