Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease

Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, inclu...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:International journal of molecular sciences Ročník 24; číslo 18; s. 14250
Hlavní autoři: Callejón-Leblic, Belén, Sánchez Espirilla, Saida, Gotera-Rivera, Carolina, Santana, Rafael, Díaz-Olivares, Isabel, Marín, José M., Macario, Ciro Casanova, Cosio, Borja García, Fuster, Antonia, García, Ingrid Solanes, de-Torres, Juan P., Feu Collado, Nuria, Cabrera Lopez, Carlos, Amado Diago, Carlos, Romero Plaza, Amparo, Fraysse, Luis Alejandro Padrón, Márquez Martín, Eduardo, Marín Royo, Margarita, Balcells Vilarnau, Eva, Llunell Casanovas, Antonia, Martínez González, Cristina, Galdíz Iturri, Juan Bautista, Lacárcel Bautista, Celia, Gómez-Ariza, José Luis, Pereira-Vega, Antonio, Seijo, Luis, López-Campos, José Luis, Peces-Barba, Germán, García-Barrera, Tamara
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel MDPI AG 01.09.2023
MDPI
Témata:
Biomarkers
Chronic obstructive pulmonary disease
Development and progression
Ethylenediaminetetraacetic acid
Health aspects
Lung cancer
Lung diseases, Obstructive
Medical research
Medicine, Experimental
Metals
Proteins
Taiwan
Spain
ISSN:1422-0067, 1661-6596, 1422-0067
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241814250