Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes

Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage [TOD] ) and, in turn, elevate risk for cardiovascular disease ( CVD ) events. Methods and Results We related arterial stiffness measures...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Journal of the American Heart Association Ročník 8; číslo 14; s. e012141
Hlavní autori:	Vasan, Ramachandran S., Short, Meghan I., Niiranen, Teemu J., Xanthakis, Vanessa, DeCarli, Charles, Cheng, Susan, Seshadri, Sudha, Mitchell, Gary F.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England John Wiley and Sons Inc 16.07.2019 Wiley
Predmet:	Adult Aged Albuminuria - epidemiology Angina Pectoris - epidemiology Angina, Unstable - epidemiology Arterial Pressure - physiology arterial stiffness cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Carotid-Femoral Pulse Wave Velocity Cohort Studies Echocardiography epidemiology Female Heart Failure - epidemiology Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - epidemiology Incidence Intermittent Claudication - epidemiology Ischemic Attack, Transient - epidemiology Longitudinal Studies Male Manometry Middle Aged Myocardial Infarction - epidemiology Myocardial Infarction - mortality Original Research Prospective Studies pulse wave velocity Stroke - epidemiology target organ damage Vascular Stiffness - physiology arterial stiffness cardiovascular disease epidemiology pulse wave velocity target organ damage
ISSN:	2047-9980, 2047-9980
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage [TOD] ) and, in turn, elevate risk for cardiovascular disease ( CVD ) events. Methods and Results We related arterial stiffness measures (carotid-femoral pulse wave velocity, mean arterial pressure, central pulse pressure) to the prevalence and incidence of TOD (defined as albuminuria and/or echocardiographic left ventricular hypertrophy) in up to 6203 Framingham Study participants (mean age 50±15 years, 54% women). We then related presence of TOD to incident CVD in multivariable Cox regression models without and with adjustment for arterial stiffness measures. Cross-sectionally, greater arterial stiffness was associated with a higher prevalence of TOD (adjusted odds ratios ranging from 1.23 to 1.54 per SD increment in arterial stiffness measure, P<0.01). Prospectively, increased carotid-femoral pulse wave velocity was associated with incident albuminuria (odds ratio per SD 1.28, 95% CI, 1.02-1.61; P<0.05), whereas higher mean arterial pressure and central pulse pressure were associated with incident left ventricular hypertrophy (odds ratio per SD 1.37 and 1.45, respectively; P<0.01). On follow-up, 297 of 5803 participants experienced a first CVD event. Presence of TOD was associated with a 33% greater hazard of incident CVD (95% CI , 0-77%; P<0.05), which was attenuated upon adjustment for baseline arterial stiffness measures by 5-21%. Conclusions Elevated arterial stiffness is associated with presence of TOD and may partially mediate the relations of TOD with incident CVD . Our observations in a large community-based sample suggest that mitigating arterial stiffness may lower the burden of TOD and, in turn, clinical CVD .
