Role of DNA-dependent protein kinase in recognition of radiation-induced DNA damage in human peripheral blood mononuclear cells

The DNA-dependent protein kinase (DNA-PK) complex plays a crucial role in radiation-induced DNA damage recognition. The complex includes the ku heterodimer, which comprises ku 70 and ku 80 subunits, that binds DNA termini of breaks without sequence specificity, and the catalytic subunit DNA-PKCS: Th...

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Veröffentlicht in:	International immunology Jg. 13; H. 6; S. 791
Hauptverfasser:	Frasca, D, Barattini, P, Tocchi, G, Guidi, L, Pierelli, L, Doria, G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.06.2001
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Antigens, Nuclear Cell Nucleus - enzymology Cell Nucleus - metabolism Cell Nucleus - radiation effects Cytoplasm - enzymology Cytoplasm - metabolism Cytoplasm - radiation effects Dimerization DNA - metabolism DNA - radiation effects DNA Damage DNA Helicases DNA-Activated Protein Kinase DNA-Binding Proteins - metabolism DNA-Binding Proteins - radiation effects Enzyme Activation - radiation effects Humans Ku Autoantigen Leukocytes, Mononuclear - enzymology Leukocytes, Mononuclear - radiation effects Macromolecular Substances Male Molecular Weight Nuclear Proteins - metabolism Nuclear Proteins - radiation effects Phosphorylation - radiation effects Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - physiology Protein-Serine-Threonine Kinases - radiation effects
ISSN:	0953-8178
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