Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade
Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq analysis of 187,650 T cells from 31 tissue regions, including tumor, adjacent normal tissues, and lymph nodes (LN), from thre...
Uloženo v:
| Vydáno v: | Cancer cell Ročník 41; číslo 4; s. 776 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
10.04.2023
|
| Témata: | |
| ISSN: | 1878-3686, 1878-3686 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq analysis of 187,650 T cells from 31 tissue regions, including tumor, adjacent normal tissues, and lymph nodes (LN), from three patients with non-small cell lung cancer after immune checkpoint blockade (ICB). Regions with viable cancer cells are enriched for exhausted CD8
T cells, regulatory CD4
T cells (Treg), and follicular helper CD4
T cells (TFH). Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8
T cells are clonally linked to TCF7
SELL
progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8
T, Treg, and TFH cells with proximity to the tumor microenvironment. Finally, longitudinal tracking of tumor-specific CD8
and CD4
T cell clones reveals persistence in the peripheral blood for years after ICB therapy. |
|---|---|
| AbstractList | Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq analysis of 187,650 T cells from 31 tissue regions, including tumor, adjacent normal tissues, and lymph nodes (LN), from three patients with non-small cell lung cancer after immune checkpoint blockade (ICB). Regions with viable cancer cells are enriched for exhausted CD8
T cells, regulatory CD4
T cells (Treg), and follicular helper CD4
T cells (TFH). Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8
T cells are clonally linked to TCF7
SELL
progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8
T, Treg, and TFH cells with proximity to the tumor microenvironment. Finally, longitudinal tracking of tumor-specific CD8
and CD4
T cell clones reveals persistence in the peripheral blood for years after ICB therapy. Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq analysis of 187,650 T cells from 31 tissue regions, including tumor, adjacent normal tissues, and lymph nodes (LN), from three patients with non-small cell lung cancer after immune checkpoint blockade (ICB). Regions with viable cancer cells are enriched for exhausted CD8+ T cells, regulatory CD4+ T cells (Treg), and follicular helper CD4+ T cells (TFH). Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8+ T cells are clonally linked to TCF7+SELL+ progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8+ T, Treg, and TFH cells with proximity to the tumor microenvironment. Finally, longitudinal tracking of tumor-specific CD8+ and CD4+ T cell clones reveals persistence in the peripheral blood for years after ICB therapy.Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq analysis of 187,650 T cells from 31 tissue regions, including tumor, adjacent normal tissues, and lymph nodes (LN), from three patients with non-small cell lung cancer after immune checkpoint blockade (ICB). Regions with viable cancer cells are enriched for exhausted CD8+ T cells, regulatory CD4+ T cells (Treg), and follicular helper CD4+ T cells (TFH). Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8+ T cells are clonally linked to TCF7+SELL+ progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8+ T, Treg, and TFH cells with proximity to the tumor microenvironment. Finally, longitudinal tracking of tumor-specific CD8+ and CD4+ T cell clones reveals persistence in the peripheral blood for years after ICB therapy. |
| Author | Allaj, Viola Linkov, Irina Rizvi, Hira Quintanal-Villalonga, Alvaro Wells, Daniel K Chaft, Jamie E Baine, Marina K Meng, Fanli Hellmann, Matthew D Shah, Nisargbhai de Stanchina, Elisa Mattar, Marissa Gigoux, Mathieu Pai, Joy A Woo, Hyung Jun Chow, Andrew Satpathy, Ansuman T Sauter, Jennifer L Manoj, Parvathy Sen, Triparna Donoghue, Mark T A Rudin, Charles M Brown, David Won, Helen H Merghoub, Taha Chan, Joseph M Plodkowski, Andrew J Nguyen, Evelyn M Bhanot, Umesh K Jain, Mala Wolchok, Jedd D Uddin, Fathema Z Loomis, Brian |