AbstractList	Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage [TOD]) and, in turn, elevate risk for cardiovascular disease (CVD) events. Methods and Results We related arterial stiffness measures (carotid‐femoral pulse wave velocity, mean arterial pressure, central pulse pressure) to the prevalence and incidence of TOD (defined as albuminuria and/or echocardiographic left ventricular hypertrophy) in up to 6203 Framingham Study participants (mean age 50±15 years, 54% women). We then related presence of TOD to incident CVD in multivariable Cox regression models without and with adjustment for arterial stiffness measures. Cross‐sectionally, greater arterial stiffness was associated with a higher prevalence of TOD (adjusted odds ratios ranging from 1.23 to 1.54 per SD increment in arterial stiffness measure, P<0.01). Prospectively, increased carotid‐femoral pulse wave velocity was associated with incident albuminuria (odds ratio per SD 1.28, 95% CI, 1.02–1.61; P<0.05), whereas higher mean arterial pressure and central pulse pressure were associated with incident left ventricular hypertrophy (odds ratio per SD 1.37 and 1.45, respectively; P<0.01). On follow‐up, 297 of 5803 participants experienced a first CVD event. Presence of TOD was associated with a 33% greater hazard of incident CVD (95% CI, 0–77%; P<0.05), which was attenuated upon adjustment for baseline arterial stiffness measures by 5–21%. Conclusions Elevated arterial stiffness is associated with presence of TOD and may partially mediate the relations of TOD with incident CVD. Our observations in a large community‐based sample suggest that mitigating arterial stiffness may lower the burden of TOD and, in turn, clinical CVD. Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage [TOD] ) and, in turn, elevate risk for cardiovascular disease ( CVD ) events. Methods and Results We related arterial stiffness measures (carotid-femoral pulse wave velocity, mean arterial pressure, central pulse pressure) to the prevalence and incidence of TOD (defined as albuminuria and/or echocardiographic left ventricular hypertrophy) in up to 6203 Framingham Study participants (mean age 50±15 years, 54% women). We then related presence of TOD to incident CVD in multivariable Cox regression models without and with adjustment for arterial stiffness measures. Cross-sectionally, greater arterial stiffness was associated with a higher prevalence of TOD (adjusted odds ratios ranging from 1.23 to 1.54 per SD increment in arterial stiffness measure, P<0.01). Prospectively, increased carotid-femoral pulse wave velocity was associated with incident albuminuria (odds ratio per SD 1.28, 95% CI, 1.02-1.61; P<0.05), whereas higher mean arterial pressure and central pulse pressure were associated with incident left ventricular hypertrophy (odds ratio per SD 1.37 and 1.45, respectively; P<0.01). On follow-up, 297 of 5803 participants experienced a first CVD event. Presence of TOD was associated with a 33% greater hazard of incident CVD (95% CI , 0-77%; P<0.05), which was attenuated upon adjustment for baseline arterial stiffness measures by 5-21%. Conclusions Elevated arterial stiffness is associated with presence of TOD and may partially mediate the relations of TOD with incident CVD . Our observations in a large community-based sample suggest that mitigating arterial stiffness may lower the burden of TOD and, in turn, clinical CVD .Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage [TOD] ) and, in turn, elevate risk for cardiovascular disease ( CVD ) events. Methods and Results We related arterial stiffness measures (carotid-femoral pulse wave velocity, mean arterial pressure, central pulse pressure) to the prevalence and incidence of TOD (defined as albuminuria and/or echocardiographic left ventricular hypertrophy) in up to 6203 Framingham Study participants (mean age 50±15 years, 54% women). We then related presence of TOD to incident CVD in multivariable Cox regression models without and with adjustment for arterial stiffness measures. Cross-sectionally, greater arterial stiffness was associated with a higher prevalence of TOD (adjusted odds ratios ranging from 1.23 to 1.54 per SD increment in arterial stiffness measure, P<0.01). Prospectively, increased carotid-femoral pulse wave velocity was associated with incident albuminuria (odds ratio per SD 1.28, 95% CI, 1.02-1.61; P<0.05), whereas higher mean arterial pressure and central pulse pressure were associated with incident left ventricular hypertrophy (odds ratio per SD 1.37 and 1.45, respectively; P<0.01). On follow-up, 297 of 5803 participants experienced a first CVD event. Presence of TOD was associated with a 33% greater hazard of incident CVD (95% CI , 0-77%; P<0.05), which was attenuated upon adjustment for baseline arterial stiffness measures by 5-21%. Conclusions Elevated arterial stiffness is associated with presence of TOD and may partially mediate the relations of TOD with incident CVD . Our observations in a large community-based sample suggest that mitigating arterial stiffness may lower the burden of TOD and, in turn, clinical CVD .
