Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma?

Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood a...

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Vydáno v:Frontiers in pediatrics Ročník 7; s. 256
Hlavní autoři: Trivedi, Michelle, Denton, Eve
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 25.06.2019
Témata:
adult
airway
asthma
childhood
pediatric
Pediatrics
asthma
childhood
adult
airway
pediatric
ISSN:2296-2360, 2296-2360
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Shrnutí:Asthma varies considerably across the life course. Childhood asthma is known for its overall high prevalence with a male predominance prior to puberty, common remission, and rare mortality. Adult asthma is known for its female predominance, uncommon remission, and unusual mortality. Both childhood and adult asthma have variable presentations, which are described herein. Childhood asthma severity is associated with duration of asthma symptoms, medication use, lung function, low socioeconomic status, racial/ethnic minorities, and a neutrophilic phenotype. Adult asthma severity is associated with increased IgE, elevated FeNO, eosinophilia, obesity, smoking, and low socioeconomic status. Adult onset disease is associated with more respiratory symptoms and asthma medication use despite higher prebronchodilator FEV1/FVC. There is less quiescent disease in adult onset asthma and it appears to be less stable than childhood-onset disease with more relapses and less remissions.
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This article was submitted to Pediatric Pulmonology, a section of the journal Frontiers in Pediatrics
Edited by: Steve Turner, University of Aberdeen, United Kingdom
Reviewed by: Basil Elnazir, Tallaght Hospital, Ireland; Aroonwan Preutthipan, Mahidol University, Thailand
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2019.00256