Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma

Summary High plasma levels of nicotinamide phosphoribosyltransferase (NAMPT), traditionally considered an intracellular enzyme with a key role in NAD synthesis, have been reported in several oncological, inflammatory and metabolic diseases. We now show that eNAMPT can be actively released by melanom...

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Vydáno v:	Pigment cell and melanoma research Ročník 28; číslo 6; s. 718 - 729
Hlavní autoři:	Grolla, Ambra A., Torretta, Simone, Gnemmi, Ilaria, Amoruso, Angela, Orsomando, Giuseppe, Gatti, Marco, Caldarelli, Antonio, Lim, Dmitry, Penengo, Lorenza, Brunelleschi, Sandra, Genazzani, Armando A., Travelli, Cristina
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Blackwell Publishing Ltd 01.11.2015 Wiley Subscription Services, Inc
Témata:	Animals Autocrine Communication - drug effects Cell Hypoxia - drug effects Cell Line, Tumor cytokine Cytokines - blood Cytokines - metabolism Extracellular Space - enzymology Humans Hydrogen Peroxide - pharmacology Melanoma Melanoma - enzymology Melanoma - pathology Metabolic disorders Mice, Inbred C57BL Monocytes - drug effects Monocytes - metabolism NAD Nicotinamide phosphoribosyltransferase Nicotinamide Phosphoribosyltransferase - blood Nicotinamide Phosphoribosyltransferase - metabolism Paracrine Communication - drug effects Secretory Vesicles - metabolism Skin Neoplasms - enzymology Skin Neoplasms - pathology Tumors visfatin NAD cytokine melanoma Nicotinamide phosphoribosyltransferase visfatin
ISSN:	1755-1471, 1755-148X
On-line přístup:	Získat plný text
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