Author	Vasan, Ramachandran S. Short, Meghan I. Xanthakis, Vanessa DeCarli, Charles Cheng, Susan Mitchell, Gary F. Niiranen, Teemu J. Seshadri, Sudha
AuthorAffiliation	3 Section of Cardiology Department of Medicine Boston University School of Medicine Boston MA 4 Department of Epidemiology Boston University School of Public Health Boston MA 2 Section of Preventive Medicine Department of Medicine Boston University School of Medicine Boston MA 10 Biggs Institute for Alzheimer's Disease University of Texas Health Sciences Center at San Antonio TX 11 Cardiovascular Engineering, Inc. Norwood MA 9 Smidt Heart Institute Cedars‐Sinai Medical Center Los Angeles CA 7 Department of Public Health Solutions National Institute for Health and Welfare Turku Finland 8 University of California Davis CA 5 Department of Biostatistics Boston University School of Public Health Boston MA 6 Department of Medicine Turku University Hospital and University of Turku Finland 1 National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA
AuthorAffiliation_xml	– name: 6 Department of Medicine Turku University Hospital and University of Turku Finland – name: 2 Section of Preventive Medicine Department of Medicine Boston University School of Medicine Boston MA – name: 3 Section of Cardiology Department of Medicine Boston University School of Medicine Boston MA – name: 11 Cardiovascular Engineering, Inc. Norwood MA – name: 1 National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA – name: 4 Department of Epidemiology Boston University School of Public Health Boston MA – name: 8 University of California Davis CA – name: 9 Smidt Heart Institute Cedars‐Sinai Medical Center Los Angeles CA – name: 7 Department of Public Health Solutions National Institute for Health and Welfare Turku Finland – name: 5 Department of Biostatistics Boston University School of Public Health Boston MA – name: 10 Biggs Institute for Alzheimer's Disease University of Texas Health Sciences Center at San Antonio TX
Author_xml	– sequence: 1 givenname: Ramachandran S. surname: Vasan fullname: Vasan, Ramachandran S. organization: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA, Section of Preventive Medicine Department of Medicine Boston University School of Medicine Boston MA, Section of Cardiology Department of Medicine Boston University School of Medicine Boston MA, Department of Epidemiology Boston University School of Public Health Boston MA – sequence: 2 givenname: Meghan I. surname: Short fullname: Short, Meghan I. organization: Department of Biostatistics Boston University School of Public Health Boston MA – sequence: 3 givenname: Teemu J. surname: Niiranen fullname: Niiranen, Teemu J. organization: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA, Department of Medicine Turku University Hospital and University of Turku Finland, Department of Public Health Solutions National Institute for Health and Welfare Turku Finland – sequence: 4 givenname: Vanessa surname: Xanthakis fullname: Xanthakis, Vanessa organization: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA, Section of Preventive Medicine