| Author_xml | – sequence: 1 givenname: Joy A surname: Pai fullname: Pai, Joy A organization: Department of Pathology, Stanford University, Stanford, CA, USA; Immunology Program, Stanford University, Stanford, CA, USA – sequence: 2 givenname: Matthew D surname: Hellmann fullname: Hellmann, Matthew D organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 3 givenname: Jennifer L surname: Sauter fullname: Sauter, Jennifer L organization: Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 4 givenname: Marissa surname: Mattar fullname: Mattar, Marissa organization: Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 5 givenname: Hira surname: Rizvi fullname: Rizvi, Hira organization: Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 6 givenname: Hyung Jun surname: Woo fullname: Woo, Hyung Jun organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 7 givenname: Nisargbhai surname: Shah fullname: Shah, Nisargbhai organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 8 givenname: Evelyn M surname: Nguyen fullname: Nguyen, Evelyn M organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Cancer Biology Program, Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 9 givenname: Fathema Z surname: Uddin fullname: Uddin, Fathema Z organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 10 givenname: Alvaro surname: Quintanal-Villalonga fullname: Quintanal-Villalonga, Alvaro organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 11 givenname: Joseph M surname: Chan fullname: Chan, Joseph M organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 12 givenname: Parvathy surname: Manoj fullname: Manoj, Parvathy organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 13 givenname: Viola surname: Allaj fullname: Allaj, Viola organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 14 givenname: Marina K surname: Baine fullname: Baine, Marina K organization: Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 15 givenname: Umesh K surname: Bhanot fullname: Bhanot, Umesh K organization: Precision Pathology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 16 givenname: Mala surname: Jain fullname: Jain, Mala organization: Precision Pathology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 17 givenname: Irina surname: Linkov fullname: Linkov, Irina organization: Precision Pathology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 18 givenname: Fanli surname: Meng fullname: Meng, Fanli organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 19 givenname: David surname: Brown fullname: Brown, David organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 20 givenname: Jamie E surname: Chaft fullname: Chaft, Jamie E organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA – sequence: 21 givenname: Andrew J surname: Plodkowski fullname: Plodkowski, Andrew J organization: Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 22 givenname: Mathieu surname: Gigoux fullname: Gigoux, Mathieu organization: Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 23 givenname: Helen H surname: Won fullname: Won, Helen H organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 24 givenname: Triparna surname: Sen fullname: Sen, Triparna organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA – sequence: 25 givenname: Daniel K surname: Wells fullname: Wells, Daniel K organization: Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA; Santa Ana Bio, Alameda, CA, USA – sequence: 26 givenname: Mark T A surname: Donoghue fullname: Donoghue, Mark T A organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 27 givenname: Elisa surname: de Stanchina fullname: de Stanchina, Elisa organization: Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 28 givenname: Jedd D surname: Wolchok fullname: Wolchok, Jedd D organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 29 givenname: Brian surname: Loomis fullname: Loomis, Brian organization: Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 30 givenname: Taha surname: Merghoub fullname: Merghoub, Taha organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 31 givenname: Charles M surname: Rudin fullname: Rudin, Charles M organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 32 givenname: Andrew surname: Chow fullname: Chow, Andrew email: chowa1@mskcc.org organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: chowa1@mskcc.org – sequence: 33 givenname: Ansuman T surname: Satpathy fullname: Satpathy, Ansuman T email: satpathy@stanford.edu organization: Department of Pathology, Stanford University, Stanford, CA, USA; Immunology Program, Stanford University, Stanford, CA, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA; Parker Institute for Cancer Immunotherapy, Stanford University, Stanford, CA, USA. Electronic address: satpathy@stanford.