Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable...

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Bibliographic Details
Published in:	Cell Vol. 166; no. 3; p. 609
Main Authors:	Joyce, M Gordon, Wheatley, Adam K, Thomas, Paul V, Chuang, Gwo-Yu, Soto, Cinque, Bailer, Robert T, Druz, Aliaksandr, Georgiev, Ivelin S, Gillespie, Rebecca A, Kanekiyo, Masaru, Kong, Wing-Pui, Leung, Kwanyee, Narpala, Sandeep N, Prabhakaran, Madhu S, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Asokan, Mangaiarkarasi, Boyington, Jeffrey C, Bylund, Tatsiana, Darko, Sam, Lees, Christopher R, Ransier, Amy, Shen, Chen-Hsiang, Wang, Lingshu, Whittle, James R, Wu, Xueling, Yassine, Hadi M, Santos, Celia, Matsuoka, Yumiko, Tsybovsky, Yaroslav, Baxa, Ulrich, Mullikin, James C, Subbarao, Kanta, Douek, Daniel C, Graham, Barney S, Koup, Richard A, Ledgerwood, Julie E, Roederer, Mario, Shapiro, Lawrence, Kwong, Peter D, Mascola, John R, McDermott, Adrian B
Format:	Journal Article
Language:	English
Published:	United States 28.07.2016
Subjects:	Adult Amino Acid Sequence Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - genetics Antibodies, Viral - immunology B-Lymphocytes - immunology Epitopes, B-Lymphocyte Female Gene Rearrangement, B-Lymphocyte, Heavy Chain Humans Immunologic Memory Influenza A virus - immunology Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - immunology Male Middle Aged Models, Molecular Protein Structure, Tertiary Structure-Activity Relationship Young Adult
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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