Department of Medicine Boston University School of Medicine Boston MA, Department of Biostatistics Boston University School of Public Health Boston MA – sequence: 5 givenname: Charles surname: DeCarli fullname: DeCarli, Charles organization: University of California Davis CA – sequence: 6 givenname: Susan surname: Cheng fullname: Cheng, Susan organization: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA, Smidt Heart Institute Cedars‐Sinai Medical Center Los Angeles CA – sequence: 7 givenname: Sudha surname: Seshadri fullname: Seshadri, Sudha organization: National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA, Biggs Institute for Alzheimer's Disease University of Texas Health Sciences Center at San Antonio TX – sequence: 8 givenname: Gary F. surname: Mitchell fullname: Mitchell, Gary F. organization: Cardiovascular Engineering, Inc. Norwood MA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31303106$$D View this record in MEDLINE/PubMed
BookMark	eNp1UstuFDEQtFAQeZAzNzRHDtnEb48vSMsmkEWR9kA4Wx5Pz-Bo1g62J4i_x8mGKEHCF5faVdVtdR2ivRADIPSO4FNCJDn7urxcVqRPMaGEk1fogGKuFlq3eO8Z3kfHOd_geiRVTOg3aJ8RhhnB8gC5dSiQEky2-Bhy8wnKL4DQLFMtezs134ofhgA5nzTXNo1Qmk0abWjO7daOcNLY0Dcrm3of72x282RTc-4z2AzNZi4ubiG_Ra8HO2U4fryP0PfPF9ery8XV5st6tbxaOC50WTgsgXQKJB9whweGB9d3mglJtOqB9kRoIluntFYgqHQgBuDYqarhylHMjtB659tHe2Nuk9_a9NtE681DIabR2FS8m8B0PWFDKyTmLeVKsLbtaM8VVtZJhfuhen3ced3O3RZ6B6EkO70wffkS_A8zxjsjpaSEsmrw4dEgxZ8z5GK2PjuYJhsgztlQKtr6I4F5pb5_3uupyd8tVcLZjuBSzDnB8EQh2NxHwdxHoSJtdlGoCvGPwvnysOI6rJ_-q_sDxbu20A
CitedBy_id	crossref_primary_10_1016_j_ejrad_2020_109305 crossref_primary_10_1038_s41371_022_00697_7 crossref_primary_10_1038_s41440_024_01922_1 crossref_primary_10_1161_HYPERTENSIONAHA_121_17579 crossref_primary_10_1161_HYPERTENSIONAHA_121_18502 crossref_primary_10_1161_STROKEAHA_124_045903 crossref_primary_10_1016_j_rce_2020_01_006 crossref_primary_10_1016_j_mbm_2025_100144 crossref_primary_10_1016_j_jstrokecerebrovasdis_2020_105153 crossref_primary_10_1161_CIRCRESAHA_121_318082 crossref_primary_10_1016_j_artere_2021_09_002 crossref_primary_10_1161_HYPERTENSIONAHA_122_20434 crossref_primary_10_1080_14789450_2024_2436401 crossref_primary_10_2991_artres_k_191202_001 crossref_primary_10_1161_HYPERTENSIONAHA_120_16915 crossref_primary_10_1161_STROKEAHA_122_038809 crossref_primary_10_1038_s41371_025_01062_0 crossref_primary_10_1097_HJH_0000000000003053 crossref_primary_10_1186_s43044_020_0040_0 crossref_primary_10_1038_s41440_025_02219_7 crossref_primary_10_1109_TMI_2022_3141613 crossref_primary_10_1111_jch_70038 crossref_primary_10_1111_1744_9987_13754 crossref_primary_10_1161_ATVBAHA_120_313128 crossref_primary_10_29328_journal_jccm_1001131 crossref_primary_10_3390_biomedicines11041065 crossref_primary_10_1016_j_pcad_2020_12_010 crossref_primary_10_1161_HYPERTENSIONAHA_121_17702 crossref_primary_10_1056_NEJMc1911059 crossref_primary_10_1186_s40885_024_00288_3 crossref_primary_10_1080_14756366_2024_2403736 crossref_primary_10_1161_HYPERTENSIONAHA_121_18075 crossref_primary_10_7759_cureus_26908 crossref_primary_10_3390_nu12072160 crossref_primary_10_1038_s41440_023_01390_z