Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution

The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which—3.3 million—are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD r...

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Veröffentlicht in:Journal of the American Heart Association Jg. 9; H. 6; S. e014944
Hauptverfasser: Kim, Juyong Brian, Prunicki, Mary, Haddad, Francois, Dant, Christopher, Sampath, Vanitha, Patel, Rushali, Smith, Eric, Akdis, Cezmi, Balmes, John, Snyder, Michael P., Wu, Joseph C., Nadeau, Kari C.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England John Wiley and Sons Inc 17.03.2020
Wiley
Schlagworte:
Adolescent
Adolescent Development
Adult
Age Factors
Aged
Aged, 80 and over
Air Pollutants - adverse effects
air pollutants, environmental
Air Pollution - adverse effects
cardiovascular abnormalities
cardiovascular disease
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Child
Child Development
Child, Preschool
Comorbidity
Contemporary Review
Environmental Exposure - adverse effects
epithelial barrier
Female
Global Health
Humans
Infant
Infant, Newborn
Male
Middle Aged
Risk Assessment
Risk Factors
Time Factors
Young Adult
air pollutants, environmental
cardiovascular disease
cardiovascular abnormalities
epithelial barrier
ISSN:2047-9980, 2047-9980
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Abstract The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which—3.3 million—are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre‐existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged <15 years—1.8 billion children—breathe air that puts their health and development at risk. Here, we present growing scientific evidence, including from our own group, that chronic exposure to air pollution early in life is directly linked to development of major CVD risks, including obesity, hypertension, and metabolic disorders. In this review, we surveyed the literature for current knowledge of how pollution exposure early in life adversely impacts cardiovascular phenotypes, and lay the foundation for early intervention and other strategies that can help prevent this damage. We also discuss the need for better guidelines and additional research to validate exposure metrics and interventions that will ultimately help healthcare providers reduce the growing burden of CVD from pollution.
AbstractList The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which-3.3 million-are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre-existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged <15 years-1.8 billion children-breathe air that puts their health and development at risk. Here, we present growing scientific evidence, including from our own group, that chronic exposure to air pollution early in life is directly linked to development of major CVD risks, including obesity, hypertension, and metabolic disorders. In this review, we surveyed the literature for current knowledge of how pollution exposure early in life adversely impacts cardiovascular phenotypes, and lay the foundation for early intervention and other strategies that can help prevent this damage. We also discuss the need for better guidelines and additional research to validate exposure metrics and interventions that will ultimately help healthcare providers reduce the growing burden of CVD from pollution.
Abstract The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which—3.3 million—are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre‐existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged <15 years—1.8 billion children—breathe air that puts their health and development at risk. Here, we present growing scientific evidence, including from our own group, that chronic exposure to air pollution early in life is directly linked to development of major CVD risks, including obesity, hypertension, and metabolic disorders. In this review, we surveyed the literature for current knowledge of how pollution exposure early in life adversely impacts cardiovascular phenotypes, and lay the foundation for early intervention and other strategies that can help prevent this damage. We also discuss the need for better guidelines and additional research to validate exposure metrics and interventions that will ultimately help healthcare providers reduce the growing burden of CVD from pollution.
The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which-3.3 million-are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre-existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged <15 years-1.8 billion children-breathe air that puts their health and development at risk. Here, we present growing scientific evidence, including from our own group, that chronic exposure to air pollution early in life is directly linked to development of major CVD risks, including obesity, hypertension, and metabolic disorders. In this review, we surveyed the literature for current knowledge of how pollution exposure early in life adversely impacts cardiovascular phenotypes, and lay the foundation for early intervention and other strategies that can help prevent this damage. We also discuss the need for better guidelines and additional research to validate exposure metrics and interventions that will ultimately help healthcare providers reduce the growing burden of CVD from pollution.The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which-3.3 million-are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre-existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged <15 years-1.8 billion children-breathe air that puts their health and development at risk. Here, we present growing scientific evidence, including from our own group, that chronic exposure to air pollution early in life is directly linked to development of major CVD risks, including obesity, hypertension, and metabolic disorders. In this review, we surveyed the literature for current knowledge of how pollution exposure early in life adversely impacts cardiovascular phenotypes, and lay the foundation for early intervention and other strategies that can help prevent this damage. We also discuss the need for better guidelines and additional research to validate exposure metrics and interventions that will ultimately help healthcare providers reduce the growing burden of CVD from pollution.
