Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study

Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and re...

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Vydané v:	Progress in neuro-psychopharmacology & biological psychiatry Ročník 112; s. 110428
Hlavní autori:	Sharma, Anuradha, Ren, Xinguo, Zhang, Hui, Pandey, Ghanshyam N.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Inc 10.01.2022
Predmet:	Adult Autopsy Depression Depression - physiopathology Female Hippocampus Humans Male Neuropeptide Y Neuropeptide Y - physiology Prefrontal Cortex Receptors, Neuropeptide Y - physiology RNA, Messenger - metabolism Stress, Psychological - physiopathology Suicide Neuropeptide Y Depression Prefrontal cortex Suicide Hippocampus
ISSN:	0278-5846, 1878-4216, 1878-4216
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Abstract	Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n = 24) and depressed suicide (DS) (n = 24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression. •Neuropeptide Y (NPY) plays a major role in stress response and may have antidepressant-like effect.•Abnormalities of NPY and its receptors may be present in depression and suicide.•NPY mRNA and protein expression was decreased in postmortem brain of depressed suicide subjects.•mRNA expression of NPY1R and NPY2R was increased in postmortem brain of depressed suicide subjects.•Our results show NPY abnormalities in postmortem brain of depressed suicide subjects.
AbstractList	Neuropeptides are small proteinaceous molecules (3-100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n = 24) and depressed suicide (DS) (n = 24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression. Neuropeptides are small proteinaceous molecules (3-100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n = 24) and depressed suicide (DS) (n = 24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression.Neuropeptides are small proteinaceous molecules (3-100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n = 24) and depressed suicide (DS) (n = 24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression. Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n=24) and depressed suicide (DS) (n=24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression. Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide Y (NPY), a highly conserved and expressed neuropeptide in the central nervous system of mammals, plays a major role in stress response and resilience. Increasing evidence suggests that NPY and its receptors are altered in depression and suicide, pointing to their antidepressant-like nature. The objective of this study was to examine the role of NPY system in depression and suicidal behavior. Expression of NPY and its four receptors, NPY1R, NPY2R, NPY4R, and NPY5R was studied at the transcriptional and translational levels in the prefrontal cortex (PFC) and hippocampus regions of the postmortem brain of normal control (NC) (n = 24) and depressed suicide (DS) (n = 24) subjects. We observed a significant decrease in NPY mRNA and upregulation in NPY1R and NPY2R mRNA in both brain regions of DS subjects compared with NC subjects. We also observed a significant decrease in NPY protein expression in the PFC of subjects with DS. This study provides the first detailed evidence of alterations in the NPY system and the associated stress response in depression and suicidal behavior in humans. The outcomes of this study could be applied in the development of novel NPY system-targeted approaches for the treatment of depression. •Neuropeptide Y (NPY) plays a major role in stress response and may have antidepressant-like effect.•Abnormalities of NPY and its receptors may be present in depression and suicide.•NPY mRNA and protein expression was decreased in postmortem brain of depressed suicide subjects.•mRNA expression of NPY1R and NPY2R was increased in postmortem brain of depressed suicide subjects.•Our results show NPY abnormalities in postmortem brain of depressed suicide subjects.
ArticleNumber	110428
Author	Ren, Xinguo Zhang, Hui Sharma, Anuradha Pandey, Ghanshyam N.
Author_xml	– sequence: 1 givenname: Anuradha surname: Sharma fullname: Sharma, Anuradha – sequence: 2 givenname: Xinguo surname: Ren fullname: Ren, Xinguo – sequence: 3 givenname: Hui surname: Zhang fullname: Zhang, Hui – sequence: 4 givenname: Ghanshyam N. surname: Pandey fullname: Pandey, Ghanshyam N. email: Gnpandey@uic.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34411658$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1016/S0924-8196(00)80011-1 10.1016/S0304-3940(99)00234-7 10.1002/(SICI)1520-6394(1997)6:1<1::AID-DA1>3.0.CO;2-J 10.1016/S0893-133X(00)00159-7 10.1002/jnr.20200 10.1177/0269881109104851 10.1016/S0149-7634(01)00066-5 10.2147/NDT.S219962 10.1016/0014-2999(88)90182-3 10.1016/j.brainres.2006.04.026 10.1371/journal.pone.0191794 10.1093/ijnp/pyaa054 10.1517/14728222.2011.628314 10.1016/0304-3940(96)13008-1 10.1073/pnas.220232997 10.1016/S0022-3956(03)00101-8 10.1002/ddr.20031 10.1016/j.npep.2004.05.006 10.1016/S0014-2999(01)00768-3 10.1097/00008877-199504000-00001 10.1016/j.npep.2019.102001 10.1016/j.npep.2017.01.004 10.1055/s-0035-1565241 10.1016/j.euroneuro.2014.10.006 10.1677/JOE-07-0634 10.1111/j.1476-5381.2012.01872.x 10.1016/0166-2236(94)90079-5 10.1002/depr.3050030505 10.1038/s41586-018-0046-x 10.1016/0196-9781(96)00013-7 10.1038/mp.2012.101 10.1155/2013/687575 10.1016/j.neuroscience.2008.11.048 10.3389/fnbeh.2018.00159 10.1016/j.brainres.2011.05.033 10.1111/j.1471-4159.1992.tb08877.x 10.1016/S0166-4328(02)00374-1 10.1016/j.npep.2015.09.008 10.1006/bbrc.2000.3656 10.1007/BF00441953 10.1016/S0165-0327(97)00197-3 10.1016/S1567-133X(01)00003-5 10.1016/S0196-9781(97)00298-2 10.1017/S1461145711001556 10.1016/S0893-133X(02)00363-9 10.1016/j.euroneuro.2004.01.005 10.1016/j.psyneuen.2013.06.020 10.1093/ijnp/pyx109 10.1016/j.jchemneu.2009.05.009 10.1007/s00441-006-0268-3 10.1016/S0091-3057(01)00679-7 10.1002/da.20876 10.1016/S0165-3806(01)00264-4 10.3389/fendo.2013.00005 10.1093/ijnp/pyu023 10.1016/S0028-3908(02)00234-4 10.1007/s00213-007-0945-2 10.1037/ccp0000451 10.1016/S0924-977X(98)00026-1 10.1016/j.brainres.2009.09.077 10.1016/S0893-133X(00)00231-1 10.1176/ajp.156.12.1895 10.1016/j.bbi.2018.09.024 10.1002/jnr.24614
