Activation of mammalian target of rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma

BACKGROUND: Dysregulation of the mammalian target of rapamycin (mTOR) pathway has been shown to contribute to tumorigenesis. This study explored protein expression profiles of mTOR pathway and the relationship with prognosis in patients with nonsmall cell lung carcinoma (NSCLC). METHODS: The protein...

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Vydané v:	Cancer Ročník 117; číslo 16; s. 3763 - 3773
Hlavní autori:	Liu, Dan, Huang, Yi, Chen, Bojiang, Zeng, Jing, Guo, Na, Zhang, Shangfu, Liu, Lunxu, Xu, Hong, Mo, Xianming, Li, Weimin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.08.2011 Wiley-Blackwell
Predmet:	activated kinases Biological and medical sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Female Humans Lung Neoplasms - metabolism Lung Neoplasms - mortality Male mammalian target of rapamycin pathway Medical sciences Middle Aged nonsmall cell lung carcinoma Phosphorylation Phosphotransferases - metabolism Pneumology Prognosis Protein Array Analysis protein expression profiles Signal Transduction TOR Serine-Threonine Kinases - metabolism Tumors Tumors of the respiratory system and mediastinum Lung disease Prognosis Enzyme Respiratory disease Transferases Lung cancer Malignant tumor Bronchopulmonary carcinoma Cancerology Kinase Mammalian target of rapamycin protein-expression profiles Bronchus disease Complication activated kinases mammalian target of rapamycin pathway nonsmall cell lung carcinoma Cancer
ISSN:	0008-543X, 1097-0142, 1097-0142
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