crossref_primary_10_1016_j_metabol_2021_154766 crossref_primary_10_1161_JAHA_121_024769 crossref_primary_10_1016_j_atherosclerosis_2023_117247 crossref_primary_10_1038_s41598_021_88855_8 crossref_primary_10_1186_s12989_024_00603_8 crossref_primary_10_1097_JOM_0000000000003119 crossref_primary_10_2459_JCM_0000000000001287 crossref_primary_10_1007_s13167_022_00298_x crossref_primary_10_1186_s12944_019_1152_y crossref_primary_10_3389_fcvm_2023_1090458 crossref_primary_10_1161_HYPERTENSIONAHA_120_14515 crossref_primary_10_3390_jcm11092512 crossref_primary_10_3390_jcdd10020044 crossref_primary_10_1007_s40292_021_00503_4 crossref_primary_10_3389_fcvm_2022_1013876 crossref_primary_10_2337_dc22_1703 crossref_primary_10_3389_fcvm_2022_938567 crossref_primary_10_1038_s41371_023_00874_2 crossref_primary_10_1016_j_jjcc_2022_03_013 crossref_primary_10_1161_HYPERTENSIONAHA_121_18776 crossref_primary_10_1111_ctr_70173 crossref_primary_10_1136_bmjopen_2023_073649 crossref_primary_10_3389_fcvm_2022_839875 crossref_primary_10_1007_s40620_021_01159_y crossref_primary_10_3389_fcvm_2025_1549878 crossref_primary_10_1097_JOM_0000000000003185 crossref_primary_10_1161_HYPERTENSIONAHA_120_14787 crossref_primary_10_3390_nu11112674 crossref_primary_10_1111_ene_16139 crossref_primary_10_1161_JAHA_120_017165
Cites_doi	10.1161/HYPERTENSIONAHA.111.177469 10.1212/WNL.0000000000002368 10.1001/2012.jama.10503 10.2174/1874609811205020157 10.1097/HJH.0000000000000686 10.1161/STROKEAHA.116.012949 10.1177/1753944709338942 10.1161/CIRCULATIONAHA.105.555235 10.1152/japplphysiol.90549.2008 10.2105/AJPH.41.3.279 10.1681/ASN.2009010074 10.1093/aje/kwm021 10.1159/000324215 10.1016/j.jacc.2015.08.888 10.1038/jhh.2013.103 10.5114/aoms.2017.69240 10.1161/CIRCULATIONAHA.109.914507 10.1161/CIRCULATIONAHA.110.989145 10.1016/j.neurobiolaging.2013.08.026 10.1053/j.ajkd.2011.08.015 10.1681/ASN.V1341034 10.1093/oxfordjournals.aje.a112813 10.1161/STROKEAHA.112.656744 10.1161/HYPERTENSIONAHA.116.08749 10.1016/j.jacc.2012.07.054 10.1001/jama.292.19.2343 10.1161/01.HYP.0000128420.01881.aa 10.2147/CIA.S133691 10.1161/JAHA.115.002189 10.1093/eurheartj/ehy339 10.1016/j.neurobiolaging.2004.05.004 10.1161/CIRCULATIONAHA.109.886655 10.2337/diacare.10.4.414 10.1161/JAHA.115.002693 10.1001/jama.292.19.2350 10.1093/brain/awr253 10.2337/dc11-2245 10.1161/01.HYP.0000154082.72286.2a 10.1161/JAHA.116.004168 10.1016/j.echo.2014.10.003 10.1161/CIRCRESAHA.118.312563 10.1161/HYPERTENSIONAHA.109.136655 10.1161/HYPERTENSIONAHA.111.00430 10.1053/j.ajkd.2018.04.018
ContentType	Journal Article
Copyright	2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
Copyright_xml	– notice: 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA
DOI	10.1161/JAHA.119.012141
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
DocumentTitleAlternate	Vasan et al
EISSN	2047-9980
ExternalDocumentID	oai_doaj_org_article_bd13f8560482475388b2d4707ac670df PMC6662123 31303106 10_1161_JAHA_119_012141