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Keywords	Neuropeptide Y Depression Prefrontal cortex Suicide Hippocampus
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Study concept and design: GNP; protein analysis: XR; mRNA analysis: AS and HZ; analysis and interpretation of data: GNP and AS; literature review for the paper: AS, GNP, XR, and HZ; drafting of the manuscript: AS and GNP. All authors contributed to and edited the final manuscript. All authors have read and approved the submitted version of the paper and agreed to be accountable for all aspects of the work. Contribution of authors
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References	Widdowson, Ordway, Halaris (bb0335) 1992; 59 Schmidt, Liebl, Sterlemann, Ganea, Hartmann, Harbich, Alam, Muller (bb0265) 2008; 197 Husum, Mathe (bb0080) 2002; 27 Nikisch, Baumann, Liu, Mathe (bb0160) 2012; 15 Pandey, Rizavi, Bhaumik, Ren (bb0200) 2019; 75 Alvina, Jodeiri Farshbaf, Mondal (bb0005) 2021; 99 Sajdyk, Schober, Smiley, Gehlert (bb0240) 2002; 71 Nwokafor, Serova, Nahvi, McCloskey, Sabban (bb0170) 2020; 80 Holsboer (bb0070) 2000; 23 Painsipp, Sperk, Herzog, Holzer (bb0185) 2010; 24 Mathe, Michaneck, Berg, Charney, Murrough (bb0125) 2020; 23 First, Spitzer, Gibbon, Williams (bb0040) 1997 Westrin, Ekman, Traskman-Bendz (bb0325) 1999; 9 Soleimani, Oquendo, Sullivan, Mathe, Mann (bb0275) 2014; 18 Kask, Harro, von Horsten, Redrobe, Dumont, Quirion (bb0100) 2002; 26 Ozsoy, Olguner Eker, Abdulrezzak (bb0180) 2016; 49 Hou, Jia, Liu, Li (bb0075) 2006; 1095 Pandey, Rizavi, Ren, Dwivedi, Palkovits (bb0195) 2013; 38 Westrin, Engstom, Ekman, Traskman-Bendz (bb0320) 1998; 49 Sajdyk, Schober, Gehlert (bb0235) 2002; 43 Caberlotto, Hurd (bb0015) 2001; 25 Sah, Geracioti (bb0225) 2013; 18 Yang, Han, Keller, Kaiser, Bender, Bosse, Burkert, Kogler, Wifling, Bernhardt, Plank, Littmann, Schmidt, Yi, Li, Ye, Zhang, Xu, Larhammar, Stevens, Huster, Meiler, Zhao, Beck-Sickinger, Buschauer, Wu (bb0345) 2018; 556 Morales-Medina, Sanchez, Flores, Dumont, Quirion (bb0145) 2009; 38 Heilig, Zachrisson, Thorsell, Ehnvall, Mottagui-Tabar, Sjogren, Asberg, Ekman, Wahlestedt, Agren (bb0065) 2004; 38 Hashimoto, Onishi, Koide, Kai, Yamagami (bb0045) 1996; 216 Mathe, Rudorfer, Stenfors, Manji, Potter, Theodorsson (bb0120) 1995; 3 Sajdyk (bb0230) 2005; 65 Heilig, Wahlestedt, Ekman, Widerlov (bb0050) 1988; 147 Caberlotto, Jimenez, Overstreet, Hurd, Mathe, Fuxe (bb0020) 1999; 265 Heilig, Soderpalm, Engel, Widerlov (bb0055) 1989; 98 Martinez, Garakani, Yehuda, Gorman (bb0115) 2012; 29 Morales-Medina, Dumont, Quirion (bb0150) 2010; 1314 Tasan, Lin, Hetzenauer, Singewald, Herzog, Sperk (bb0290) 2009; 158 Redrobe, Dumont, Herzog, Quirion (bb0215) 2003; 141 Crespi (bb0025) 2011; 1407 Jimenez-Vasquez, Mathe, Thomas, Riley, Ehlers (bb0085) 2001; 131 Sajdyk, Shekhar, Gehlert (bb0245) 2004; 38 Meriney, Fanselow (bb0130) 2019 Karlsson, Choe, Cameron, Thorsell, Crawley, Holmes, Heilig (bb0090) 2008; 195 Heilig, Koob, Ekman, Britton (bb0060) 1994; 17 Broqua, Wettstein, Rocher, Gauthier-Martin, Junien (bb0010) 1995; 6 Sayed, Van Dam, Horn, Kautz, Parides, Costi, Collins, Iacoviello, Iosifescu, Mathe, Southwick, Feder, Charney, Murrough (bb0260) 2018; 21 Pedragosa-Badia, Stichel, Beck-Sickinger (bb0205) 2013; 4 Pandey, Dwivedi, Pandey, Teas, Conley, Roberts, Tamminga (bb0190) 1999; 156 Qi, Kim, Sanchez, Ziaee, Kohtz, Koh (bb0210) 2018; 13 Webb, Cohen, Beard, Forgeard, Peckham, Bjorgvinsson (bb0315) 2020; 88 Nakajima, Inui, Asakawa, Momose, Ueno, Teranishi, Baba, Kasuga (bb0155) 1998; 19 Lu, Li, Li, Mou, Zhou, Huang, Huang, Xu (bb0110) 2019; 15 Serafini, Pompili, Lindqvist, Dwivedi, Girardi (bb0270) 2013; 2013 Wahlestedt, Heilig (bb0305) 1995 Dumont, Jacques, St-Pierre, Tong, Parker, Herzog, Quirion (bb0030) 2000 Kuromitsu, Yokoi, Kawai, Nagasu, Aizawa, Haga, Ikeda (bb0105) 2001; 1 Olsson, Regnell, Traskman-Bendz, Ekman, Westrin (bb0175) 2004; 14 Millon, Flores-Burgess, Narvaez, Borroto-Escuela, Gago, Santin, Castilla-Ortega, Narvaez, Fuxe, Diaz-Cabiale (bb0135) 2017; 64 Sorensen, Lindberg, Wortwein, Bolwig, Woldbye (bb0280) 2004; 77 Kask, Vasar, Heidmets, Allikmets, Wikberg (bb0095) 2001; 414 Ehlers, Somes, Seifritz, Rivier (bb0035) 1997; 6 Verma, Tasan, Herzog, Sperk (bb0300) 2012; 166 Reichmann, Holzer (bb0220) 2016; 55 Salio, Lossi, Ferrini, Merighi (bb0250) 2006; 326 Thorsell, Michalkiewicz, Dumont, Quirion, Caberlotto, Rimondini, Mathe, Heilig (bb0295) 2000; 97 Sandberg, Jakobsson, Palsson, Landen, Mathe (bb0255) 2014; 24 Wang, Xu, Chen, Dong, Du, Sun, Shi, Li, Yang, Li, Xu (bb0310) 2019 Nilsson, Karlsson, Blennow, Heilig, Ekman (bb0165) 1996; 17 WHO (bb0330) 2017 Miragaia, de Oliveira Wertheimer, Consoli, Cabbia, Longo, Girardi, Suchecki (bb0140) 2018; 12 Starback, Wraith, Eriksson, Larhammar (bb0285) 2000; 277 Wu, Feder, Wegener, Bailey, Saxena, Charney, Mathe (bb0340) 2011; 15 Martinez (10.1016/j.pnpbp.2021.110428_bb0115) 2012; 29 Sah (10.1016/j.pnpbp.2021.110428_bb0225) 2013; 18 Heilig (10.1016/j.pnpbp.2021.110428_bb0055) 1989; 98 Wahlestedt (10.1016/j.pnpbp.2021.110428_bb0305) 1995 Nakajima (10.1016/j.pnpbp.2021.110428_bb0155) 1998; 19 Thorsell (10.1016/j.pnpbp.2021.110428_bb0295) 2000; 97 Meriney (10.1016/j.pnpbp.2021.110428_bb0130) 2019 Mathe (10.1016/j.pnpbp.2021.110428_bb0125) 2020; 23 Dumont (10.1016/j.pnpbp.2021.110428_bb0030) 2000 Pedragosa-Badia (10.1016/j.pnpbp.2021.110428_bb0205) 2013; 4 Jimenez-Vasquez (10.1016/j.pnpbp.2021.110428_bb0085) 2001; 131 Lu (10.1016/j.pnpbp.2021.110428_bb0110) 2019; 15 Morales-Medina (10.1016/j.pnpbp.2021.110428_bb0145) 2009; 38 Ehlers (10.1016/j.pnpbp.2021.110428_bb0035) 1997; 6 Westrin (10.1016/j.pnpbp.2021.110428_bb0325) 1999; 9 Alvina (10.1016/j.pnpbp.2021.110428_bb0005) 2021; 99 Olsson (10.1016/j.pnpbp.2021.110428_bb0175) 2004; 14 Pandey (10.1016/j.pnpbp.2021.110428_bb0200) 2019; 75 Millon (10.1016/j.pnpbp.2021.110428_bb0135) 2017; 64 Qi (10.1016/j.pnpbp.2021.110428_bb0210) 2018; 13 Webb (10.1016/j.pnpbp.2021.110428_bb0315) 2020; 88 Sandberg (10.1016/j.pnpbp.2021.110428_bb0255) 2014; 24 Serafini (10.1016/j.pnpbp.2021.110428_bb0270) 2013; 2013 Miragaia (10.1016/j.pnpbp.2021.110428_bb0140) 2018; 12 Reichmann (10.1016/j.pnpbp.2021.110428_bb0220) 2016; 55 Heilig (10.1016/j.pnpbp.2021.110428_bb0050) 1988; 147 Heilig (10.1016/j.pnpbp.2021.110428_bb0060) 1994; 17 Wang (10.1016/j.pnpbp.2021.110428_bb0310) 2019 Sajdyk (10.1016/j.pnpbp.2021.110428_bb0245) 2004; 38 Schmidt (10.1016/j.pnpbp.2021.110428_bb0265) 2008; 197 First (10.1016/j.pnpbp.2021.110428_bb0040) 1997 Sorensen (10.1016/j.pnpbp.2021.110428_bb0280) 2004; 77 Widdowson (10.1016/j.pnpbp.2021.110428_bb0335) 1992; 59 Morales-Medina (10.1016/j.pnpbp.2021.110428_bb0150) 2010; 1314 Starback (10.1016/j.pnpbp.2021.110428_bb0285) 2000; 277 Kuromitsu (10.1016/j.pnpbp.2021.110428_bb0105) 2001; 1 Yang (10.1016/j.pnpbp.2021.110428_bb0345) 2018; 556 Heilig (10.1016/j.pnpbp.2021.110428_bb0065) 2004; 38 Sajdyk (10.1016/j.pnpbp.2021.110428_bb0235) 2002; 43 Hou (10.1016/j.pnpbp.2021.110428_bb0075) 2006; 1095 Mathe (10.1016/j.pnpbp.2021.110428_bb0120) 1995; 3 Nwokafor (10.1016/j.pnpbp.2021.110428_bb0170) 2020; 80 Nikisch (10.1016/j.pnpbp.2021.110428_bb0160) 2012; 15 Karlsson (10.1016/j.pnpbp.2021.110428_bb0090) 2008; 195 WHO (10.1016/j.pnpbp.2021.110428_bb0330) 2017 Husum (10.1016/j.pnpbp.2021.110428_bb0080) 2002; 27 Ozsoy (10.1016/j.pnpbp.2021.110428_bb0180) 2016; 49 Kask (10.1016/j.pnpbp.2021.110428_bb0100) 2002; 26 Caberlotto (10.1016/j.pnpbp.2021.110428_bb0020) 1999; 265 Sajdyk (10.1016/j.pnpbp.2021.110428_bb0230) 2005; 65 Wu (10.1016/j.pnpbp.2021.110428_bb0340) 2011; 15 Salio (10.1016/j.pnpbp.2021.110428_bb0250) 2006; 326 Kask (10.1016/j.pnpbp.2021.110428_bb0095) 2001; 414 Verma (10.1016/j.pnpbp.2021.110428_bb0300) 2012; 166 Broqua (10.1016/j.pnpbp.2021.110428_bb0010) 1995; 6 Soleimani (10.1016/j.pnpbp.2021.110428_bb0275) 2014; 18 Nilsson (10.1016/j.pnpbp.2021.110428_bb0165) 1996; 17 Pandey (10.1016/j.pnpbp.2021.110428_bb0195) 2013; 38 Crespi (10.1016/j.pnpbp.2021.110428_bb0025) 2011; 1407 Redrobe (10.1016/j.pnpbp.2021.110428_bb0215) 2003; 141 Westrin (10.1016/j.pnpbp.2021.110428_bb0320) 1998; 49 Sayed (10.1016/j.pnpbp.2021.110428_bb0260) 2018; 21 Holsboer (10.1016/j.pnpbp.2021.110428_bb0070) 2000; 23 Caberlotto (10.1016/j.pnpbp.2021.110428_bb0015) 2001; 25 Sajdyk (10.1016/j.pnpbp.2021.110428_bb0240) 2002; 71 Pandey (10.1016/j.pnpbp.2021.110428_bb0190) 1999; 156 Tasan (10.1016/j.pnpbp.2021.110428_bb0290) 2009; 158 Painsipp (10.1016/j.pnpbp.2021.110428_bb0185) 2010; 24 Hashimoto (10.1016/j.pnpbp.2021.110428_bb0045) 1996; 216
References_xml	– volume: 75 start-page: 101 year: 2019 end-page: 111 ident: bb0200 article-title: Innate immunity in the postmortem brain of depressed and suicide subjects: role of toll-like receptors publication-title: Brain Behav. Immun. – volume: 27 start-page: 756 year: 2002 end-page: 764 ident: bb0080 article-title: Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain. Lithium treatment modifies these changes publication-title: Neuropsychopharmacology – volume: 15 start-page: 2893 year: 2019 end-page: 2900 ident: bb0110 article-title: Changes in plasma NPY, IL-1beta and hypocretin in people who died by suicide publication-title: Neuropsychiatr Dis Treat – volume: 24 start-page: 1541 year: 2010 end-page: 1549 ident: bb0185 article-title: Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice publication-title: J. Psychopharmacol. – volume: 6 start-page: 1 year: 1997 end-page: 9 ident: bb0035 article-title: CRF/NPY interactions: a potential role in sleep dysregulation in depression and anxiety publication-title: Depress. Anxiety – volume: 55 start-page: 99 year: 2016 end-page: 109 ident: bb0220 article-title: Neuropeptide Y: a stressful review publication-title: Neuropeptides – year: 2017 ident: bb0330 article-title: Depression and Other Common Mental Disorders – volume: 17 start-page: 80 year: 1994 end-page: 85 ident: bb0060 article-title: Corticotropin-releasing factor and neuropeptide Y: role in emotional integration publication-title: Trends Neurosci. – volume: 326 start-page: 583 year: 2006 end-page: 598 ident: bb0250 article-title: Neuropeptides as synaptic transmitters publication-title: Cell Tissue Res. – start-page: 375 year: 2000 end-page: 475 ident: bb0030 article-title: Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brains publication-title: Handbook of Chemical Neuroanatomy – volume: 1407 start-page: 27 year: 2011 end-page: 37 ident: bb0025 article-title: Influence of neuropeptide Y and antidepressants upon cerebral monoamines involved in depression: an in vivo electrochemical study publication-title: Brain Res. – year: 1997 ident: bb0040 article-title: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) – volume: 71 start-page: 419 year: 2002 end-page: 423 ident: bb0240 article-title: Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala publication-title: Pharmacol. Biochem. Behav. – volume: 38 start-page: 2628 year: 2013 