PRMT5 function and targeting in cancer

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as...

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Bibliographic Details
Published in:Cell Stress Vol. 4; no. 8; pp. 199 - 215
Main Authors: Kim, Hyungsoo, Ronai, Ze’ev A.
Format: Journal Article
Language:English
Published: Austria Shared Science Publishers OG 13.07.2020
Subjects:
Histone
mep50
Methylation
Methyltransferase
prmt1
prmt5
Review
Splicing
Transcription
PRMT5
methyltransferase
transcription
PRMT1
methylation
histone
splicing
MEP50
ISSN:2523-0204, 2523-0204
Online Access:Get full text
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Summary:Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling pathways. We discuss PRMT5 effect on histone methylation and methylation of regulatory proteins including those involved in RNA splicing, cell cycle, cell death and metabolic signaling. In all, we highlight the importance of PRMT5 regulation and function in cancer, which provide the foundation for therapeutic modalities targeting PRMT5.
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Please cite this article as: Hyungsoo Kim and Ze'ev A. Ronai (2020). PRMT5 function and targeting in cancer. Cell Stress 4(8): 199-215. doi: 10.15698/cst2020.08.228
Conflict of interest: ZR is a co-founder and serves as scientific advisor to Pangea Therapeutics. HK declares no competing interests.
ISSN:2523-0204
2523-0204
DOI:10.15698/cst2020.08.228