Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence

The prefrontal cortex is a crucial regulator of alcohol drinking, and dependence, and other behavioral phenotypes associated with AUD. Comprehensive identification of cell-type specific transcriptomic changes in alcohol dependence will improve our understanding of mechanisms underlying the excessive...

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Vydáno v:	Neurobiology of disease Ročník 190; s. 106361
Hlavní autoři:	Salem, Nihal A., Manzano, Lawrence, Keist, Michael W., Ponomareva, Olga, Roberts, Amanda J., Roberto, Marisa, Mayfield, R. Dayne
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.01.2024 Elsevier
Témata:	Alcohol dependence Alcohol dependence cell-type specific responses Alcoholism - genetics Animals Brain - metabolism Chronic intermittent ethanol exposure Ethanol - toxicity Gene co-expression networks Mice Mice, Inbred C57BL Multimodal data integration Neuroinflammatory Diseases Prefrontal Cortex - metabolism Single nucleus RNA sequencing Spatial transcriptomics Single nucleus RNA sequencing Chronic intermittent ethanol exposure Spatial transcriptomics Gene co-expression networks Alcohol dependence cell-type specific responses Alcohol dependence Multimodal data integration
ISSN:	0969-9961, 1095-953X, 1095-953X
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