end-page: 2639 ident: bb0195 article-title: Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims publication-title: Psychoneuroendocrinology – volume: 25 start-page: 91 year: 2001 end-page: 97 ident: bb0015 article-title: Neuropeptide Y Y(1) and Y(2) receptor mRNA expression in the prefrontal cortex of psychiatric subjects. Relationship of Y(2) subtype to suicidal behavior publication-title: Neuropsychopharmacology – volume: 1314 start-page: 194 year: 2010 end-page: 205 ident: bb0150 article-title: A possible role of neuropeptide Y in depression and stress publication-title: Brain Res. – volume: 21 start-page: 3 year: 2018 end-page: 11 ident: bb0260 article-title: A randomized dose-ranging study of neuropeptide Y in patients with posttraumatic stress disorder publication-title: Int. J. Neuropsychopharmacol. – volume: 88 start-page: 25 year: 2020 end-page: 38 ident: bb0315 article-title: Personalized prognostic prediction of treatment outcome for depressed patients in a naturalistic psychiatric hospital setting: a comparison of machine learning approaches publication-title: J. Consult. Clin. Psychol. – volume: 15 start-page: 1317 year: 2011 end-page: 1331 ident: bb0340 article-title: Central functions of neuropeptide Y in mood and anxiety disorders publication-title: Expert Opin. Ther. Targets – volume: 265 start-page: 191 year: 1999 end-page: 194 ident: bb0020 article-title: Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders sensitive line rats, a genetic animal model of depression publication-title: Neurosci. Lett. – volume: 147 start-page: 465 year: 1988 end-page: 467 ident: bb0050 article-title: Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain publication-title: Eur. J. Pharmacol. – volume: 156 start-page: 1895 year: 1999 end-page: 1901 ident: bb0190 article-title: Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta1 protein in the prefrontal cortex of teenage suicide subjects publication-title: Am. J. Psychiatry – volume: 1 start-page: 17 year: 2001 end-page: 21 ident: bb0105 article-title: Reduced neuropeptide Y mRNA levels in the frontal cortex of people with schizophrenia and bipolar disorder publication-title: Brain Res. Gene Expr. Patterns – volume: 43 start-page: 1165 year: 2002 end-page: 1172 ident: bb0235 article-title: Neuropeptide Y receptor subtypes in the basolateral nucleus of the amygdala modulate anxiogenic responses in rats publication-title: Neuropharmacology – volume: 99 start-page: 57 year: 2021 end-page: 66 ident: bb0005 article-title: Long term effects of stress on hippocampal function: emphasis on early life stress paradigms and potential involvement of neuropeptide Y publication-title: J. Neurosci. Res. – volume: 18 start-page: 646 year: 2013 end-page: 655 ident: bb0225 article-title: Neuropeptide Y and posttraumatic stress disorder publication-title: Mol. Psychiatry – volume: 18 year: 2014 ident: bb0275 article-title: Cerebrospinal fluid neuropeptide Y levels in major depression and reported childhood trauma publication-title: Int. J. Neuropsychopharmacol. – volume: 414 start-page: 215 year: 2001 end-page: 224 ident: bb0095 article-title: Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat publication-title: Eur. J. Pharmacol. – volume: 197 start-page: 421 year: 2008 end-page: 427 ident: bb0265 article-title: Neuropeptide Y mediates the initial hypothalamic-pituitary-adrenal response to maternal separation in the neonatal mouse publication-title: J. Endocrinol. – volume: 38 start-page: 225 year: 2004 end-page: 234 ident: bb0245 article-title: Interactions between NPY and CRF in the amygdala to regulate emotionality publication-title: Neuropeptides – start-page: 421 year: 2019 end-page: 434 ident: bb0130 article-title: Neuropeptide transmitters publication-title: Synaptic Transmission – volume: 64 start-page: 39 year: 2017 end-page: 45 ident: bb0135 article-title: The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours publication-title: Neuropeptides – year: 2019 ident: bb0310 article-title: NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway publication-title: Mediat. Inflamm. – volume: 6 start-page: 215 year: 1995 end-page: 222 ident: bb0010 article-title: Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures publication-title: Behav. Pharmacol. – volume: 15 start-page: 1051 year: 2012 end-page: 1061 ident: bb0160 article-title: Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response publication-title: Int. J. Neuropsychopharmacol. – volume: 29 start-page: 32 year: 2012 end-page: 38 ident: bb0115 article-title: Proinflammatory and “resiliency” proteins in the CSF of patients with major depression publication-title: Depress Anxiety – volume: 141 start-page: 251 year: 2003 end-page: 255 ident: bb0215 article-title: Neuropeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety: evidence from Y2 receptor knockout mice publication-title: Behav. Brain Res. – volume: 38 start-page: 113 year: 2004 end-page: 121 ident: bb0065 article-title: Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism publication-title: J. Psychiatr. Res. – volume: 97 start-page: 12852 year: 2000 end-page: 12857 ident: bb0295 article-title: Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 9 start-page: 205 year: 1999 end-page: 211 ident: bb0325 article-title: Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt publication-title: Eur Neuropsychopharmacol – volume: 556 start-page: 520 year: 2018 end-page: 524 ident: bb0345 article-title: Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor publication-title: Nature – volume: 14 start-page: 479 year: 2004 end-page: 485 ident: bb0175 article-title: Cerebrospinal neuropeptide Y and substance P in suicide attempters during long-term antidepressant treatment