Propofol postconditioning protects H9c2 cells from hypoxia/reoxygenation injury by inducing autophagy via the SAPK/JNK pathway

Propofol postconditioning (P-PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P-PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular medicine reports Vol. 17; no. 3; pp. 4573 - 4580
Main Authors:	Li, Hao, Zhang, Xuan, Tan, Jian, Sun, Li, Xu, Long-He, Jiang, Yu-Ge, Lou, Jing-Sheng, Shi, Xue-Yin, Mi, Wei-Dong
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01.03.2018 Spandidos Publications Spandidos Publications UK Ltd
Subjects:	Adenine - analogs & derivatives Adenine - pharmacology Animals Anthracenes - pharmacology Apoptosis Autophagy Autophagy - drug effects Biotechnology c-Jun protein Cardiomyocytes cardioprotection Cell culture Cell Hypoxia Cell survival Dosage and administration Drug interactions Health aspects Heart Heart diseases Hypoxia Immunofluorescence Ischemia ischemic postconditioning JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Lactic acid MAP kinase MAP Kinase Signaling System - drug effects Microtubule-Associated Proteins - metabolism myocardial ischemia Myocytes Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Observations Oxygen - pharmacology Phagocytosis Phosphorylation Phosphorylation - drug effects Propofol Propofol - pharmacology Protein kinases Proteins Rats Reperfusion Sequestosome-1 Protein - metabolism Stem cells Studies Transcription factors Transmission electron microscopy Western blotting United States > US
ISSN:	1791-2997, 1791-3004, 1791-3004
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!