Inorganic Polyphosphate Amplifies High Mobility Group Box 1-Mediated Von Willebrand Factor Release and Platelet String Formation on Endothelial Cells

Objective- Inorganic polyphosphate (polyP) is known to modulate coagulation, inflammation, and metabolic pathways. It also amplifies inflammatory responses of HMGB1 (high mobility group box 1) in endothelial cells. The objective of this study was to evaluate the effect of polyP on von Willebrand fac...

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Bibliographic Details
Published in:	Arteriosclerosis, thrombosis, and vascular biology Vol. 38; no. 8; p. 1868
Main Authors:	Biswas, Indranil, Panicker, Sumith R, Cai, Xiaofeng, Mehta-D'souza, Padmaja, Rezaie, Alireza R
Format:	Journal Article
Language:	English
Published:	United States 01.08.2018
Subjects:	Blood Coagulation - drug effects Blood Platelets - drug effects Blood Platelets - metabolism Calcium Signaling - drug effects Cell Line Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism HMGB1 Protein - pharmacology Humans Inflammation Mediators - metabolism Phosphates - toxicity Phosphorylation Platelet Adhesiveness - drug effects Polyphosphates - toxicity Receptor for Advanced Glycation End Products - genetics Receptor for Advanced Glycation End Products - metabolism Receptors, Purinergic P2Y1 - genetics Receptors, Purinergic P2Y1 - metabolism Secretory Pathway src-Family Kinases - metabolism Type C Phospholipases - metabolism von Willebrand Factor - metabolism angiopoietin-2 blood platelets endothelial cells advanced glycation end products von Willebrand factor
ISSN:	1524-4636, 1524-4636
Online Access:	Get more information
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