publication-title: Eur. Neuropsychopharmacol. – volume: 19 start-page: 359 year: 1998 end-page: 363 ident: bb0155 article-title: Neuropeptide Y produces anxiety via Y2-type receptors publication-title: Peptides – volume: 65 start-page: 301 year: 2005 end-page: 308 ident: bb0230 article-title: Neuropeptide Y receptors as therapeutic targets in anxiety and depression publication-title: Drug Dev. Res. – volume: 4 start-page: 5 year: 2013 ident: bb0205 article-title: Neuropeptide Y receptors: how to get subtype selectivity publication-title: Front. Endocrinol. (Lausanne) – volume: 277 start-page: 264 year: 2000 end-page: 269 ident: bb0285 article-title: Neuropeptide Y receptor gene y6: multiple deaths or resurrections? publication-title: Biochem. Biophys. Res. Commun. – volume: 23 start-page: 477 year: 2000 end-page: 501 ident: bb0070 article-title: The corticosteroid receptor hypothesis of depression publication-title: Neuropsychopharmacology – volume: 23 start-page: 783 year: 2020 end-page: 790 ident: bb0125 article-title: A randomized controlled trial of intranasal neuropeptide Y in patients with major depressive disorder publication-title: Int. J. Neuropsychopharmacol. – volume: 24 start-page: 1907 year: 2014 end-page: 1915 ident: bb0255 article-title: Low neuropeptide Y in cerebrospinal fluid in bipolar patients is associated with previous and prospective suicide attempts publication-title: Eur. Neuropsychopharmacol. – start-page: 543 year: 1995 end-page: 552 ident: bb0305 article-title: Neuropeptide Y and related peptides publication-title: Psychopharmacology: A Fourth Generation of Progress – volume: 26 start-page: 259 year: 2002 end-page: 283 ident: bb0100 article-title: The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y publication-title: Neurosci. Biobehav. Rev. – volume: 166 start-page: 1461 year: 2012 end-page: 1473 ident: bb0300 article-title: NPY controls fear conditioning and fear extinction by combined action on Y(1) and Y(2) receptors publication-title: Br. J. Pharmacol. – volume: 98 start-page: 524 year: 1989 end-page: 529 ident: bb0055 article-title: Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models publication-title: Psychopharmacology – volume: 12 start-page: 159 year: 2018 ident: bb0140 article-title: Maternal deprivation increases anxiety- and depressive-like Behaviors in an age-dependent fashion and reduces neuropeptide Y expression in the amygdala and hippocampus of male and female young adult rats publication-title: Front. Behav. Neurosci. – volume: 158 start-page: 1717 year: 2009 end-page: 1730 ident: bb0290 article-title: Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice publication-title: Neuroscience – volume: 49 start-page: 45 year: 1998 end-page: 54 ident: bb0320 article-title: Correlations between plasma-neuropeptides and temperament dimensions differ between suicidal patients and healthy controls publication-title: J Affect Disord – volume: 49 start-page: 26 year: 2016 end-page: 31 ident: bb0180 article-title: The effects of antidepressants on neuropeptide Y in patients with depression and anxiety publication-title: Pharmacopsychiatry – volume: 59 start-page: 73 year: 1992 end-page: 80 ident: bb0335 article-title: Reduced neuropeptide Y concentrations in suicide brain publication-title: J. Neurochem. – volume: 1095 start-page: 154 year: 2006 end-page: 158 ident: bb0075 article-title: CSF serotonin, 5-hydroxyindolacetic acid and neuropeptide Y levels in severe major depressive disorder publication-title: Brain Res. – volume: 3 start-page: 250 year: 1995 end-page: 256 ident: bb0120 article-title: Effect of electroconvulsive treatmetn on somatostatin, neuropeptide Y, endothelin, and neurokinin a concentrations in cerebrospinal fluis of depressed patients: a pilot study publication-title: Depression – volume: 38 start-page: 266 year: 2009 end-page: 272 ident: bb0145 article-title: Morphological reorganization after repeated corticosterone administration in the hippocampus, nucleus accumbens and amygdala in the rat publication-title: J. Chem. Neuroanat. – volume: 2013 start-page: 687575 year: 2013 ident: bb0270 article-title: The role of neuropeptides in suicidal behavior: a systematic review publication-title: Biomed. Res. Int. – volume: 195 start-page: 547 year: 2008 end-page: 557 ident: bb0090 article-title: The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice publication-title: Psychopharmacology – volume: 17 start-page: 359 year: 1996 end-page: 362 ident: bb0165 article-title: Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients publication-title: Peptides – volume: 77 start-page: 723 year: 2004 end-page: 729 ident: bb0280 article-title: Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation publication-title: J. Neurosci. Res. – volume: 131 start-page: 149 year: 2001 end-page: 152 ident: bb0085 article-title: Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats publication-title: Brain Res. Dev. Brain Res. – volume: 13 year: 2018 ident: bb0210 article-title: Enhanced susceptibility to stress and seizures in GAD65 deficient mice publication-title: PLoS One – volume: 80 start-page: 102001 year: 2020 ident: bb0170 article-title: Activation of NPY receptor subtype 1 by [D-his(26)]NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD publication-title: Neuropeptides – volume: 216 start-page: 57 year: 1996 end-page: 60 ident: bb0045 article-title: Plasma neuropeptide Y in patients with major depressive disorder publication-title: Neurosci. Lett. – start-page: 375 year: 2000 ident: 10.1016/j.pnpbp.2021.110428_bb0030 article-title: Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brains doi: 10.1016/S0924-8196(00)80011-1 – volume: 265 start-page: 191 issue: 3 year: 1999 ident: 