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37001526$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUE1LxDAQDbLifugvECRHL61Juk3Toyx-wYKX9bwk0-ma3TapSSt486fbxRWEgXkMb968N3Mycd4hIdecpZxxebdPAbBpUsFElrKxWHlGZlwVKsmkkpN_eErmMe7ZuMWL8oJMs2LEuZAz8r22DvUOaR80WLejAT9RN5FC451uaBf8Dp3tfYhUu4qO013SY2hphyHa2KMDpL6m_dD6kMQOwdYW6IYevUVaDeGoatt2cEjhHeHQeet6ahoPB13hJTmvx3t4deoL8vb4sFk9J-vXp5fV_TqBpWR9onJeQpYbjZlaQr40CoRUQmgDRkMmgTGT16o0xRiS1dmygJqhqmpEI7mQYkFuf3XHRB8Dxn7b2nj0qB36IW5FUWZlyXjJR-rNiTqYFqttF2yrw9f272viB2IRdQk |
| CitedBy_id | crossref_primary_10_1042_BSR20231723 crossref_primary_10_1097_JP9_0000000000000237 crossref_primary_10_1016_j_celrep_2025_116190 crossref_primary_10_1016_j_ymthe_2024_12_057 crossref_primary_10_1053_j_gastro_2025_03_019 crossref_primary_10_1016_j_tig_2023_07_005 crossref_primary_10_1016_j_apsb_2024_04_022 crossref_primary_10_1038_s41571_023_00830_6 crossref_primary_10_1111_imr_13356 crossref_primary_10_1016_j_immuni_2023_09_005 crossref_primary_10_1016_j_bbcan_2024_189183 crossref_primary_10_1016_j_celrep_2024_115136 crossref_primary_10_1158_0008_5472_CAN_23_2716 crossref_primary_10_1002_cam4_70659 crossref_primary_10_3389_fimmu_2025_1674174 crossref_primary_10_3389_fimmu_2024_1426418 crossref_primary_10_1146_annurev_immunol_082223_044122 crossref_primary_10_1186_s12920_024_01859_x crossref_primary_10_1002_smll_202506429 crossref_primary_10_1038_s41571_025_01003_3 crossref_primary_10_1186_s12943_024_02179_5 crossref_primary_10_1016_j_coi_2024_102506 crossref_primary_10_1038_s41392_023_01674_3 crossref_primary_10_1002_qub2_70006 crossref_primary_10_1111_cas_16177 crossref_primary_10_7554_eLife_100002 crossref_primary_10_1038_s41556_025_01753_3 crossref_primary_10_3389_fimmu_2025_1562797 crossref_primary_10_1146_annurev_immunol_101320_020220 crossref_primary_10_1007_s00432_024_05645_1 crossref_primary_10_1016_j_ccell_2023_12_013 crossref_primary_10_1016_j_ccell_2024_06_009 crossref_primary_10_1126_sciimmunol_ads2957 crossref_primary_10_1016_j_xgen_2025_100842 crossref_primary_10_1038_s41423_025_01321_7 crossref_primary_10_1016_j_jtho_2025_05_024 crossref_primary_10_1016_j_ccell_2023_08_013 crossref_primary_10_1016_j_tcb_2023_04_001 crossref_primary_10_1007_s12672_025_01769_z crossref_primary_10_1016_j_biomaterials_2025_123087 crossref_primary_10_1016_j_xcrm_2024_101882 crossref_primary_10_1038_s41467_024_52098_8 crossref_primary_10_3389_fonc_2024_1342624 crossref_primary_10_1016_j_csbj_2025_01_009 crossref_primary_10_1016_j_imbio_2024_152805 crossref_primary_10_1186_s12943_024_02104_w crossref_primary_10_1038_s41568_023_00615_0 crossref_primary_10_1038_s41590_023_01659_y crossref_primary_10_1080_22221751_2025_2466695 crossref_primary_10_3389_fphar_2023_1295442 crossref_primary_10_7554_eLife_100002_3 crossref_primary_10_1111_jcmm_70556 crossref_primary_10_1186_s40364_024_00643_4 crossref_primary_10_3389_fimmu_2024_1449291 crossref_primary_10_3389_fonc_2025_1625369 crossref_primary_10_1158_2326_6066_CIR_23_0786 crossref_primary_10_3389_fonc_2025_1635418 crossref_primary_10_3389_fimmu_2025_1640500 crossref_primary_10_1007_s12033_024_01144_3 crossref_primary_10_1016_j_ymthe_2025_09_006 crossref_primary_10_1038_s41592_024_02530_0 crossref_primary_10_1182_bloodadvances_2023011287 crossref_primary_10_1016_j_critrevonc_2024_104309 crossref_primary_10_1038_s41571_025_01021_1 crossref_primary_10_1126_sciimmunol_adu7341 crossref_primary_10_1016_j_humimm_2024_111087 crossref_primary_10_1097_CM9_0000000000003708 crossref_primary_10_1186_s13062_024_00514_w crossref_primary_10_1016_j_stem_2025_05_011 crossref_primary_10_3389_fimmu_2024_1304183 crossref_primary_10_1136_jitc_2024_010685 crossref_primary_10_1007_s40259_024_00700_2 crossref_primary_10_1038_s41568_024_00681_y crossref_primary_10_3389_fimmu_2025_1587658 crossref_primary_10_1186_s12951_025_03537_1 crossref_primary_10_1038_s41467_025_56659_3 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2023 Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.ccell.2023.03.009 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1878-3686 |
