Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade

Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq analysis of 187,650 T cells from 31 tissue regions, including tumor, adjacent normal tissues, and lymph nodes (LN), from thre...

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Vydané v:	Cancer cell Ročník 41; číslo 4; s. 776
Hlavní autori:	Pai, Joy A, Hellmann, Matthew D, Sauter, Jennifer L, Mattar, Marissa, Rizvi, Hira, Woo, Hyung Jun, Shah, Nisargbhai, Nguyen, Evelyn M, Uddin, Fathema Z, Quintanal-Villalonga, Alvaro, Chan, Joseph M, Manoj, Parvathy, Allaj, Viola, Baine, Marina K, Bhanot, Umesh K, Jain, Mala, Linkov, Irina, Meng, Fanli, Brown, David, Chaft, Jamie E, Plodkowski, Andrew J, Gigoux, Mathieu, Won, Helen H, Sen, Triparna, Wells, Daniel K, Donoghue, Mark T A, de Stanchina, Elisa, Wolchok, Jedd D, Loomis, Brian, Merghoub, Taha, Rudin, Charles M, Chow, Andrew, Satpathy, Ansuman T
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 10.04.2023
Predmet:	Carcinoma, Non-Small-Cell Lung - drug therapy CD8-Positive T-Lymphocytes Clone Cells Humans Immune Checkpoint Inhibitors - therapeutic use Lung Neoplasms - drug therapy Receptors, Antigen, T-Cell Tumor Microenvironment lung cancer exhausted T cells tumor-specific T cells TCF-1 progenitor exhausted T cells immune checkpoint blockade single-cell RNA/TCR sequencing
ISSN:	1878-3686, 1878-3686
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