10.1016/j.pnpbp.2021.110428_bb0020 article-title: Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders sensitive line rats, a genetic animal model of depression publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(99)00234-7 – volume: 6 start-page: 1 issue: 1 year: 1997 ident: 10.1016/j.pnpbp.2021.110428_bb0035 article-title: CRF/NPY interactions: a potential role in sleep dysregulation in depression and anxiety publication-title: Depress. Anxiety doi: 10.1002/(SICI)1520-6394(1997)6:1<1::AID-DA1>3.0.CO;2-J – volume: 23 start-page: 477 issue: 5 year: 2000 ident: 10.1016/j.pnpbp.2021.110428_bb0070 article-title: The corticosteroid receptor hypothesis of depression publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(00)00159-7 – volume: 77 start-page: 723 issue: 5 year: 2004 ident: 10.1016/j.pnpbp.2021.110428_bb0280 article-title: Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation publication-title: J. Neurosci. Res. doi: 10.1002/jnr.20200 – year: 2017 ident: 10.1016/j.pnpbp.2021.110428_bb0330 – start-page: 421 year: 2019 ident: 10.1016/j.pnpbp.2021.110428_bb0130 article-title: Neuropeptide transmitters – volume: 24 start-page: 1541 issue: 10 year: 2010 ident: 10.1016/j.pnpbp.2021.110428_bb0185 article-title: Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice publication-title: J. Psychopharmacol. doi: 10.1177/0269881109104851 – volume: 26 start-page: 259 issue: 3 year: 2002 ident: 10.1016/j.pnpbp.2021.110428_bb0100 article-title: The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/S0149-7634(01)00066-5 – volume: 15 start-page: 2893 year: 2019 ident: 10.1016/j.pnpbp.2021.110428_bb0110 article-title: Changes in plasma NPY, IL-1beta and hypocretin in people who died by suicide publication-title: Neuropsychiatr Dis Treat doi: 10.2147/NDT.S219962 – year: 1997 ident: 10.1016/j.pnpbp.2021.110428_bb0040 – volume: 147 start-page: 465 issue: 3 year: 1988 ident: 10.1016/j.pnpbp.2021.110428_bb0050 article-title: Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(88)90182-3 – volume: 1095 start-page: 154 issue: 1 year: 2006 ident: 10.1016/j.pnpbp.2021.110428_bb0075 article-title: CSF serotonin, 5-hydroxyindolacetic acid and neuropeptide Y levels in severe major depressive disorder publication-title: Brain Res. doi: 10.1016/j.brainres.2006.04.026 – volume: 13 issue: 1 year: 2018 ident: 10.1016/j.pnpbp.2021.110428_bb0210 article-title: Enhanced susceptibility to stress and seizures in GAD65 deficient mice publication-title: PLoS One doi: 10.1371/journal.pone.0191794 – start-page: 543 year: 1995 ident: 10.1016/j.pnpbp.2021.110428_bb0305 article-title: Neuropeptide Y and related peptides – volume: 23 start-page: 783 issue: 12 year: 2020 ident: 10.1016/j.pnpbp.2021.110428_bb0125 article-title: A randomized controlled trial of intranasal neuropeptide Y in patients with major depressive disorder publication-title: Int. J. Neuropsychopharmacol. doi: 10.1093/ijnp/pyaa054 – volume: 15 start-page: 1317 issue: 11 year: 2011 ident: 10.1016/j.pnpbp.2021.110428_bb0340 article-title: Central functions of neuropeptide Y in mood and anxiety disorders publication-title: Expert Opin. Ther. Targets doi: 10.1517/14728222.2011.628314 – volume: 216 start-page: 57 issue: 1 year: 1996 ident: 10.1016/j.pnpbp.2021.110428_bb0045 article-title: Plasma neuropeptide Y in patients with major depressive disorder publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(96)13008-1 – volume: 97 start-page: 12852 issue: 23 year: 2000 ident: 10.1016/j.pnpbp.2021.110428_bb0295 article-title: Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.220232997 – volume: 38 start-page: 113 issue: 2 year: 2004 ident: 10.1016/j.pnpbp.2021.110428_bb0065 article-title: Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism publication-title: J. Psychiatr. Res. doi: 10.1016/S0022-3956(03)00101-8 – volume: 65 start-page: 301 issue: 4 year: 2005 ident: 10.1016/j.pnpbp.2021.110428_bb0230 article-title: Neuropeptide Y receptors as therapeutic targets in anxiety and depression publication-title: Drug Dev. Res. doi: 10.1002/ddr.20031 – volume: 38 start-page: 225 issue: 4 year: 2004 ident: 10.1016/j.pnpbp.2021.110428_bb0245 article-title: Interactions between NPY and CRF in the amygdala to regulate emotionality publication-title: Neuropeptides doi: 10.1016/j.npep.2004.05.006 – volume: 414 start-page: 215 issue: 2–3 year: 2001 ident: 10.1016/j.pnpbp.2021.110428_bb0095 article-title: Neuropeptide Y Y(5) receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(01)00768-3 – volume: 6 start-page: 215 issue: 3 year: 1995 ident: 10.1016/j.pnpbp.2021.110428_bb0010 article-title: Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures publication-title: Behav. Pharmacol. doi: 10.1097/00008877-199504000-00001 – volume: 80 start-page: 102001 year: 2020 ident: 10.1016/j.pnpbp.2021.110428_bb0170 article-title: Activation of NPY receptor subtype 1 by [D-his(26)]NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD publication-title: Neuropeptides doi: 10.1016/j.npep.2019.102001 – volume: 64 start-page: 39 year: 2017 ident: 10.1016/j.pnpbp.2021.110428_bb0135 article-title: The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours publication-title: Neuropeptides doi: 10.1016/j.npep.2017.01.004 – volume: 49 start-page: 26 issue: 1 year: 2016 ident: 10.1016/j.pnpbp.2021.110428_bb0180 article-title: The effects of antidepressants on neuropeptide Y in patients with depression and anxiety publication-title: Pharmacopsychiatry doi: 10.1055/s-0035-1565241 – volume: 24 start-page: 1907 issue: 12 year: 2014 ident: 10.1016/j.pnpbp.2021.110428_bb0255 article-title: Low neuropeptide Y in cerebrospinal fluid in bipolar patients is associated with previous and prospective suicide attempts publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2014.10.006 – volume: 197 start-page: 421 issue: 2 year: 2008 ident: 10.1016/j.pnpbp.2021.110428_bb0265 article-title: Neuropeptide Y mediates the initial hypothalamic-pituitary-adrenal response to maternal separation in the neonatal mouse publication-title: J. Endocrinol. doi: 10.1677/JOE-07-0634 – volume: 166 start-page: 1461 issue: 4 year: 2012 ident: 10.1016/j.pnpbp.2021.110428_bb0300 article-title: NPY controls fear conditioning and fear extinction by combined action on Y(1) and Y(2) receptors publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2012.01872.x – volume: 17 start-page: 80 issue: 2 year: 1994 ident: 10.1016/j.pnpbp.2021.110428_bb0060 article-title: Corticotropin-releasing factor and neuropeptide Y: role in emotional integration publication-title: Trends Neurosci. doi: 10.1016/0166-2236(94)90079-5 – volume: 3 start-page: 250 issue: 5 year: 1995 ident: 10.1016/j.pnpbp.2021.110428_bb0120 article-title: Effect of electroconvulsive treatmetn on somatostatin, neuropeptide Y, endothelin, and neurokinin a concentrations in cerebrospinal fluis of depressed patients: a pilot study publication-title: Depression doi: 10.1002/depr.3050030505 – volume: 556 start-page: 520 issue: 7702 year: 2018 ident: 10.1016/j.pnpbp.2021.110428_bb0345 article-title: Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor publication-title: Nature doi: 10.1038/s41586-018-0046-x – volume: 17 start-page: 359 issue: 3 year: 1996 ident: 10.1016/j.pnpbp.2021.110428_bb0165 article-title: Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients publication-title: Peptides doi: 10.1016/0196-9781(96)00013-7 – volume: 18 start-page: 646 issue: 6 year: 2013 ident: 10.1016/j.pnpbp.2021.110428_bb0225 article-title: Neuropeptide Y and posttraumatic stress disorder publication-title: Mol. Psychiatry doi: 10.1038/mp.2012.101 – volume: 2013 start-page: 687575 year: 2013 ident: 10.1016/j.pnpbp.2021.110428_bb0270 article-title: The role of neuropeptides in suicidal behavior: a systematic review publication-title: Biomed. Res. Int. doi: 10.1155/2013/687575 – volume: 158 start-page: 1717 issue: 4 year: 2009 ident: 10.1016/j.pnpbp.2021.110428_bb0290 article-title: Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice publication-title: Neuroscience doi: 10.1016/j.neuroscience.2008.11.048 – volume: 12 start-page: 159 year: 2018 ident: 10.1016/j.pnpbp.2021.110428_bb0140 article-title: Maternal deprivation increases anxiety- and depressive-like Behaviors in an age-dependent fashion and reduces neuropeptide Y expression in the amygdala and hippocampus of male and female young adult rats publication-title: Front. Behav. Neurosci. doi: 10.3389/fnbeh.2018.00159 – volume: 1407 start-page: 27 year: 2011 ident: 10.1016/j.pnpbp.2021.110428_bb0025 article-title: Influence of neuropeptide Y and antidepressants upon cerebral monoamines involved in depression: an in vivo electrochemical study publication-title: Brain Res. doi: 10.1016/j.brainres.2011.05.033 – volume: 59 start-page: 73 issue: 1 year: 1992 ident: 10.1016/j.pnpbp.2021.110428_bb0335 article-title: Reduced neuropeptide Y concentrations in suicide brain publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1992.tb08877.x – volume: 141 start-page: 251 issue: 2 year: 2003 ident: 10.1016/j.pnpbp.2021.110428_bb0215 article-title: Neuropeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety: evidence from Y2 receptor knockout mice publication-title: Behav. Brain Res. doi: 10.1016/S0166-4328(02)00374-1 – volume: 55 start-page: 99 year: 2016 ident: 10.1016/j.pnpbp.2021.110428_bb0220 article-title: Neuropeptide Y: a stressful review publication-title: Neuropeptides doi: 10.1016/j.npep.2015.09.008 – volume: 277 start-page: 264 issue: 1 year: 2000 ident: 10.1016/j.pnpbp.2021.110428_bb0285 article-title: Neuropeptide Y receptor gene y6: multiple deaths or resurrections? publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.2000.3656 – volume: 98 start-page: 524 issue: 4 year: 1989 ident: 10.1016/j.pnpbp.2021.110428_bb0055 article-title: Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models publication-title: Psychopharmacology doi: 10.1007/BF00441953 – volume: 49 start-page: 45 issue: 1 year: 1998 ident: 10.1016/j.pnpbp.2021.110428_bb0320 article-title: Correlations between plasma-neuropeptides and temperament dimensions differ between suicidal patients and healthy controls publication-title: J Affect Disord doi: 10.1016/S0165-0327(97)00197-3 – volume: 1 start-page: 17 issue: 1 year: 2001 ident: 10.1016/j.pnpbp.2021.110428_bb0105 article-title: Reduced neuropeptide Y mRNA levels in the frontal cortex of people with schizophrenia and bipolar disorder publication-title: Brain Res. Gene Expr. Patterns doi: 10.1016/S1567-133X(01)00003-5 – volume: 19 start-page: 359 issue: 2 year: 1998 ident: 10.1016/j.pnpbp.2021.110428_bb0155 article-title: Neuropeptide Y produces anxiety via Y2-type receptors publication-title: Peptides doi: 10.1016/S0196-9781(97)00298-2 – volume: 15 start-page: 1051 issue: 8 year: 2012 ident: 10.1016/j.pnpbp.2021.110428_bb0160 article-title: Quetiapine affects neuropeptide Y and corticotropin-releasing hormone in cerebrospinal fluid from schizophrenia patients: relationship to depression and anxiety symptoms and to treatment response publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S1461145711001556 – volume: 27 start-page: 756 issue: 5 year: 2002 ident: 10.1016/j.pnpbp.2021.110428_bb0080 article-title: Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain. Lithium treatment modifies these changes publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(02)00363-9 – volume: 14 start-page: 479 issue: 6 year: 2004 ident: 10.1016/j.pnpbp.2021.110428_bb0175 article-title: Cerebrospinal