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NHLBI NIH HHS grantid: R01 HL077447 – fundername: NINDS NIH HHS grantid: UH3 NS100605 – fundername: NHLBI NIH HHS grantid: R01 HL107385 – fundername: NINDS NIH HHS grantid: R01 NS017950 – fundername: NHLBI NIH HHS grantid: R01 HL131532 – fundername: NHLBI NIH HHS grantid: R01 HL070100 – fundername: NHLBI NIH HHS grantid: R01 HL134168 – fundername: NHLBI NIH HHS grantid: R01 HL126136 – fundername: NHLBI NIH HHS grantid: R01 HL080124 – fundername: NIA NIH HHS grantid: RF1 AG059421 – fundername: Evans Medical Foundation – fundername: National Heart, Lung, and Blood Institute's FHS (National Institutes of Health [NIH] grantid: N01‐HC‐25195; HHSN268201500001I; 75N92019D00031; HL080124; HL071039; HL077447; HL107385; 1R01HL126136; 5R01HL107385; 1R01HL60040; 1RO1HL70100; R01HL131532; R01HL134168 – fundername: Department of Medicine, Boston University School of Medicine
GroupedDBID	0R~ 1OC 53G 5VS 8-1 AAMMB AAYXX AAZKR ACGFO ACXQS ADBBV ADKYN ADZMN AEFGJ AEGXH AENEX AGXDD AIAGR AIDQK AIDYY ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU BAWUL BCNDV CITATION DIK EBS EMOBN GODZA GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 RAH RNS RPM WIN 24P ACCMX CGR CUY CVF ECM EIF NPM 7X8 5PM
ID	FETCH-LOGICAL-c459t-c06e1b7e64f0b0f30fcdb9356197de2d159168c7997e526ce5fe40c71b747c203
IEDL.DBID	DOA
ISICitedReferencesCount	96
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000484581100016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2047-9980
IngestDate	Mon Nov 10 04:25:56 EST 2025 Tue Nov 04 01:59:33 EST 2025 Sun Nov 09 14:30:45 EST 2025 Mon Jul 21 05:55:11 EDT 2025 Sat Nov 29 06:05:47 EST 2025 Tue Nov 18 21:42:02 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	14
Keywords	arterial stiffness cardiovascular disease epidemiology pulse wave velocity target organ damage
Language	English
License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c459t-c06e1b7e64f0b0f30fcdb9356197de2d159168c7997e526ce5fe40c71b747c203
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://doaj.org/article/bd13f8560482475388b2d4707ac670df
PMID	31303106
PQID	2258159504
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_bd13f8560482475388b2d4707ac670df pubmedcentral_primary_oai_pubmedcentral_nih_gov_6662123 proquest_miscellaneous_2258159504 pubmed_primary_31303106 crossref_primary_10_1161_JAHA_119_012141 crossref_citationtrail_10_1161_JAHA_119_012141
PublicationCentury	2000
PublicationDate	2019-07-16
PublicationDateYYYYMMDD	2019-07-16
PublicationDate_xml	– month: 07 year: 2019 text: 2019-07-16 day: 16
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England – name: Hoboken
PublicationTitle	Journal of the American Heart Association
PublicationTitleAlternate	J Am Heart Assoc
PublicationYear	2019
Publisher	John Wiley and Sons Inc Wiley
Publisher_xml	– name: John Wiley and Sons Inc – name: Wiley
References	e_1_3_1_21_2 e_1_3_1_43_2 e_1_3_1_22_2 e_1_3_1_44_2 e_1_3_1_23_2 e_1_3_1_45_2 e_1_3_1_46_2 e_1_3_1_8_2 e_1_3_1_7_2 e_1_3_1_40_2 e_1_3_1_41_2 e_1_3_1_9_2 e_1_3_1_20_2 e_1_3_1_42_2 e_1_3_1_4_2 e_1_3_1_29_2 e_1_3_1_3_2 e_1_3_1_6_2 e_1_3_1_5_2 e_1_3_1_25_2 e_1_3_1_48_2 e_1_3_1_26_2 e_1_3_1_47_2 e_1_3_1_2_2 e_1_3_1_27_2 e_1_3_1_28_2 e_1_3_1_49_2 Quan SF (e_1_3_1_24_2) 1997; 20 e_1_3_1_32_2 e_1_3_1_33_2 e_1_3_1_34_2 Kannel WB (e_1_3_1_36_2) 1987 e_1_3_1_35_2 e_1_3_1_13_2 e_1_3_1_12_2 e_1_3_1_11_2 e_1_3_1_30_2 e_1_3_1_10_2 e_1_3_1_31_2 e_1_3_1_17_2 e_1_3_1_16_2 e_1_3_1_15_2 e_1_3_1_14_2 e_1_3_1_37_2 e_1_3_1_19_2 e_1_3_1_38_2 e_1_3_1_18_2 e_1_3_1_39_2