| ExternalDocumentID | 37001526 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R35 CA232130 – fundername: NCI NIH HHS grantid: U01 CA260852 – fundername: NCI NIH HHS grantid: T32 CA009207 – fundername: NIAID NIH HHS grantid: T32 AI007290 – fundername: NCI NIH HHS grantid: K08 CA248723 – fundername: NCI NIH HHS grantid: R01 CA197936 – fundername: NCI NIH HHS grantid: R01 CA056821 – fundername: NCI NIH HHS grantid: R35 CA263816 – fundername: NCI NIH HHS grantid: P01 CA129243 – fundername: NCI NIH HHS grantid: U24 CA213274 |
| GroupedDBID | --- --K 0R~ 1~5 29B 2WC 4.4 457 4G. 53G 5GY 62- 6J9 7-5 AAEDT AAEDW AAFWJ AAKRW AAKUH AALRI AAMRU AAVLU AAXUO AAYWO ABDGV ABJNI ABMAC ACGFO ACGFS ACVFH ADBBV ADCNI ADEZE ADVLN AEFWE AENEX AEUPX AEXQZ AFPUW AFTJW AGCQF AGKMS AIGII AITUG AKAPO AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EFKBS EIF F5P FCP FDB FEDTE FIRID HVGLF IH2 IHE IXB J1W JIG M3Z M41 NPM O-L O9- OK1 P2P ROL RPZ SES SSZ TR2 UDS 7X8 |
| ID | FETCH-LOGICAL-c460t-8519c35bae384c54b8c26822abcbac36c00b5f89b70160f347cf0e8dfeeb61262 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 82 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000997202100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1878-3686 |
| IngestDate | Mon Sep 29 04:42:32 EDT 2025 Mon Jul 21 05:53:43 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | lung cancer exhausted T cells tumor-specific T cells TCF-1 progenitor exhausted T cells immune checkpoint blockade single-cell RNA/TCR sequencing |
| Language | English |
| License | Copyright © 2023 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c460t-8519c35bae384c54b8c26822abcbac36c00b5f89b70160f347cf0e8dfeeb61262 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://pmc.ncbi.nlm.nih.gov/articles/PMC10563767/pdf/nihms-1925035.pdf |
| PMID | 37001526 |
| PQID | 2793990191 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2793990191 pubmed_primary_37001526 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-04-10 |
| PublicationDateYYYYMMDD | 2023-04-10 |
| PublicationDate_xml | – month: 04 year: 2023 text: 2023-04-10 day: 10 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cancer cell |
| PublicationTitleAlternate | Cancer Cell |
| PublicationYear | 2023 |
| References | 37001525 - Cancer Cell. 2023 Apr 10;41(4):653-655 |
| References_xml | – reference: 37001525 - Cancer Cell. 2023 Apr 10;41(4):653-655 |
| SSID | ssj0016179 |
| Score | 2.647375 |
| Snippet | Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report... Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 776 |
| SubjectTerms | Carcinoma, Non-Small-Cell Lung - drug therapy CD8-Positive T-Lymphocytes Clone Cells Humans Immune Checkpoint Inhibitors - therapeutic use Lung Neoplasms - drug therapy Receptors, Antigen, T-Cell Tumor Microenvironment |
| Title | Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37001526 https://www.proquest.com/docview/2793990191 |
| Volume | 41 |
| WOSCitedRecordID | wos000997202100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7Uinjx_agvRvAaTfPa5CQiFi8tPVTorexOdkupJrVJPfvTnUlSehPBQ3JYCNnMfpn9dp5C3IWBMVq7gWM9j4tq-x0nwZSz0VwrQ43WKFU1m5D9fjwaJYPG4FY0YZUrnVgp6jRHtpE_eAQk9uEkncf5p8Ndo9i72rTQ2BQtn6gMo1qO1l4E2p2Z_nZiDgGI4mhVdaiK70K2jN9z9_C6yukvHLPaa7r7_53lgdhrWCY81bA4FBsmOxI7vcaPfiy-6QhqSJNAuVA0MgEu5ERABHxnZg4ctWX4Z18UoLIUaHTisBKHOdvXiopoQ26hXH7kC4fTNTnkCIbAn1tAnfwIU04-MUC4wNk8n2YlaNo7Zyo1J-Kt-zJ8fnWaXgwOBpFbOkTMEvRDrYwfBxgGOkYvInKhNGqFfoSuq0MbJ1pyyTrrBxKta-LUEhSIREXeqdjK8sycC1AYh1LSpbQNIp_4RhoaOgnRK1CmEtvidiXbMWGd560yky-L8Vq6bXFWL9B4XhflGPvsQA-96OIPT1-KXV53dgp13CvRsiRgcy228aucFoubCkR07w96P-mC1Dw |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lineage+tracing+reveals+clonal+progenitors+and+long-term+persistence+of+tumor-specific+T+cells+during+immune+checkpoint+blockade&rft.jtitle=Cancer+cell&rft.au=Pai%2C+Joy+A&rft.au=Hellmann%2C+Matthew+D&rft.au=Sauter%2C+Jennifer+L&rft.au=Mattar%2C+Marissa&rft.date=2023-04-10&rft.issn=1878-3686&rft.eissn=1878-3686&rft.volume=41&rft.issue=4&rft.spage=776&rft_id=info:doi/10.1016%2Fj.ccell.2023.03.009&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1878-3686&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1878-3686&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1878-3686&client=summon |