Just 2% of SARS-CoV-2-positive individuals carry 90% of the virus circulating in communities

We analyze data from the fall 2020 pandemic response efforts at the University of Colorado Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using qRT-PCR. All samples were collected from individuals who reported no symptoms a...

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Vydáno v:Proceedings of the National Academy of Sciences - PNAS Ročník 118; číslo 21
Hlavní autoři: Yang, Qing, Saldi, Tassa K, Gonzales, Patrick K, Lasda, Erika, Decker, Carolyn J, Tat, Kimngan L, Fink, Morgan R, Hager, Cole R, Davis, Jack C, Ozeroff, Christopher D, Muhlrad, Denise, Clark, Stephen K, Fattor, Will T, Meyerson, Nicholas R, Paige, Camille L, Gilchrist, Alison R, Barbachano-Guerrero, Arturo, Worden-Sapper, Emma R, Wu, Sharon S, Brisson, Gloria R, McQueen, Matthew B, Dowell, Robin D, Leinwand, Leslie, Parker, Roy, Sawyer, Sara L
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 25.05.2021
Témata:
Asymptomatic Infections - epidemiology
Carrier State - diagnosis
Carrier State - epidemiology
Carrier State - transmission
Carrier State - virology
Colorado - epidemiology
COVID-19 - diagnosis
COVID-19 - epidemiology
COVID-19 - transmission
COVID-19 - virology
Hospitalization - statistics & numerical data
Humans
Mass Screening - statistics & numerical data
Saliva - virology
SARS-CoV-2 - genetics
SARS-CoV-2 - isolation & purification
Universities
Viral Load
Virion
Colorado
SARS-CoV-2
transmission
viral load
ISSN:1091-6490, 1091-6490
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Shrnutí:We analyze data from the fall 2020 pandemic response efforts at the University of Colorado Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using qRT-PCR. All samples were collected from individuals who reported no symptoms associated with COVID-19 on the day of collection. From these, 1,405 positive cases were identified. The distribution of viral loads within these asymptomatic individuals was indistinguishable from what has been previously observed in symptomatic individuals. Regardless of symptomatic status, ∼50% of individuals who test positive for SARS-CoV-2 seem to be in noninfectious phases of the disease, based on having low viral loads in a range from which live virus has rarely been isolated. We find that, at any given time, just 2% of individuals carry 90% of the virions circulating within communities, serving as viral "supercarriers" and possibly also superspreaders.
Bibliografie:ObjectType-Article-1
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.2104547118