References_xml	– ident: e_1_3_1_11_2 doi: 10.1161/HYPERTENSIONAHA.111.177469 – volume-title: Section 34: some risk factors related to the annual incidence of cardiovascular disease and death in pooled repeated biennial measurements. Framingham Heart Study, 30 Year Follow‐Up year: 1987 ident: e_1_3_1_36_2 – ident: e_1_3_1_16_2 doi: 10.1212/WNL.0000000000002368 – ident: e_1_3_1_29_2 doi: 10.1001/2012.jama.10503 – ident: e_1_3_1_12_2 doi: 10.2174/1874609811205020157 – ident: e_1_3_1_19_2 doi: 10.1097/HJH.0000000000000686 – ident: e_1_3_1_13_2 doi: 10.1161/STROKEAHA.116.012949 – ident: e_1_3_1_10_2 doi: 10.1177/1753944709338942 – ident: e_1_3_1_43_2 doi: 10.1161/CIRCULATIONAHA.105.555235 – ident: e_1_3_1_7_2 doi: 10.1152/japplphysiol.90549.2008 – ident: e_1_3_1_21_2 doi: 10.2105/AJPH.41.3.279 – ident: e_1_3_1_15_2 doi: 10.1681/ASN.2009010074 – ident: e_1_3_1_23_2 doi: 10.1093/aje/kwm021 – ident: e_1_3_1_45_2 doi: 10.1159/000324215 – ident: e_1_3_1_40_2 doi: 10.1016/j.jacc.2015.08.888 – ident: e_1_3_1_41_2 doi: 10.1038/jhh.2013.103 – ident: e_1_3_1_44_2 doi: 10.5114/aoms.2017.69240 – ident: e_1_3_1_27_2 doi: 10.1161/CIRCULATIONAHA.109.914507 – ident: e_1_3_1_35_2 doi: 10.1161/CIRCULATIONAHA.110.989145 – ident: e_1_3_1_9_2 doi: 10.1016/j.neurobiolaging.2013.08.026 – ident: e_1_3_1_17_2 doi: 10.1053/j.ajkd.2011.08.015 – ident: e_1_3_1_26_2 – ident: e_1_3_1_32_2 doi: 10.1681/ASN.V1341034 – ident: e_1_3_1_25_2 – ident: e_1_3_1_22_2 doi: 10.1093/oxfordjournals.aje.a112813 – ident: e_1_3_1_33_2 doi: 10.1161/STROKEAHA.112.656744 – ident: e_1_3_1_38_2 doi: 10.1161/HYPERTENSIONAHA.116.08749 – ident: e_1_3_1_42_2 doi: 10.1016/j.jacc.2012.07.054 – ident: e_1_3_1_4_2 doi: 10.1001/jama.292.19.2343 – ident: e_1_3_1_28_2 doi: 10.1161/01.HYP.0000128420.01881.aa – ident: e_1_3_1_47_2 doi: 10.2147/CIA.S133691 – ident: e_1_3_1_39_2 doi: 10.1161/JAHA.115.002189 – ident: e_1_3_1_2_2 doi: 10.1093/eurheartj/ehy339 – ident: e_1_3_1_34_2 doi: 10.1016/j.neurobiolaging.2004.05.004 – ident: e_1_3_1_37_2 doi: 10.1161/CIRCULATIONAHA.109.886655 – ident: e_1_3_1_31_2 doi: 10.2337/diacare.10.4.414 – ident: e_1_3_1_14_2 doi: 10.1161/JAHA.115.002693 – ident: e_1_3_1_3_2 doi: 10.1001/jama.292.19.2350 – ident: e_1_3_1_8_2 doi: 10.1093/brain/awr253 – ident: e_1_3_1_18_2 doi: 10.2337/dc11-2245 – ident: e_1_3_1_6_2 doi: 10.1161/01.HYP.0000154082.72286.2a – ident: e_1_3_1_46_2 doi: 10.1161/JAHA.116.004168 – volume: 20 start-page: 1077 year: 1997 ident: e_1_3_1_24_2 article-title: The Sleep Heart Health Study: design, rationale, and methods publication-title: Sleep – ident: e_1_3_1_30_2 doi: 10.1016/j.echo.2014.10.003 – ident: e_1_3_1_49_2 doi: 10.1161/CIRCRESAHA.118.312563 – ident: e_1_3_1_5_2 doi: 10.1161/HYPERTENSIONAHA.109.136655 – ident: e_1_3_1_20_2 doi: 10.1161/HYPERTENSIONAHA.111.00430 – ident: e_1_3_1_48_2 doi: 10.1053/j.ajkd.2018.04.018
