A Change in Inflammatory Footprint Precedes Plaque Instability: A Systematic Evaluation of Cellular Aspects of the Adaptive Immune Response in Human Atherosclerosis

Experimental studies characterize adaptive immune response as a critical factor in the progression and complications of atherosclerosis. Yet, it is unclear whether these observations translate to the human situation. This study systematically evaluates cellular components of the adaptive immune resp...

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Bibliographic Details
Published in:	Journal of the American Heart Association Vol. 4; no. 4
Main Authors:	van Dijk, R. A., Duinisveld, A. J. F., Schaapherder, A. F., Mulder‐Stapel, A., Hamming, J. F., Kuiper, J., de Boer, O. J., van der Wal, A. C., Kolodgie, F. D., Virmani, R., Lindeman, J. H. N.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 26.03.2015
Subjects:	Adaptive Immunity - immunology Adaptive Immunity - physiology Adult Aorta - immunology Aorta - pathology Atherosclerosis - immunology Atherosclerosis - pathology B-Lymphocytes - pathology CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - pathology Chemokine CXCL13 - metabolism Disease Progression Female Humans Male Middle Aged Original Research Plaque, Atherosclerotic - immunology Plaque, Atherosclerotic - pathology Plasma Cells - pathology T-Lymphocyte Subsets - pathology atherosclerosis inflammation vulnerable plaque necrotic core aorta neovessel adaptive immunity
ISSN:	2047-9980, 2047-9980
Online Access:	Get full text
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