Trends in Sudden Cardiac Death Among Adults Aged 25 to 44 Years in the United States: An Analysis of 2 Large US Databases

Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census re...

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Vydané v:	Journal of the American Heart Association Ročník 14; číslo 1; s. e035722
Hlavní autori:	Zuin, Marco, Mohanty, Sanghamitra, Aggarwal, Rahul, Bertini, Matteo, Bikdeli, Behnood, Hamade, Nada, Leyva, Hannah, Natale, Andrea, Boriani, Giuseppe, Piazza, Gregory
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England John Wiley and Sons Inc 07.01.2025 Wiley
Predmet:	Adult Age Distribution cardiovascular disease Cause of Death - trends Databases, Factual Death, Sudden, Cardiac - epidemiology Female Humans Male mortality Nutrition Surveys Original Research Prevalence Risk Factors Sex Distribution sudden cardiac death Time Factors trend United States - epidemiology United States mortality cardiovascular disease sudden cardiac death trend
ISSN:	2047-9980, 2047-9980
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Abstract	Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region. Mortality data were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020. Age-adjusted mortality rates were assessed using the Joinpoint regression modeling and expressed as estimated average annual percentage change with relative 95% CIs. Trends in prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke, which may have contributed to SCD-related mortality over the same period, were obtained from the National Health and Nutrition Examination Survey. From 1999 to 2020, 10 516 US early adults aged 25 to 44 years had SCD (7832 men and 2684 women), resulting in 3.72 deaths per 1000 population, or a mean of 478 deaths annually. The relative age-adjusted mortality rate increased linearly (average annual percentage change: +1.0% [95% CI, 0.3-1.8]), without sex differences. The age-adjusted mortality rate increase was more pronounced in Black patients, Hispanic/Latinx patients, and residents of rural areas. Higher absolute numbers of SCDs were clustered in the South (47.6%). During the same period, the prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke plateaued. SCD-related mortality associated with opioids/stimulants overdose significantly increased over the entire study period. SCD-related mortality among early adults has increased over the last 2 decades in the United States with notable racial and regional disparities.
AbstractList	Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region. Mortality data were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020. Age-adjusted mortality rates were assessed using the Joinpoint regression modeling and expressed as estimated average annual percentage change with relative 95% CIs. Trends in prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke, which may have contributed to SCD-related mortality over the same period, were obtained from the National Health and Nutrition Examination Survey. From 1999 to 2020, 10 516 US early adults aged 25 to 44 years had SCD (7832 men and 2684 women), resulting in 3.72 deaths per 1000 population, or a mean of 478 deaths annually. The relative age-adjusted mortality rate increased linearly (average annual percentage change: +1.0% [95% CI, 0.3-1.8]), without sex differences. The age-adjusted mortality rate increase was more pronounced in Black patients, Hispanic/Latinx patients, and residents of rural areas. Higher absolute numbers of SCDs were clustered in the South (47.6%). During the same period, the prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke plateaued. SCD-related mortality associated with opioids/stimulants overdose significantly increased over the entire study period. SCD-related mortality among early adults has increased over the last 2 decades in the United States with notable racial and regional disparities. Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region.BACKGROUNDSudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region.Mortality data were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020. Age-adjusted mortality rates were assessed using the Joinpoint regression modeling and expressed as estimated average annual percentage change with relative 95% CIs. Trends in prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke, which may have contributed to SCD-related mortality over the same period, were obtained from the National Health and Nutrition Examination Survey. From 1999 to 2020, 10 516 US early adults aged 25 to 44 years had SCD (7832 men and 2684 women), resulting in 3.72 deaths per 1000 population, or a mean of 478 deaths annually. The relative age-adjusted mortality rate increased linearly (average annual percentage change: +1.0% [95% CI, 0.3-1.8]), without sex differences. The age-adjusted mortality rate increase was more pronounced in Black patients, Hispanic/Latinx patients, and residents of rural areas. Higher absolute numbers of SCDs were clustered in the South (47.6%). During the same period, the prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke plateaued. SCD-related mortality associated with opioids/stimulants overdose significantly increased over the entire study period.METHODS AND RESULTSMortality data were retrieved from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020. Age-adjusted mortality rates were assessed using the Joinpoint regression modeling and expressed as estimated average annual percentage change with relative 95% CIs. Trends in prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke, which may have contributed to SCD-related mortality over the same period, were obtained from the National Health and Nutrition Examination Survey. From 1999 to 2020, 10 516 US early adults aged 25 to 44 years had SCD (7832 men and 2684 women), resulting in 3.72 deaths per 1000 population, or a mean of 478 deaths annually. The relative age-adjusted mortality rate increased linearly (average annual percentage change: +1.0% [95% CI, 0.3-1.8]), without sex