Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia

In the clinical management of children with relapsed acute lymphoblastic leukemia (ALL), treatment resistance remains a major challenge. Alterations of the TP53 gene are frequently associated with resistance to chemotherapy, but their significance in relapsed childhood ALL has remained controversial...

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Bibliographic Details
Published in:	Journal of clinical oncology Vol. 29; no. 23; p. 3185
Main Authors:	Hof, Jana, Krentz, Stefanie, van Schewick, Claudia, Körner, Gabriele, Shalapour, Shabnam, Rhein, Peter, Karawajew, Leonid, Ludwig, Wolf-Dieter, Seeger, Karl, Henze, Günter, von Stackelberg, Arend, Hagemeier, Christian, Eckert, Cornelia, Kirschner-Schwabe, Renate
Format:	Journal Article
Language:	English
Published:	United States 10.08.2011
Subjects:	Child Child, Preschool Clinical Trials as Topic Disease-Free Survival Drug Resistance, Neoplasm - genetics Female Flow Cytometry Gene Deletion Humans Kaplan-Meier Estimate Male Multicenter Studies as Topic Mutation Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proportional Hazards Models Risk Factors Treatment Outcome Tumor Suppressor Protein p53 - genetics
ISSN:	1527-7755, 1527-7755
Online Access:	Get more information
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