Author Sampath, Vanitha
Patel, Rushali
Wu, Joseph C.
Haddad, Francois
Kim, Juyong Brian
Smith, Eric
Dant, Christopher
Akdis, Cezmi
Snyder, Michael P.
Nadeau, Kari C.
Prunicki, Mary
Balmes, John
AuthorAffiliation 2 Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
4 Swiss Institute for Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
1 Division of Cardiovascular Medicine Department of Medicine Stanford University Stanford CA
6 Department of Genetics and Center for Genomics and Personalized Medicine Stanford University Stanford CA
5 Department of Medicine University of California San Francisco and Division of Environmental Health Sciences School of Public Health University of California Berkeley CA
3 Stanford Cardiovascular Institute Stanford University Stanford CA
AuthorAffiliation_xml – name: 1 Division of Cardiovascular Medicine Department of Medicine Stanford University Stanford CA
– name: 4 Swiss Institute for Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
– name: 5 Department of Medicine University of California San Francisco and Division of Environmental Health Sciences School of Public Health University of California Berkeley CA
– name: 2 Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
– name: 6 Department of Genetics and Center for Genomics and Personalized Medicine Stanford University Stanford CA
– name: 3 Stanford Cardiovascular Institute Stanford University Stanford CA
Author_xml – sequence: 1
  givenname: Juyong Brian
  orcidid: 0000-0002-9675-2607
  surname: Kim
  fullname: Kim, Juyong Brian
  organization: Division of Cardiovascular Medicine Department of Medicine Stanford University Stanford CA, Stanford Cardiovascular Institute Stanford University Stanford CA
– sequence: 2
  givenname: Mary
  surname: Prunicki
  fullname: Prunicki, Mary
  organization: Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
– sequence: 3
  givenname: Francois
  surname: Haddad
  fullname: Haddad, Francois
  organization: Division of Cardiovascular Medicine Department of Medicine Stanford University Stanford CA, Stanford Cardiovascular Institute Stanford University Stanford CA
– sequence: 4
  givenname: Christopher
  surname: Dant
  fullname: Dant, Christopher
  organization: Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
– sequence: 5
  givenname: Vanitha
  surname: Sampath
  fullname: Sampath, Vanitha
  organization: Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
– sequence: 6
  givenname: Rushali
  surname: Patel
  fullname: Patel, Rushali
  organization: Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
– sequence: 7
  givenname: Eric
  surname: Smith
  fullname: Smith, Eric
  organization: Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
– sequence: 8
  givenname: Cezmi
  surname: Akdis
  fullname: Akdis, Cezmi
  organization: Swiss Institute for Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
– sequence: 9
  givenname: John
  surname: Balmes
  fullname: Balmes, John
  organization: Department of Medicine University of California San Francisco and Division of Environmental Health Sciences School of Public Health University of California Berkeley CA
– sequence: 10
  givenname: Michael P.
  surname: Snyder
  fullname: Snyder, Michael P.
  organization: Department of Genetics and Center for Genomics and Personalized Medicine Stanford University Stanford CA
– sequence: 11
  givenname: Joseph C.
  surname: Wu
  fullname: Wu, Joseph C.
  organization: Stanford Cardiovascular Institute Stanford University Stanford CA
– sequence: 12
  givenname: Kari C.
  surname: Nadeau
  fullname: Nadeau, Kari C.
  organization: Sean N. Parker Center for Allergy and Asthma Research Stanford University Stanford CA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32174249$$D View this record in MEDLINE/PubMed
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Keywords air pollutants, environmental
cardiovascular disease
cardiovascular abnormalities
epithelial barrier
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Snippet The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from...
The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from...
Abstract The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die...
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SubjectTerms Adolescent
Adolescent Development
Adult
Age Factors
Aged
Aged, 80 and over
Air Pollutants - adverse effects
air pollutants, environmental
Air Pollution - adverse effects
cardiovascular abnormalities
cardiovascular disease
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Child
Child Development
Child, Preschool
Comorbidity
Contemporary Review
Environmental Exposure - adverse effects
epithelial barrier
Female
Global Health
Humans
Infant
Infant, Newborn
Male
Middle Aged
Risk Assessment
Risk Factors
Time Factors
Young Adult
Title Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution
URI https://www.ncbi.nlm.nih.gov/pubmed/32174249
https://www.proquest.com/docview/2377679165
https://pubmed.ncbi.nlm.nih.gov/PMC7335506
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Volume 9
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