neuropeptide Y and substance P in suicide attempters during long-term antidepressant treatment publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2004.01.005 – volume: 38 start-page: 2628 issue: 11 year: 2013 ident: 10.1016/j.pnpbp.2021.110428_bb0195 article-title: Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2013.06.020 – volume: 21 start-page: 3 issue: 1 year: 2018 ident: 10.1016/j.pnpbp.2021.110428_bb0260 article-title: A randomized dose-ranging study of neuropeptide Y in patients with posttraumatic stress disorder publication-title: Int. J. Neuropsychopharmacol. doi: 10.1093/ijnp/pyx109 – volume: 38 start-page: 266 issue: 4 year: 2009 ident: 10.1016/j.pnpbp.2021.110428_bb0145 article-title: Morphological reorganization after repeated corticosterone administration in the hippocampus, nucleus accumbens and amygdala in the rat publication-title: J. Chem. Neuroanat. doi: 10.1016/j.jchemneu.2009.05.009 – volume: 326 start-page: 583 issue: 2 year: 2006 ident: 10.1016/j.pnpbp.2021.110428_bb0250 article-title: Neuropeptides as synaptic transmitters publication-title: Cell Tissue Res. doi: 10.1007/s00441-006-0268-3 – volume: 71 start-page: 419 issue: 3 year: 2002 ident: 10.1016/j.pnpbp.2021.110428_bb0240 article-title: Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(01)00679-7 – volume: 29 start-page: 32 issue: 1 year: 2012 ident: 10.1016/j.pnpbp.2021.110428_bb0115 article-title: Proinflammatory and “resiliency” proteins in the CSF of patients with major depression publication-title: Depress Anxiety doi: 10.1002/da.20876 – volume: 131 start-page: 149 issue: 1–2 year: 2001 ident: 10.1016/j.pnpbp.2021.110428_bb0085 article-title: Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats publication-title: Brain Res. Dev. Brain Res. doi: 10.1016/S0165-3806(01)00264-4 – volume: 4 start-page: 5 year: 2013 ident: 10.1016/j.pnpbp.2021.110428_bb0205 article-title: Neuropeptide Y receptors: how to get subtype selectivity publication-title: Front. Endocrinol. (Lausanne) doi: 10.3389/fendo.2013.00005 – volume: 18 issue: 1 year: 2014 ident: 10.1016/j.pnpbp.2021.110428_bb0275 article-title: Cerebrospinal fluid neuropeptide Y levels in major depression and reported childhood trauma publication-title: Int. J. Neuropsychopharmacol. doi: 10.1093/ijnp/pyu023 – volume: 43 start-page: 1165 issue: 7 year: 2002 ident: 10.1016/j.pnpbp.2021.110428_bb0235 article-title: Neuropeptide Y receptor subtypes in the basolateral nucleus of the amygdala modulate anxiogenic responses in rats publication-title: Neuropharmacology doi: 10.1016/S0028-3908(02)00234-4 – volume: 195 start-page: 547 issue: 4 year: 2008 ident: 10.1016/j.pnpbp.2021.110428_bb0090 article-title: The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice publication-title: Psychopharmacology doi: 10.1007/s00213-007-0945-2 – year: 2019 ident: 10.1016/j.pnpbp.2021.110428_bb0310 article-title: NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway publication-title: Mediat. Inflamm. – volume: 88 start-page: 25 issue: 1 year: 2020 ident: 10.1016/j.pnpbp.2021.110428_bb0315 article-title: Personalized prognostic prediction of treatment outcome for depressed patients in a naturalistic psychiatric hospital setting: a comparison of machine learning approaches publication-title: J. Consult. Clin. Psychol. doi: 10.1037/ccp0000451 – volume: 9 start-page: 205 issue: 3 year: 1999 ident: 10.1016/j.pnpbp.2021.110428_bb0325 article-title: Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt publication-title: Eur Neuropsychopharmacol doi: 10.1016/S0924-977X(98)00026-1 – volume: 1314 start-page: 194 year: 2010 ident: 10.1016/j.pnpbp.2021.110428_bb0150 article-title: A possible role of neuropeptide Y in depression and stress publication-title: Brain Res. doi: 10.1016/j.brainres.2009.09.077 – volume: 25 start-page: 91 issue: 1 year: 2001 ident: 10.1016/j.pnpbp.2021.110428_bb0015 article-title: Neuropeptide Y Y(1) and Y(2) receptor mRNA expression in the prefrontal cortex of psychiatric subjects. Relationship of Y(2) subtype to suicidal behavior publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(00)00231-1 – volume: 156 start-page: 1895 issue: 12 year: 1999 ident: 10.1016/j.pnpbp.2021.110428_bb0190 article-title: Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta1 protein in the prefrontal cortex of teenage suicide subjects publication-title: Am. J. Psychiatry doi: 10.1176/ajp.156.12.1895 – volume: 75 start-page: 101 year: 2019 ident: 10.1016/j.pnpbp.2021.110428_bb0200 article-title: Innate immunity in the postmortem brain of depressed and suicide subjects: role of toll-like receptors publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2018.09.024 – volume: 99 start-page: 57 issue: 1 year: 2021 ident: 10.1016/j.pnpbp.2021.110428_bb0005 article-title: Long term effects of stress on hippocampal function: emphasis on early life stress paradigms and potential involvement of neuropeptide Y publication-title: J. Neurosci. Res. doi: 10.1002/jnr.24614
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Snippet	Neuropeptides are small proteinaceous molecules (3–100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide... Neuropeptides are small proteinaceous molecules (3-100 amino acids) that are secreted by neurons and act on both neuronal and non-neuronal cells. Neuropeptide...
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SubjectTerms	Adult Autopsy Depression Depression - physiopathology Female Hippocampus Humans Male Neuropeptide Y Neuropeptide Y - physiology Prefrontal Cortex Receptors, Neuropeptide Y - physiology RNA, Messenger - metabolism Stress, Psychological - physiopathology Suicide
Title	Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study
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