Malignant transformation of craniopharyngioma

Craniopharyngioma is a well recognised intracranial tumour; malignant transformation has been rarely described. In that case, malignant change occurred following irradiation for local recurrence and information is not provided on the biological behaviour of the tumour or the response to management....

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Bibliographic Details
Published in:Journal of clinical neuroscience Vol. 6; no. 6; pp. 527 - 530
Main Authors: Virik, Kiran, Turner, Jennifer, Garrick, Raymond, Sheehy, John P
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Ltd 01.11.1999
Elsevier
Subjects:
Biological and medical sciences
chemotherapy
craniopharyngioma
malignant transformation
Medical sciences
Neurology
pituitary neoplasm
radiotherapy
Tumors of the nervous system. Phacomatoses
radiotherapy
pituitary neoplasm
malignant transformation
chemotherapy
craniopharyngioma
Endocrinopathy
Case study
Human
Intracranial
Nervous system diseases
Malignant transformation
Tumor
Craniopharyngioma
ISSN:0967-5868, 1532-2653
Online Access:Get full text
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Summary:Craniopharyngioma is a well recognised intracranial tumour; malignant transformation has been rarely described. In that case, malignant change occurred following irradiation for local recurrence and information is not provided on the biological behaviour of the tumour or the response to management. We report a further case of malignant transformation in recurrent craniopharyngioma following radiotherapy. The biological behaviour of malignant change in craniopharyngioma is uncertain so the treatment modalities require consideration of toxicity and other adverse sequelae balanced against anticipated outcome and comorbidities from previous treatments. The pathophysiology and therapeutic strategies are discussed. We review the possible pathogenic link between radiation therapy and malignant transformation.
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ISSN:0967-5868
1532-2653
DOI:10.1016/S0967-5868(99)90019-X