differences. The age-adjusted mortality rate increase was more pronounced in Black patients, Hispanic/Latinx patients, and residents of rural areas. Higher absolute numbers of SCDs were clustered in the South (47.6%). During the same period, the prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke plateaued. SCD-related mortality associated with opioids/stimulants overdose significantly increased over the entire study period.SCD-related mortality among early adults has increased over the last 2 decades in the United States with notable racial and regional disparities.CONCLUSIONSSCD-related mortality among early adults has increased over the last 2 decades in the United States with notable racial and regional disparities. Background Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD‐related mortality in the United States from 1999 to 2020 among early adults to determine differences by sex, ethnoracial groups, urbanization, and census region. Methods and Results Mortality data were retrieved from the Centers for Disease Control and Prevention Wide‐Ranging Online Data for Epidemiologic Research (CDC WONDER) data set from 1999 to 2020. Age‐adjusted mortality rates were assessed using the Joinpoint regression modeling and expressed as estimated average annual percentage change with relative 95% CIs. Trends in prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke, which may have contributed to SCD‐related mortality over the same period, were obtained from the National Health and Nutrition Examination Survey. From 1999 to 2020, 10 516 US early adults aged 25 to 44 years had SCD (7832 men and 2684 women), resulting in 3.72 deaths per 1000 population, or a mean of 478 deaths annually. The relative age‐adjusted mortality rate increased linearly (average annual percentage change: +1.0% [95% CI, 0.3–1.8]), without sex differences. The age‐adjusted mortality rate increase was more pronounced in Black patients, Hispanic/Latinx patients, and residents of rural areas. Higher absolute numbers of SCDs were clustered in the South (47.6%). During the same period, the prevalence of coronary artery disease/myocardial infarction, heart failure, and stroke plateaued. SCD‐related mortality associated with opioids/stimulants overdose significantly increased over the entire study period. Conclusions SCD‐related mortality among early adults has increased over the last 2 decades in the United States with notable racial and regional disparities.
Author	Leyva, Hannah Bikdeli, Behnood Zuin, Marco Bertini, Matteo Boriani, Giuseppe Natale, Andrea Mohanty, Sanghamitra Hamade, Nada Aggarwal, Rahul Piazza, Gregory
AuthorAffiliation	4 Heart and Vascular Center Brigham and Women’s Hospital and Harvard Medical School Boston MA 9 Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia, Policlinico di Modena Modena Italy 10 Division of Cardiovascular Medicine Brigham and Women’s Hospital, Harvard Medical School Boston MA 6 Yale/YNHH Center for Outcomes Research and Evaluation New Haven CT 2 Department of Cardio‐Thoraco‐Vascular Sciences and Public Health University of Padova Italy 1 Department of Translational Medicine University of Ferrara Italy 5 Cardiovascular Medicine Division and Thrombosis Research Group Brigham and Women’s Hospital, Harvard Medical School Boston MA 3 Texas Cardiac Arrhythmia Institute St. David’s Medical Center Austin TX 7 Interventional Electrophysiology Scripps Clinic San Diego CA 8 Department of Internal Medicine, Metro Health Medical Center Case Western Reserve University School of Medicine Cleveland OH
AuthorAffiliation_xml	– name: 4 Heart and Vascular Center Brigham and Women’s Hospital and Harvard Medical School Boston MA – name: 2 Department of Cardio‐Thoraco‐Vascular Sciences and Public Health University of Padova Italy – name: 10 Division of Cardiovascular Medicine Brigham and Women’s Hospital, Harvard Medical School Boston MA – name: 1 Department of Translational Medicine University of Ferrara Italy – name: 9 Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia, Policlinico di Modena Modena Italy – name: 6 Yale/YNHH Center for Outcomes Research and Evaluation New Haven CT – name: 3 Texas Cardiac Arrhythmia Institute St. David’s Medical Center Austin TX – name: 5 Cardiovascular Medicine Division and Thrombosis Research Group Brigham and Women’s Hospital, Harvard Medical School Boston MA – name: 8 Department of Internal Medicine, Metro Health Medical Center Case Western Reserve University School of Medicine Cleveland OH – name: 7 Interventional Electrophysiology Scripps Clinic San Diego CA
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 M. Zuin, S. Mohanty, R. Aggarwal, and M. Bertini contributed equally. Supplemental Material is available at https://www.ahajournals.org/doi/suppl/10.1161/JAHA.124.035722 This manuscript was sent to Shaan Khurshid, MD, MPH, Assistant Editor, for review by expert referees, editorial decision, and final disposition. For Sources of Funding and Disclosures, see page 11. See Editorial by Quinn and Guseh.
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Snippet	Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in SCD-related... Background Sudden cardiac death (SCD) in early adults aged 25 to 44 years represents an important and unexpected cause of death. We assessed trends in...
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SubjectTerms	Adult Age Distribution cardiovascular disease Cause of Death - trends Databases, Factual Death, Sudden, Cardiac - epidemiology Female Humans Male mortality Nutrition Surveys Original Research Prevalence Risk Factors Sex Distribution sudden cardiac death Time Factors trend United States - epidemiology
Title	Trends in Sudden Cardiac Death Among Adults Aged 25 to 44 Years in the United States: An Analysis of 2 Large US Databases
URI	https://www.ncbi.nlm.nih.gov/pubmed/39692035 https://www.proquest.com/docview/3146950536 https://pubmed.ncbi.nlm.nih.gov/PMC12054444 https://doaj.org/article/db3a8fdce8664d1789dca4b958ce9655
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