Patients with Nontuberculous Mycobacterial Lung Disease Exhibit Unique Body and Immune Phenotypes
Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease....
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| Vydáno v: | American journal of respiratory and critical care medicine Ročník 187; číslo 2; s. 197 - 205 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
New York, NY
American Thoracic Society
15.01.2013
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| Témata: | |
| ISSN: | 1073-449X, 1535-4970, 1535-4970 |
| On-line přístup: | Získat plný text |
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| Abstract | Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease.
To compare body morphotype, serum adipokine levels, and whole-blood cytokine responses of patients with pulmonary nontuberculous mycobacteria (pNTM) with contemporary control subjects who are well matched demographically.
We enrolled 103 patients with pNTM and 101 uninfected control subjects of similar demographics. Body mass index and body fat were quantified. All patients with pNTM and a subset of control subjects were evaluated for scoliosis and pectus excavatum. Serum leptin and adiponectin were measured. Specific cytokines important to host-defense against mycobacteria were measured in whole blood before and after stimulation.
Patients with pNTM and control subjects were well matched for age, gender, and race. Patients with pNTM had significantly lower body mass index and body fat and were significantly taller than control subjects. Scoliosis and pectus excavatum were significantly more prevalent in patients with pNTM. The normal relationships between the adipokines and body fat were lost in the patients with pNTM, a novel finding. IFN-γ and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM.
This is the first study to comprehensively compare body morphotype, adipokines, and cytokine responses between patients with NTM lung disease and demographically matched controls. Our findings suggest a novel, predisposing immunophenotype that should be mechanistically defined. |
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| AbstractList | Rationale: Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease. Objectives: To compare body morphotype, serum adipokine levels, and whole-blood cytokine responses of patients with pulmonary nontuberculous mycobacteria (pNTM) with contemporary control subjects who are well matched demographically. Methods: We enrolled 103 patients with pNTM and 101 uninfected control subjects of similar demographics. Body mass index and body fat were quantified. All patients with pNTM and a subset of control subjects were evaluated for scoliosis and pectus excavatum. Serum leptin and adiponectin were measured. Specific cytokines important to host-defense against mycobacteria were measured in whole blood before and after stimulation. Measurements and Main Results: Patients with pNTM and control subjects were well matched for age, gender, and race. Patients with pNTM had significantly lower body mass index and body fat and were significantly taller than control subjects. Scoliosis and pectus excavatum were significantly more prevalent in patients with pNTM. The normal relationships between the adipokines and body fat were lost in the patients with pNTM, a novel finding. IFN-γ and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM. Conclusions: This is the first study to comprehensively compare body morphotype, adipokines, and cytokine responses between patients with NTM lung disease and demographically matched controls. Our findings suggest a novel, predisposing immunophenotype that should be mechanistically defined. Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease. To compare body morphotype, serum adipokine levels, and whole-blood cytokine responses of patients with pulmonary nontuberculous mycobacteria (pNTM) with contemporary control subjects who are well matched demographically. We enrolled 103 patients with pNTM and 101 uninfected control subjects of similar demographics. Body mass index and body fat were quantified. All patients with pNTM and a subset of control subjects were evaluated for scoliosis and pectus excavatum. Serum leptin and adiponectin were measured. Specific cytokines important to host-defense against mycobacteria were measured in whole blood before and after stimulation. Patients with pNTM and control subjects were well matched for age, gender, and race. Patients with pNTM had significantly lower body mass index and body fat and were significantly taller than control subjects. Scoliosis and pectus excavatum were significantly more prevalent in patients with pNTM. The normal relationships between the adipokines and body fat were lost in the patients with pNTM, a novel finding. IFN-γ and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM. This is the first study to comprehensively compare body morphotype, adipokines, and cytokine responses between patients with NTM lung disease and demographically matched controls. Our findings suggest a novel, predisposing immunophenotype that should be mechanistically defined. Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease.RATIONALEAmong patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease.To compare body morphotype, serum adipokine levels, and whole-blood cytokine responses of patients with pulmonary nontuberculous mycobacteria (pNTM) with contemporary control subjects who are well matched demographically.OBJECTIVESTo compare body morphotype, serum adipokine levels, and whole-blood cytokine responses of patients with pulmonary nontuberculous mycobacteria (pNTM) with contemporary control subjects who are well matched demographically.We enrolled 103 patients with pNTM and 101 uninfected control subjects of similar demographics. Body mass index and body fat were quantified. All patients with pNTM and a subset of control subjects were evaluated for scoliosis and pectus excavatum. Serum leptin and adiponectin were measured. Specific cytokines important to host-defense against mycobacteria were measured in whole blood before and after stimulation.METHODSWe enrolled 103 patients with pNTM and 101 uninfected control subjects of similar demographics. Body mass index and body fat were quantified. All patients with pNTM and a subset of control subjects were evaluated for scoliosis and pectus excavatum. Serum leptin and adiponectin were measured. Specific cytokines important to host-defense against mycobacteria were measured in whole blood before and after stimulation.Patients with pNTM and control subjects were well matched for age, gender, and race. Patients with pNTM had significantly lower body mass index and body fat and were significantly taller than control subjects. Scoliosis and pectus excavatum were significantly more prevalent in patients with pNTM. The normal relationships between the adipokines and body fat were lost in the patients with pNTM, a novel finding. IFN-γ and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM.MEASUREMENTS AND MAIN RESULTSPatients with pNTM and control subjects were well matched for age, gender, and race. Patients with pNTM had significantly lower body mass index and body fat and were significantly taller than control subjects. Scoliosis and pectus excavatum were significantly more prevalent in patients with pNTM. The normal relationships between the adipokines and body fat were lost in the patients with pNTM, a novel finding. IFN-γ and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM.This is the first study to comprehensively compare body morphotype, adipokines, and cytokine responses between patients with NTM lung disease and demographically matched controls. Our findings suggest a novel, predisposing immunophenotype that should be mechanistically defined.CONCLUSIONSThis is the first study to comprehensively compare body morphotype, adipokines, and cytokine responses between patients with NTM lung disease and demographically matched controls. Our findings suggest a novel, predisposing immunophenotype that should be mechanistically defined. Among patients with nontuberculous mycobacterial lung disease is a subset of previously healthy women with a slender body morphotype, often with scoliosis and/or pectus excavatum. We hypothesize that unidentified factors predispose these individuals to pulmonary nontuberculous mycobacterial disease. To compare body morphotype, serum adipokine levels, and whole-blood cytokine responses of patients with pulmonary nontuberculous mycobacteria (pNTM) with contemporary control subjects who are well matched demographically. We enrolled 103 patients with pNTM and 101 uninfected control subjects of similar demographics. Body mass index and body fat were quantified. All patients with pNTM and a subset of control subjects were evaluated for scoliosis and pectus excavatum. Serum leptin and adiponectin were measured. Specific cytokines important to host-defense against mycobacteria were measured in whole blood before and after stimulation. Patients with pNTM and control subjects were well matched for age, gender, and race. Patients with pNTM had significantly lower body mass index and body fat and were significantly taller than control subjects. Scoliosis and pectus excavatum were significantly more prevalent in patients with pNTM. The normal relationships between the adipokines and body fat were lost in the patients with pNTM, a novel finding. IFN-γ and IL-10 levels were significantly suppressed in stimulated whole blood of patients with pNTM. This is the first study to comprehensively compare body morphotype, adipokines, and cytokine responses between patients with NTM lung disease and demographically matched controls. Our findings suggest a novel, predisposing immunophenotype that should be mechanistically defined. |
| Author | Ramamoorthy, Preveen McDermott, Michael Fantuzzi, Giamila Bryan, Courtney L. Shapiro, Leland Chan, Edward D. Strand, Matthew J. Giclas, Patricia C. Rothman, Micol S. Frazer-Abel, Ashley Iseman, Michael D. Nagabhushanam, Vijaya Bai, Xiyuan Ovrutsky, Alida R. Pott, Gregory B. Korner, Judith Kartalija, Marinka Thomas, Jacob Levin, Adrah R. |
