Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma?

Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood a...

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Vydáno v:Frontiers in pediatrics Ročník 7; s. 256
Hlavní autoři: Trivedi, Michelle, Denton, Eve
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 25.06.2019
Témata:
adult
airway
asthma
childhood
pediatric
Pediatrics
asthma
childhood
adult
airway
pediatric
ISSN:2296-2360, 2296-2360
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Abstract Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood and adult asthma have variable presentations, which are described herein. Childhood asthma severity is associated with duration of asthma symptoms, medication use, lung function, low socioeconomic status, racial/ethnic minorities, and a neutrophilic phenotype. Adult asthma severity is associated with increased IgE, elevated FeNO, eosinophilia, obesity, smoking, and low socioeconomic status. Adult onset disease is associated with more respiratory symptoms and asthma medication use despite higher prebronchodilator FEV1/FVC. There is less quiescent disease in adult onset asthma and it appears to be less stable than childhood-onset disease with more relapses and less remissions.
AbstractList Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood and adult asthma have variable presentations, which are described herein. Childhood asthma severity is associated with duration of asthma symptoms, medication use, lung function, low socioeconomic status, racial/ethnic minorities, and a neutrophilic phenotype. Adult asthma severity is associated with increased IgE, elevated FeNO, eosinophilia, obesity, smoking, and low socioeconomic status. Adult onset disease is associated with more respiratory symptoms and asthma medication use despite higher prebronchodilator FEV1/FVC. There is less quiescent disease in adult onset asthma and it appears to be less stable than childhood-onset disease with more relapses and less remissions.Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood and adult asthma have variable presentations, which are described herein. Childhood asthma severity is associated with duration of asthma symptoms, medication use, lung function, low socioeconomic status, racial/ethnic minorities, and a neutrophilic phenotype. Adult asthma severity is associated with increased IgE, elevated FeNO, eosinophilia, obesity, smoking, and low socioeconomic status. Adult onset disease is associated with more respiratory symptoms and asthma medication use despite higher prebronchodilator FEV1/FVC. There is less quiescent disease in adult onset asthma and it appears to be less stable than childhood-onset disease with more relapses and less remissions.
Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood and adult asthma have variable presentations, which are described herein. Childhood asthma severity is associated with duration of asthma symptoms, medication use, lung function, low socioeconomic status, racial/ethnic minorities, and a neutrophilic phenotype. Adult asthma severity is associated with increased IgE, elevated FeNO, eosinophilia, obesity, smoking, and low socioeconomic status. Adult onset disease is associated with more respiratory symptoms and asthma medication use despite higher prebronchodilator FEV1/FVC. There is less quiescent disease in adult onset asthma and it appears to be less stable than childhood-onset disease with more relapses and less remissions.
Author Trivedi, Michelle
Denton, Eve
AuthorAffiliation 1 Division of Pediatric Pulmonology, Department of Pediatrics, University of Massachusetts Medical School , Worcester, MA , United States
3 Department of Respiratory Medicine, Alfred Hospital , Melbourne, VIC , Australia
2 Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School , Worcester, MA , United States
4 Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia
AuthorAffiliation_xml – name: 3 Department of Respiratory Medicine, Alfred Hospital , Melbourne, VIC , Australia
– name: 2 Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School , Worcester, MA , United States
– name: 1 Division of Pediatric Pulmonology, Department of Pediatrics, University of Massachusetts Medical School , Worcester, MA , United States
– name: 4 Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia
Author_xml – sequence: 1
  givenname: Michelle
  surname: Trivedi
  fullname: Trivedi, Michelle
– sequence: 2
  givenname: Eve
  surname: Denton
  fullname: Denton, Eve
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31294006$$D View this record in MEDLINE/PubMed
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Keywords asthma
childhood
adult
airway
pediatric
Language English
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This article was submitted to Pediatric Pulmonology, a section of the journal Frontiers in Pediatrics
Edited by: Steve Turner, University of Aberdeen, United Kingdom
Reviewed by: Basil Elnazir, Tallaght Hospital, Ireland; Aroonwan Preutthipan, Mahidol University, Thailand
OpenAccessLink https://doaj.org/article/a26a75c0f7c440c1a24129811cc37c57
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crossref_primary_10_3389_fped_2019_00256
crossref_citationtrail_10_3389_fped_2019_00256
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PublicationDate 2019-06-25
PublicationDateYYYYMMDD 2019-06-25
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  year: 2019
  text: 2019-06-25
  day: 25
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PublicationTitle Frontiers in pediatrics
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Snippet Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common...
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SubjectTerms adult
airway
asthma
childhood
pediatric
Pediatrics
Title Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma?
URI https://www.ncbi.nlm.nih.gov/pubmed/31294006
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https://pubmed.ncbi.nlm.nih.gov/PMC6603154
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