SSID	ssj0000627359
Score	2.5062973
Snippet	Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e012141
SubjectTerms	Adult Aged Albuminuria - epidemiology Angina Pectoris - epidemiology Angina, Unstable - epidemiology Arterial Pressure - physiology arterial stiffness cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Carotid-Femoral Pulse Wave Velocity Cohort Studies Echocardiography epidemiology Female Heart Failure - epidemiology Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - epidemiology Incidence Intermittent Claudication - epidemiology Ischemic Attack, Transient - epidemiology Longitudinal Studies Male Manometry Middle Aged Myocardial Infarction - epidemiology Myocardial Infarction - mortality Original Research Prospective Studies pulse wave velocity Stroke - epidemiology target organ damage Vascular Stiffness - physiology
Title	Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes
URI	https://www.ncbi.nlm.nih.gov/pubmed/31303106 https://www.proquest.com/docview/2258159504 https://pubmed.ncbi.nlm.nih.gov/PMC6662123 https://doaj.org/article/bd13f8560482475388b2d4707ac670df
Volume	8
WOSCitedRecordID	wos000484581100016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2047-9980 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000627359 issn: 2047-9980 databaseCode: DOA dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2047-9980 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000627359 issn: 2047-9980 databaseCode: M~E dateStart: 20120101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 2047-9980 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000627359 issn: 2047-9980 databaseCode: WIN dateStart: 20120101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BhRCXquWZ0lZG4sChae3Eie3j9qUK0YJEkfYWxS91JUjRbpYjv52xnV1tEIgLl8hKbMUaj2e-scefAd5qhMno6WReatfm3FOZay1M7r3BWKyybKDM_yBubuR0qj5tXPUVcsISPXAS3Im2rPQS_TKXBUdsLaUuLBdUtKYW1PpgfRH1bARTyQajW67UwOWDqObk_eRqgiV1HEjMOBu5ocjW_yeI-Xum5IbrudyB7QEzkknq6y48cN1TeHw97Io_AxOX9eartDZymnKvQoOoX-RzP_M-2LQjchszv0k8gknO229oTo5I21lyNkpMJedp44Z8XPaok27xHL5cXtyeXeXD5Qm54ZXqc0Nrx7RwNcpfU19Sb6xWJcIlJawrLMIYVksjlBKuKmrjKu84NQLbcGEKWr6Are6-c6-AlF4I0TLmBLM8UP5x7aSWha21K3ECZ3C8kmVjBmbxcMHF1yZGGDVrgvCxpJok_AzerRt8T6Qaf696GgZnXS2wYccXqCPNoCPNv3QkgzeroW1w9oQtkbZz98tFg9ZMoiQqyjN4mYZ6_asyuHeMmDMQIyUY9WX8pZvdRYZujAkDJNj7H51_DU8QpIWTZjmr92Grny_dATwyP_rZYn4ID8VUHkblx-f1z4tfwvAHUg
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interrelations+Between+Arterial+Stiffness%2C+Target+Organ+Damage%2C+and+Cardiovascular+Disease+Outcomes&rft.jtitle=Journal+of+the+American+Heart+Association&rft.au=Vasan%2C+Ramachandran+S&rft.au=Short%2C+Meghan+I&rft.au=Niiranen%2C+Teemu+J&rft.au=Xanthakis%2C+Vanessa&rft.date=2019-07-16&rft.eissn=2047-9980&rft.volume=8&rft.issue=14&rft.spage=e012141&rft_id=info:doi/10.1161%2FJAHA.119.012141&rft_id=info%3Apmid%2F31303106&rft.externalDocID=31303106
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2047-9980&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2047-9980&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2047-9980&client=summon