Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study

Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and re...

Full description

Saved in:
Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry Vol. 112; p. 110428
Main Authors: Sharma, Anuradha, Ren, Xinguo, Zhang, Hui, Pandey, Ghanshyam N.
Format: Journal Article
Language:English
Published: England Elsevier Inc 10.01.2022
Subjects:
Adult
Autopsy
Depression
Depression - physiopathology
Female
Hippocampus
Humans
Male
Neuropeptide Y
Neuropeptide Y - physiology
Prefrontal Cortex
Receptors, Neuropeptide Y - physiology
RNA, Messenger - metabolism
Stress, Psychological - physiopathology
Suicide
Neuropeptide Y
Depression
Prefrontal cortex
Suicide
Hippocampus
ISSN:0278-5846, 1878-4216, 1878-4216
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n = 24) and depressed suicide (DS) (n = 24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression. •Neuropeptide Y (NPY) plays a major role in stress response and may have antidepressant-like effect.•Abnormalities of NPY and its receptors may be present in depression and suicide.•NPY mRNA and protein expression was decreased in postmortem brain of depressed suicide subjects.•mRNA expression of NPY1R and NPY2R was increased in postmortem brain of depressed suicide subjects.•Our results show NPY abnormalities in postmortem brain of depressed suicide subjects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Study concept and design: GNP; protein analysis: XR; mRNA analysis: AS and HZ; analysis and interpretation of data: GNP and AS; literature review for the paper: AS, GNP, XR, and HZ; drafting of the manuscript: AS and GNP. All authors contributed to and edited the final manuscript. All authors have read and approved the submitted version of the paper and agreed to be accountable for all aspects of the work.
Contribution of authors
ISSN:0278-5846
1878-4216
1878-4216
DOI:10.1016/j.pnpbp.2021.110428