Patients with Nontuberculous Mycobacterial Lung Disease Exhibit Unique Body and Immune Phenotypes

Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease....

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Vydané v:	American journal of respiratory and critical care medicine Ročník 187; číslo 2; s. 197 - 205
Hlavní autori:	Kartalija, Marinka, Ovrutsky, Alida R., Bryan, Courtney L., Pott, Gregory B., Fantuzzi, Giamila, Thomas, Jacob, Strand, Matthew J., Bai, Xiyuan, Ramamoorthy, Preveen, Rothman, Micol S., Nagabhushanam, Vijaya, McDermott, Michael, Levin, Adrah R., Frazer-Abel, Ashley, Giclas, Patricia C., Korner, Judith, Iseman, Michael D., Shapiro, Leland, Chan, Edward D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York, NY American Thoracic Society 15.01.2013
Predmet:	Adipokines - blood Adipose Tissue - physiology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Body fat Body Mass Index Case-Control Studies Chronic obstructive pulmonary disease Cytokines Cytokines - blood Disease Susceptibility - blood Disease Susceptibility - immunology Drug toxicity and drugs side effects treatment Female Funnel Chest - complications Gender Habitus Health care Humans Intensive care medicine Lung diseases Male Medical sciences Middle Aged Mycobacterium Infections, Nontuberculous - etiology Mycobacterium Infections, Nontuberculous - immunology Pharmacology. Drug treatments Phenotype Scoliosis Scoliosis - complications Toxicity: blood Tuberculosis Tumor necrosis factor-TNF Womens health adiponectin Skin disease Intensive care Deformation Spine Diseases of the osteoarticular system Spine disease Mycobacterial infection Marfan syndrome Osteoarticular system Scoliosis Systemic disease Chest wall Resuscitation Human Connective tissue disease Lung disease Elastic tissue disease Respiratory disease Congenital disease Genetic disease Infection Phenotype Malformation Leptin Bacteriosis Pectus excavatum
ISSN:	1073-449X, 1535-4970, 1535-4970
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Shrnutí:	Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease. To compare body morphotype, serum adipokine levels, and whole-blood cytokine responses of patients with pulmonary nontuberculous mycobacteria (pNTM) with contemporary control subjects who are well matched demographically. We enrolled 103 patients with pNTM and 101 uninfected control subjects of similar demographics. Body mass index and body fat were quantified. All patients with pNTM and a subset of control subjects were evaluated for scoliosis and pectus excavatum. Serum leptin and adiponectin were measured. Specific cytokines important to host-defense against mycobacteria were measured in whole blood before and after stimulation. Patients with pNTM and control subjects were well matched for age, gender, and race. Patients with pNTM had significantly lower body mass index and body fat and were significantly taller than control subjects. Scoliosis and pectus excavatum were significantly more prevalent in patients with pNTM. The normal relationships between the adipokines and body fat were lost in the patients with pNTM, a novel finding. IFN-γ and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM. This is the first study to comprehensively compare body morphotype, adipokines, and cytokine responses between patients with NTM lung disease and demographically matched controls. Our findings suggest a novel, predisposing immunophenotype that should be mechanistically defined.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	1073-449X 1535-4970 1535-4970
DOI:	10.1164/rccm.201206-1035OC