Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds

Several disulfide-based and azoic compounds have shown antiviral and virucidal properties against arenaviruses in virus yield-inhibition and inactivation assays, respectively. The most effective virucidal agent, the aromatic disulfide NSC20625, was able to inactivate two strains of the prototype are...

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Bibliographic Details
Published in:	Journal of general virology Vol. 87; no. Pt 5; p. 1217
Main Authors:	García, Cybele C, Djavani, Mahmoud, Topisirovic, Ivan, Borden, Katherine L B, Salvato, María S, Damonte, Elsa B
Format:	Journal Article
Language:	English
Published:	England 01.05.2006
Subjects:	Animals Azo Compounds - chemistry Azo Compounds - pharmacology Carrier Proteins - drug effects Cell Line Disulfides - chemistry Disulfides - pharmacology Humans Intracellular Signaling Peptides and Proteins Lymphocytic choriomeningitis virus - drug effects Lymphocytic choriomeningitis virus - physiology Oligodeoxyribonucleotides - metabolism RNA, Viral - biosynthesis RNA, Viral - drug effects Virus Replication - drug effects Zinc Fingers - drug effects
ISSN:	0022-1317
Online Access:	Get more information
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