Molecular Epidemiology of Tuberculosis in Foreign-Born Persons Living in San Francisco

In San Francisco, 70% of the tuberculosis cases occur among foreign-born persons, mainly from China, the Philippines, and Mexico. We postulate that there are differences in the characteristics and risk factors for tuberculosis among these populations. To determine the clinical, epidemiological and m...

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Veröffentlicht in:American journal of respiratory and critical care medicine Jg. 187; H. 9; S. 998 - 1006
Hauptverfasser: Suwanpimolkul, Gompol, Jarlsberg, Leah G., Grinsdale, Jennifer A., Osmond, Dennis, Kawamura, L. Masae, Hopewell, Philip C., Kato-Maeda, Midori
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York, NY American Thoracic Society 01.05.2013
Schlagworte:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Bacterial diseases
Biological and medical sciences
China - ethnology
Emigrants and Immigrants - statistics & numerical data
Epidemiology
Female
Human bacterial diseases
Humans
Incidence
Infections
Infectious diseases
Intensive care medicine
Male
Medical sciences
Mexico - ethnology
Molecular Epidemiology
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - pathogenicity
Patients
Philippines - ethnology
Phylogeography
Pneumology
Population
Prospective Studies
Risk Factors
San Francisco - epidemiology
Sympatry
Tuberculosis
Tuberculosis - ethnology
Tuberculosis - microbiology
Tuberculosis - transmission
Tuberculosis and atypical mycobacterial infections
United States
North America
America
San Francisco
Mexico
China
Philippines
San Francisco California
United States > US
Intensive care
Immigrant
Respiratory disease
Mycobacterial infection
Infection
epidemiology
foreign-born populations
Tuberculosis
Mycobacterium tuberculosis
Mycobacteriales
Bacteriosis
Mycobacteriaceae
Molecular epidemiology
Bacteria
Actinomycetes
Resuscitation
Public health
ISSN:1073-449X, 1535-4970, 1535-4970
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Zusammenfassung:In San Francisco, 70% of the tuberculosis cases occur among foreign-born persons, mainly from China, the Philippines, and Mexico. We postulate that there are differences in the characteristics and risk factors for tuberculosis among these populations. To determine the clinical, epidemiological and microbiological characteristics of tuberculosis caused by recent infection and rapid evolution in the major groups of foreign-born and the U.S.-born populations. We analyzed data from a 20-year prospective community-based study of the molecular epidemiology of tuberculosis in San Francisco. We included all culture-positive tuberculosis cases in the City during the study period. We calculated and compared incidence rates, clinical and microbiological characteristics, and risk factors for being a secondary case between the various foreign-born and U.S.-born tuberculosis populations. Between 1991 and 2010, there were 4,058 new cases of tuberculosis, of which 1,226 (30%) were U.S.-born and 2,832 (70%) were foreign-born. A total of 3,278 (81%) were culture positive, of which 2,419 (74%) had complete data for analysis. The incidence rate, including the incidence rate of tuberculosis due to recent infection and rapid evolution, decreased significantly in the U.S.-born and the major foreign-born populations. The clinical and microbiological characteristics and the risk factors for tuberculosis due to recent infection differed among the groups. There are differences in the characteristics and the risk factors for tuberculosis due to recent transmission among the major foreign-born and U.S.-born populations in San Francisco. These differences should be considered for the design of targeted tuberculosis control interventions.
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Present address: QIAGEN, 27220 Turnberry Lane, Valencia, CA 91355.
ISSN:1073-449X
1535-4970
1535-4970
DOI:10.1164/rccm.201212-2239OC