Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size

Background Obesity is associated with long-term health consequences including cardiovascular disease. Separating the independent effects of childhood and adulthood obesity on cardiovascular disease risk is challenging as children with obesity typically remain overweight throughout the lifecourse. Me...

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Bibliographic Details
Published in:	Journal of the American Heart Association Vol. 10; no. 17; p. e021503
Main Authors:	Power, Grace M., Tyrrell, Jessica, Frayling, Timothy M., Davey Smith, George, Richardson, Tom G.
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 07.09.2021 Wiley
Subjects:	Adult Body Size cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Child genetic epidemiology Humans lifecourse Mendelian randomization Mendelian Randomization Analysis obesity Obesity - epidemiology Obesity - genetics Original Research Risk Factors cardiovascular disease lifecourse Mendelian randomization obesity genetic epidemiology
ISSN:	2047-9980, 2047-9980
Online Access:	Get full text
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