Mouse fMRI under ketamine and xylazine anesthesia: Robust contralateral somatosensory cortex activation in response to forepaw stimulation

Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in f...

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Vydáno v:NeuroImage (Orlando, Fla.) Ročník 177; s. 30 - 44
Hlavní autoři: Shim, Hyun-Ji, Jung, Won Beom, Schlegel, Felix, Lee, Joonsung, Kim, Sangwoo, Lee, Jungryun, Kim, Seong-Gi
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 15.08.2018
Elsevier Limited
Témata:
Anesthesia
Anesthetics
Anesthetics - administration & dosage
Animal models
Animals
Biophysics
BOLD
Cerebral blood flow
Cerebrovascular Circulation - physiology
Cortex (cingulate)
Cortex (somatosensory)
Electric Stimulation
Electrical stimulation
Forelimb - physiology
Functional magnetic resonance imaging
Functional Neuroimaging - methods
Isoflurane
Ketamine
Ketamine - administration & dosage
Laboratory animals
Magnetic Resonance Imaging - methods
Male
Mice
Mice, Inbred C57BL
Models, Animal
Neuroimaging
Optical Imaging
Optical intrinsic signal
Physiology
Resting state fMRI
Rodents
Somatosensory Cortex - diagnostic imaging
Somatosensory Cortex - physiology
Studies
Thalamus
Xylazine
Xylazine - administration & dosage
Jerusalem Israel
United States > US
Israel
Resting state fMRI
Electrical stimulation
BOLD
Anesthetics
Optical intrinsic signal
Isoflurane
ISSN:1053-8119, 1095-9572, 1095-9572
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Abstract Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9.4 T, and 4 Hz stimulation with 0.5 ms and 0.5 mA pulses induced the highest hemodynamic response. For 20-s 4-Hz unilateral forepaw stimulation, localized BOLD activity was consistently found in the contralateral primary forelimb somatosensory cortex (S1FL), while no significant change was observed in the ipsilateral S1FL. The mean magnitude was 1.44 ± 0.20% SEM (n = 9) in the contralateral S1FL and 0.69 ± 0.10% in the contralateral thalamus. The variability of evoked fMRI responses across sessions was investigated by comparing with resting state fMRI (rsfMRI) functional connectivity (FC). Evoked responses in S1FL were correlated positively with rsfMRI FC between bilateral S1FL (r = 0.63 to 0.69) and negatively with FC between S1FL and the anterior cingulate cortex (r = −0.50 to −0.57), suggesting that rsfMRI FC is a good index of the evoked fMRI response and anesthetized animal condition. Finally, three weekly fMRI scans were performed in 5 mice, and localized activity was reproducibly observed in S1FL, with a success rate of 70–95%. In summary, our developed fMRI protocol can be used for mapping functions of mouse models. •Bilateral BOLD response induced by forepaw stimulation is observed under isoflurane.•Ketamine and xylazine anesthesia is used for mouse fMRI.•Forepaw stimulation of 4 Hz evokes the highest hemodynamic response.•BOLD activation is reproducibly localized at the contralateral somatosensory cortex.•Resting-state functional connectivity predicts evoked fMRI responses.
AbstractList Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9.4 T, and 4 Hz stimulation with 0.5 ms and 0.5 mA pulses induced the highest hemodynamic response. For 20-s 4-Hz unilateral forepaw stimulation, localized BOLD activity was consistently found in the contralateral primary forelimb somatosensory cortex (S1FL), while no significant change was observed in the ipsilateral S1FL. The mean magnitude was 1.44 ± 0.20% SEM (n = 9) in the contralateral S1FL and 0.69 ± 0.10% in the contralateral thalamus. The variability of evoked fMRI responses across sessions was investigated by comparing with resting state fMRI (rsfMRI) functional connectivity (FC). Evoked responses in S1FL were correlated positively with rsfMRI FC between bilateral S1FL (r = 0.63 to 0.69) and negatively with FC between S1FL and the anterior cingulate cortex (r = −0.50 to −0.57), suggesting that rsfMRI FC is a good index of the evoked fMRI response and anesthetized animal condition. Finally, three weekly fMRI scans were performed in 5 mice, and localized activity was reproducibly observed in S1FL, with a success rate of 70–95%. In summary, our developed fMRI protocol can be used for mapping functions of mouse models. •Bilateral BOLD response induced by forepaw stimulation is observed under isoflurane.•Ketamine and xylazine anesthesia is used for mouse fMRI.•Forepaw stimulation of 4 Hz evokes the highest hemodynamic response.•BOLD activation is reproducibly localized at the contralateral somatosensory cortex.•Resting-state functional connectivity predicts evoked fMRI responses.
Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9.4 T, and 4 Hz stimulation with 0.5 ms and 0.5 mA pulses induced the highest hemodynamic response. For 20-s 4-Hz unilateral forepaw stimulation, localized BOLD activity was consistently found in the contralateral primary forelimb somatosensory cortex (S1FL), while no significant change was observed in the ipsilateral S1FL. The mean magnitude was 1.44 ± 0.20% SEM (n = 9) in the contralateral S1FL and 0.69 ± 0.10% in the contralateral thalamus. The variability of evoked fMRI responses across sessions was investigated by comparing with resting state fMRI (rsfMRI) functional connectivity (FC). Evoked responses in S1FL were correlated positively with rsfMRI FC between bilateral S1FL (r = 0.63 to 0.69) and negatively with FC between S1FL and the anterior cingulate cortex (r = -0.50 to -0.57), suggesting that rsfMRI FC is a good index of the evoked fMRI response and anesthetized animal condition. Finally, three weekly fMRI scans were performed in 5 mice, and localized activity was reproducibly observed in S1FL, with a success rate of 70-95%. In summary, our developed fMRI protocol can be used for mapping functions of mouse models.
Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9.4 T, and 4 Hz stimulation with 0.5 ms and 0.5 mA pulses induced the highest hemodynamic response. For 20-s 4-Hz unilateral forepaw stimulation, localized BOLD activity was consistently found in the contralateral primary forelimb somatosensory cortex (S1FL), while no significant change was observed in the ipsilateral S1FL. The mean magnitude was 1.44 ± 0.20% SEM (n = 9) in the contralateral S1FL and 0.69 ± 0.10% in the contralateral thalamus. The variability of evoked fMRI responses across sessions was investigated by comparing with resting state fMRI (rsfMRI) functional connectivity (FC). Evoked responses in S1FL were correlated positively with rsfMRI FC between bilateral S1FL (r = 0.63 to 0.69) and negatively with FC between S1FL and the anterior cingulate cortex (r = −0.50 to −0.57), suggesting that rsfMRI FC is a good index of the evoked fMRI response and anesthetized animal condition. Finally, three weekly fMRI scans were performed in 5 mice, and localized activity was reproducibly observed in S1FL, with a success rate of 70–95%. In summary, our developed fMRI protocol can be used for mapping functions of mouse models.
Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9.4 T, and 4 Hz stimulation with 0.5 ms and 0.5 mA pulses induced the highest hemodynamic response. For 20-s 4-Hz unilateral forepaw stimulation, localized BOLD activity was consistently found in the contralateral primary forelimb somatosensory cortex (S1FL), while no significant change was observed in the ipsilateral S1FL. The mean magnitude was 1.44 ± 0.20% SEM (n = 9) in the contralateral S1FL and 0.69 ± 0.10% in the contralateral thalamus. The variability of evoked fMRI responses across sessions was investigated by comparing with resting state fMRI (rsfMRI) functional connectivity (FC). Evoked responses in S1FL were correlated positively with rsfMRI FC between bilateral S1FL (r = 0.63 to 0.69) and negatively with FC between S1FL and the anterior cingulate cortex (r = -0.50 to -0.57), suggesting that rsfMRI FC is a good index of the evoked fMRI response and anesthetized animal condition. Finally, three weekly fMRI scans were performed in 5 mice, and localized activity was reproducibly observed in S1FL, with a success rate of 70-95%. In summary, our developed fMRI protocol can be used for mapping functions of mouse models.Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9.4 T, and 4 Hz stimulation with 0.5 ms and 0.5 mA pulses induced the highest hemodynamic response. For 20-s 4-Hz unilateral forepaw stimulation, localized BOLD activity was consistently found in the contralateral primary forelimb somatosensory cortex (S1FL), while no significant change was observed in the ipsilateral S1FL. The mean magnitude was 1.44 ± 0.20% SEM (n = 9) in the contralateral S1FL and 0.69 ± 0.10% in the contralateral thalamus. The variability of evoked fMRI responses across sessions was investigated by comparing with resting state fMRI (rsfMRI) functional connectivity (FC). Evoked responses in S1FL were correlated positively with rsfMRI FC between bilateral S1FL (r = 0.63 to 0.69) and negatively with FC between S1FL and the anterior cingulate cortex (r = -0.50 to -0.57), suggesting that rsfMRI FC is a good index of the evoked fMRI response and anesthetized animal condition. Finally, three weekly fMRI scans were performed in 5 mice, and localized activity was reproducibly observed in S1FL, with a success rate of 70-95%. In summary, our developed fMRI protocol can be used for mapping functions of mouse models.
Author Lee, Joonsung
Jung, Won Beom
Kim, Seong-Gi
Shim, Hyun-Ji
Schlegel, Felix
Kim, Sangwoo
Lee, Jungryun
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29730495$$D View this record in MEDLINE/PubMed
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ISSN 1053-8119
1095-9572
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Sat Nov 29 14:30:19 EST 2025
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IsPeerReviewed true
IsScholarly true
Keywords Resting state fMRI
Electrical stimulation
BOLD
Anesthetics
Optical intrinsic signal
Isoflurane
Language English
License Copyright © 2018 Elsevier Inc. All rights reserved.
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Snippet Mouse fMRI is critically useful to investigate functions of mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often...
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SubjectTerms Anesthesia
Anesthetics
Anesthetics - administration & dosage
Animal models
Animals
Biophysics
BOLD
Cerebral blood flow
Cerebrovascular Circulation - physiology
Cortex (cingulate)
Cortex (somatosensory)
Electric Stimulation
Electrical stimulation
Forelimb - physiology
Functional magnetic resonance imaging
Functional Neuroimaging - methods
Isoflurane
Ketamine
Ketamine - administration & dosage
Laboratory animals
Magnetic Resonance Imaging - methods
Male
Mice
Mice, Inbred C57BL
Models, Animal
Neuroimaging
Optical Imaging
Optical intrinsic signal
Physiology
Resting state fMRI
Rodents
Somatosensory Cortex - diagnostic imaging
Somatosensory Cortex - physiology
Studies
Thalamus
Xylazine
Xylazine - administration & dosage
Title Mouse fMRI under ketamine and xylazine anesthesia: Robust contralateral somatosensory cortex activation in response to forepaw stimulation
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https://dx.doi.org/10.1016/j.neuroimage.2018.04.062
https://www.ncbi.nlm.nih.gov/pubmed/29730495
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Volume 177
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