| Author_xml | – sequence: 1 givenname: Marinka surname: Kartalija fullname: Kartalija, Marinka organization: Division of Infectious Diseases – sequence: 2 givenname: Alida R. surname: Ovrutsky fullname: Ovrutsky, Alida R. organization: Departments of Medicine and Academic Affairs – sequence: 3 givenname: Courtney L. surname: Bryan fullname: Bryan, Courtney L. organization: Division of Infectious Diseases, Denver Veterans Affairs Medical Center, Denver, Colorado – sequence: 4 givenname: Gregory B. surname: Pott fullname: Pott, Gregory B. organization: Division of Infectious Diseases, Denver Veterans Affairs Medical Center, Denver, Colorado – sequence: 5 givenname: Giamila surname: Fantuzzi fullname: Fantuzzi, Giamila organization: Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois; and – sequence: 6 givenname: Jacob surname: Thomas fullname: Thomas, Jacob organization: Department of Biostatistics – sequence: 7 givenname: Matthew J. surname: Strand fullname: Strand, Matthew J. organization: Department of Biostatistics, Division of Biostatistics, and – sequence: 8 givenname: Xiyuan surname: Bai fullname: Bai, Xiyuan organization: Division of Pulmonary Sciences and Critical Care Medicine, and, Departments of Medicine and Academic Affairs – sequence: 9 givenname: Preveen surname: Ramamoorthy fullname: Ramamoorthy, Preveen organization: Departments of Medicine and Academic Affairs – sequence: 10 givenname: Micol S. surname: Rothman fullname: Rothman, Micol S. organization: Division of Endocrinology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado – sequence: 11 givenname: Vijaya surname: Nagabhushanam fullname: Nagabhushanam, Vijaya organization: Departments of Medicine and Academic Affairs – sequence: 12 givenname: Michael surname: McDermott fullname: McDermott, Michael organization: Division of Endocrinology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado – sequence: 13 givenname: Adrah R. surname: Levin fullname: Levin, Adrah R. organization: Departments of Medicine and Academic Affairs – sequence: 14 givenname: Ashley surname: Frazer-Abel fullname: Frazer-Abel, Ashley organization: Complement Laboratory, National Jewish Health, Denver, Colorado – sequence: 15 givenname: Patricia C. surname: Giclas fullname: Giclas, Patricia C. organization: Complement Laboratory, National Jewish Health, Denver, Colorado – sequence: 16 givenname: Judith surname: Korner fullname: Korner, Judith organization: Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York – sequence: 17 givenname: Michael D. surname: Iseman fullname: Iseman, Michael D. organization: Division of Infectious Diseases, Division of Pulmonary Sciences and Critical Care Medicine, and, Departments of Medicine and Academic Affairs – sequence: 18 givenname: Leland surname: Shapiro fullname: Shapiro, Leland organization: Division of Infectious Diseases, Denver Veterans Affairs Medical Center, Denver, Colorado – sequence: 19 givenname: Edward D. surname: Chan fullname: Chan, Edward D. organization: Division of Pulmonary Sciences and Critical Care Medicine, and, Departments of Medicine and Academic Affairs, Denver Veterans Affairs Medical Center, Denver, Colorado |
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| Copyright | 2014 INIST-CNRS Copyright American Thoracic Society Jan 15, 2013 Copyright © 2013 by the American Thoracic Society |
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| Keywords | adiponectin Skin disease Intensive care Deformation Spine Diseases of the osteoarticular system Spine disease Mycobacterial infection Marfan syndrome Osteoarticular system Scoliosis Systemic disease Chest wall Resuscitation Human Connective tissue disease Lung disease Elastic tissue disease Respiratory disease Congenital disease Genetic disease Infection Phenotype Malformation Leptin Bacteriosis Pectus excavatum |
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| References | Iseman MD (bib14) 1998; 109 bib36 bib37 bib32 bib33 bib30 bib31 bib29 Kartalija M (bib35) 2011; 183 bib27 bib28 Palmer CE (bib10) 1957; 76 bib40 Pyeritz RE (bib62) 1988; 43 bib48 Carlson GL (bib54) 1999; 276 bib45 bib46 bib43 bib44 bib41 bib42 bib9 bib7 bib8 bib5 bib6 bib3 bib38 bib4 bib39 bib1 bib2 bib50 Champsi J (bib47) 1995; 84 bib58 bib15 bib59 bib56 bib13 bib57 Fantuzzi G (bib19) 2000; 68 bib55 bib52 Tverdal A (bib12) 1986; 69 bib53 bib49 Tverdal A (bib11) 1988; 63 Chan ED (bib34) 2012; 185 Faggioni R (bib51) 1998; 274 bib61 bib60 bib25 bib26 bib23 bib24 bib21 bib22 bib63 bib20 bib18 bib16 bib17 |
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| SubjectTerms | Adipokines - blood Adipose Tissue - physiology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Body fat Body Mass Index Case-Control Studies Chronic obstructive pulmonary disease Cytokines Cytokines - blood Disease Susceptibility - blood Disease Susceptibility - immunology Drug toxicity and drugs side effects treatment Female Funnel Chest - complications Gender Habitus Health care Humans Intensive care medicine Lung diseases Male Medical sciences Middle Aged Mycobacterium Infections, Nontuberculous - etiology Mycobacterium Infections, Nontuberculous - immunology Pharmacology. Drug treatments Phenotype Scoliosis Scoliosis - complications Toxicity: blood Tuberculosis Tumor necrosis factor-TNF Womens health |
| Title | Patients with Nontuberculous Mycobacterial Lung Disease Exhibit Unique Body and Immune Phenotypes |
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